3C protease, His, Human Protein
- Known as:
- 3C protease, histidine, Human Protein
- Catalog number:
- z03092-500
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Genscript
- Gene target:
- 3C protease His Human Protein
Related genes to: 3C protease, His, Human Protein
- Gene:
- HTRA1 NIH gene
- Name:
- HtrA serine peptidase 1
- Previous symbol:
- PRSS11
- Synonyms:
- HtrA, IGFBP5-protease, ARMD7
- Chromosome:
- 10q26.13
- Locus Type:
- gene with protein product
- Date approved:
- 1997-07-25
- Date modifiied:
- 2016-10-05
Related products to: 3C protease, His, Human Protein
Related articles to: 3C protease, His, Human Protein
- Retinitis pigmentosa (RP) is a leading cause of irreversible blindness in working-age populations and frequently cooccurs with multiple ocular disorders. As their shared genetic basis remains poorly understood, this study aimed to elucidate the shared genetic architecture underlying RP and relevant ocular comorbidities. - Source: PubMed
Publication date: 2026/06/26
Chen JiaweiYuan Xiang-LingZhang XinyueHuang QiulingZhou XiaoyuJi DanZhu WenxiangDuan Xuanchu - Articular cartilage has a specialised extracellular matrix that provides tensile strength and resistance to compression, but repair capacity is limited. Matrix remodelling during growth is essential for long-term tissue function, yet the underlying protein-level adaptations remain poorly characterised in large-animal models relevant to human joint biology. - Source: PubMed
Publication date: 2026/06/22
Giuffredi GiuliaGisbert MauroFilas Karin VancíkováFalkov JemmaDillon Eugene TMoore SarahLabberté Margot CBrama Pieter A JNowlan Niamh C - A growing number of target antigens have been identified in membranous nephropathy (MN) in recent years. Clinical correlations exist for some MN antigens, whereas others remain poorly characterized because of their rarity. High-temperature requirement A serine peptidase 1 (HTRA1) is the target antigen in approximately 1%-2% of MN cases without any established disease associations. Recent studies suggest HTRA1-MN may associate with malignancies in approximately 12% of cases, mostly solid tumors. To date, only 2 cases of HTRA1-MN have been reported in the setting of atypical hematopoietic disorders, including chronic lymphocytic lymphoma and monoclonal gammopathy of uncertain significance. Here, we present a case of HTRA1-MN with polytypic IgG deposits in a 62-year-old man with a plasma cell dyscrasia (IgA monoclonal gammopathy and 20% bone marrow involvement by a λ-restricted plasma cell neoplasm) who presented with nephrotic syndrome. A limited initial kidney biopsy suggested early MN. Daratumumab-based induction therapy resulted in a partial renal response (urinary protein-creatinine ratio of 0.7 g/g). However, proteinuria subsequently recurred (∼6.7 g/g), prompting a repeat biopsy that demonstrated HTRA1-MN with polytypic IgG staining. Proteinuria has progressively worsened (12 g/g), with persistent minimal residual plasma cell disease despite ongoing daratumumab maintenance therapy. To our knowledge, this case represents only the second reported case of HTRA1-MN occurring in the setting of monoclonal gammopathy, the first in multiple myeloma, and a rare example of a nonmonotypic MN in this context. Temporal proximity and partial response to anti-plasma cell therapy suggest a possible paraneoplastic relationship, although a causal relationship remains unproven. - Source: PubMed
Publication date: 2026/05/12
Zuckerman Jonathan ELarson SarahAbdelnour Lama - Giant cell tumor of bone (GCTB) is a locally aggressive tumor with a considerable risk of recurrence, but reliable predictive markers are limited. High-temperature requirement A serine peptidase 1 (HtrA1) has been implicated in the progression of several cancers and may also play a role in GCTB recurrence. - Source: PubMed
Publication date: 2026/06/12
Mirioglu AkifDalkir Kaan AliGokmen Mehmet YigitBagir MelihAtes Kivilcim ErenDeveci Mehmet AliGönlüşen GülfilizOzbarlas Hilmi Serdar - Migraine is a highly prevalent, heritable neurological disorder with a marked female predominance, indicating substantial hormonal contributions to disease pathophysiology. Endocrine-disrupting chemicals (EDCs) are ubiquitous environmental contaminants that interfere with hormonal signaling and have been linked to multiple diseases, yet their molecular contribution to migraine remains unclear. This study aims to identify EDC-related genes contributing to migraine risk and explore underlying mechanisms using an integrative multi-omics and causal inference framework. - Source: PubMed
Publication date: 2026/06/08
Ren YinfanXu ZiqiXu ZifeiZhang GuifangHuang HuanjieWang ChuhuaiHu Xiao-Qian