LAX1 (Human) Recombinant Protein (P01)
- Known as:
- LAX1 (Human) Recombinant Protein (P01)
- Catalog number:
- H00054900-P01-25
- Product Quantity:
- 25 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- LAX1 (Human) Recombinant Protein (P01)
Related genes to: LAX1 (Human) Recombinant Protein (P01)
- Gene:
- BZW2 NIH gene
- Name:
- basic leucine zipper and W2 domains 2
- Previous symbol:
- -
- Synonyms:
- HSPC028, MST017, MSTP017
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-05
- Date modifiied:
- 2016-10-05
- Gene:
- C2CD3 NIH gene
- Name:
- C2 calcium dependent domain containing 3
- Previous symbol:
- -
- Synonyms:
- DKFZP586P0123
- Chromosome:
- 11q13.4
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2016-06-08
- Gene:
- LAX1 NIH gene
- Name:
- lymphocyte transmembrane adaptor 1
- Previous symbol:
- -
- Synonyms:
- LAX, FLJ20340
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-04-25
- Date modifiied:
- 2014-11-19
- Gene:
- MBTD1 NIH gene
- Name:
- mbt domain containing 1
- Previous symbol:
- -
- Synonyms:
- SA49P01, FLJ20055
- Chromosome:
- 17q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-15
- Date modifiied:
- 2015-04-21
- Gene:
- TMEM63C NIH gene
- Name:
- transmembrane protein 63C
- Previous symbol:
- C14orf171
- Synonyms:
- DKFZp434P0111, CSC1, hsCSC1
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-10
- Date modifiied:
- 2017-10-17
Related products to: LAX1 (Human) Recombinant Protein (P01)
Related articles to: LAX1 (Human) Recombinant Protein (P01)
- Crohn's disease (CD) is a chronic inflammatory bowel disease marked by immune imbalance and monocyte dysfunction. IFITM3, a palmitoylation-related immune protein, may play a role in this process, but its involvement in CD remains unclear. This study aimed to explore the causal role of IFITM3 and related proteins in CD using Mendelian randomization, multi-omics analysis, and machine learning, to identify potential diagnostic markers and therapeutic targets. - Source: PubMed
Publication date: 2026/06/04
Song XinxiaYuan TangyuXing JiayinLiu Pengtao - The development of axillary meristems (AMs) is pivotal for tillering and panicle branching in rice, processes that ultimately determine grain yield. LAX PANICLE1 (LAX1) encodes a basic helix-loop-helix (bHLH) transcription factor essential for AM formation during panicle development. However, because LAX1 possesses a non-canonical basic region with fewer than five basic amino acids, it has long been presumed to lack intrinsic DNA-binding capacity, leaving its molecular mechanism of action unclear. Here, we demonstrate that LAX1 localizes to the nucleus and exhibits transcriptional activation activity. Using Systematic Evolution of Ligands by EXponential enrichment (SELEX) assays, we revealed that LAX1 possesses intrinsic DNA-binding capability in vitro. Furthermore, chromatin immunoprecipitation sequencing (ChIP-seq) analysis of young rice panicles identified direct LAX1 target genes, with binding peaks significantly enriched for a specific motif, TTTTGC(T/A/C)NNN(G/A/T), which is directly bound by the LAX1 bHLH domain. Subsequent experiments validated that LAX1 directly binds the promoters of OsPID, OsIAA7, LOG, and OsTPS8. Molecular and genetic analyses provided evidence supporting the functional role of the LAX1-OsPID module in regulating inflorescence architecture. Comparative transcriptome analysis of lax1 mutants and wild-type plants further indicated that LAX1 participates in multiple biological processes. Interestingly, we found that LAX1 and its orthologs likely regulate downstream gene expression by recognizing a common set of cis-regulatory elements across diverse cereal crops. Collectively, our findings redefine LAX1 and its orthologs as canonical bHLH transcription factors, elucidate their regulatory network in controlling panicle branching, and provide a theoretical foundation for the cross-species application of LAX1 in crop yield improvement. - Source: PubMed
Publication date: 2026/05/25
Fu DebaoXiong XiaohuWei MinghuaGao TianXu TingtingZhu JunkaiMa ShuaiguoZhu ChunmeiKong QiushengWu Changyin - BACKGROUND: Drought is a major constraint to rice (Oryza sativa L.) yield. The young spike differentiation stage is crucial for yield determination, exhibiting heightened sensitivity to soil moisture deficits. RICE CENTRORADIALIS 1 (RCN1), a TERMINAL FLOWER-like gene, is a key regulator of young spike differentiation and may mediate drought-induced delays in floral transition in rice. This study examines the effect of drought stress during the young spike differentiation stage on rice spike structure and investigates the role of RCN1 in this process. RESULTS: Drought stress markedly suppresses branch differentiation, especially secondary branches. Compared to the wild type (WT), the spike structure of rcn1 mutants was more severely compromised under drought conditions, the ABA-mediated protection of spike structure was also reduced in the rcn1 mutants. Key flowering regulators, Ehd1 and Hd1, were implicated in the regulation of young spike differentiation under drought stress, with the drought response of Ehd1 negatively modulated by RCN1. Furthermore, RCN1 influenced the expression of branch-promoting genes, including LAX1, RCN2 and RCN4 under drought. RCN1 displayed high sensitivity in rice roots, the increase rate of new roots in rcn1 mutants was lower than in WT under 10% PEG-6000 treatment. Under 15% PEG-6000 treatment, rcn1 mutants showed lower survival rate and ABA content compared to WT. CONCLUSIONS: RCN1 contributes to the maintenance of spike structure under drought stress by promoting second branch formation and affecting the drought response of some spike differentiation-related genes (Ehd1, LAX1, RCN2 and RCN4). Additionally, RCN1 enhances drought tolerance of rice by promoting abscisic acid (ABA) biosynthesis and facilitating new root germination, thereby indirectly reducing yield losses. - Source: PubMed
Publication date: 2026/04/13
Feng XinyiZhong XintongWen JiaminLiu YuWang YanZha Manrong - Pancreatic cancer remains highly lethal, largely due to late diagnosis and limited efficacy of treatments. Improving first-line treatment selection and patient monitoring requires novel, non-invasive biomarkers beyond carbohydrate antigen 19-9 (CA19-9) and imaging. This study investigates epigenetic biomarkers from liquid biopsy with prognostic and predictive potential in metastatic pancreatic ductal adenocarcinoma (PDAC; mPDAC). Genome-wide methylation profiling of cell-free DNA (cfDNA) from healthy individuals and stage IV mPDAC patients identified 13 gene-associated CpG sites with significantly altered methylation patterns. ddPCR validation confirmed consistent methylation differences in lymphocyte transmembrane adaptor 1 (), nuclear receptor subfamily 3 group C member 1 (), and between healthy and patient groups. Elevated and methylation and reduced methylation at diagnosis were associated with poor prognosis and correlated with high-risk circulating biomarker profiles, including CA19-9 levels, MAF (mutant allele fraction), cfDNA concentration, and cfDNA fragmentation. Notably, baseline methylation levels predicted response to first-line FOLFIRINOX-based treatment with an acceptable 75% sensitivity and a high specificity of 92.86%. These findings highlight the clinical significance of cfDNA methylation as a minimally invasive biomarker source, emphasizing , , and as prognostic biomarkers in mPDAC. Specifically, baseline methylation emerges as a promising predictor of treatment response, supporting personalized therapeutic strategies in mPDAC. - Source: PubMed
Publication date: 2026/03/22
Cano-Ramírez PabloToledano-Fonseca MartaCano-Osuna María TeresaHerrera-Casanova NereaCarrillo-Pecero EmilioRodríguez-Ariza AntonioAranda EnriqueGarcía-Ortiz María Victoria - Genetic transformation of elite crop varieties remains limited by genotype-specific recalcitrance and dependence on tissue culture. This review provides a comprehensive analysis of current transformation platforms and emerging strategies to overcome these bottlenecks. We examine traditional -mediated and biolistic methods, then critically assess tissue culture-free approaches including floral-based delivery, cut-dip-budding, injection, and viral vector-mediated transformation systems. A major focus is the deployment of developmental regulators-, chimeras, transcription factors, , , and -that enhance regeneration efficiency across genotypes. We detail their molecular mechanisms, from chromatin remodeling and auxin gradient establishment to wound-responsive cell reprogramming. Importantly, we address the pleiotropic developmental costs of DR misexpression and review precision control technologies, including promoter optimization and auto-excision systems, that enable transient DRs activity during regeneration while ensuring normal plant development. We propose a roadmap for integrating these advances to achieve genotype-flexible, high-throughput transformation applicable to molecular design breeding.(1). - Source: PubMed
Publication date: 2026/03/11
Guo YajieLi MengyaoLiu MengtianLiu Huiyun