Mouse IL-7 ELISA kit
- Known as:
- Mouse Interleukin-7 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- lf-ek50655
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Abfrontier
- Gene target:
- Mouse IL-7 ELISA kit
Related genes to: Mouse IL-7 ELISA kit
- Gene:
- IL7 NIH gene
- Name:
- interleukin 7
- Previous symbol:
- -
- Synonyms:
- IL-7
- Chromosome:
- 8q21.13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-10-12
- Date modifiied:
- 2016-10-11
- Gene:
- IL7R NIH gene
- Name:
- interleukin 7 receptor
- Previous symbol:
- -
- Synonyms:
- CD127, IL7RA
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2019-04-23
Related products to: Mouse IL-7 ELISA kit
Related articles to: Mouse IL-7 ELISA kit
- Extrapulmonary tuberculosis (EPTB) represents a substantial proportion of tuberculosis cases, particularly among people living with HIV. Tuberculous lymphadenitis is one of the most common forms of EPTB and represents a condition in which the lymph node functions both as an immune-organizing site and a focus of Mycobacterium tuberculosis (Mtb) infection. Although peripheral blood biomarkers are frequently used to investigate immune responses in tuberculosis, they may not accurately reflect immunological processes occurring at the site of disease. In this study, we aimed to characterize and compare systemic and local inflammatory responses in individuals with suspected lymph node tuberculosis. We conducted a case-control study including 24 individuals undergoing lymph node biopsy for pathological lymphadenopathy at the National Institute of Infectious Diseases Evandro Chagas (Fiocruz), Brazil. Eleven participants were diagnosed with tuberculous lymphadenitis (45.8%) and thirteen served as non-TB controls (54.2%). Paired plasma and lymph node interstitial fluid samples were collected, and concentrations of 29 cytokines, chemokines, and growth factors were quantified using multiplex Luminex assays. Statistical analyses included non-parametric comparisons, hierarchical clustering, Spearman correlation-based network analysis, and canonical correlation analysis to evaluate inflammatory profiles and immune network organization. Plasma inflammatory profiles did not distinguish EPTB cases from controls. In contrast, lymph node samples from EPTB participants exhibited significantly higher concentrations of IL-8, IL-3, and IL-5 and reduced IL-10 levels. Network analyses of correlations between protein concentrations revealed dense and highly interconnected inflammatory networks in plasma, centered on IL-6, IFN-α2, and IL-12p70, whereas lymph node networks were sparser and dominated by TNF-α and IL-1 family cytokines. Cross-compartment analysis identified associations between systemic mediators, particularly TNF-β and IL-7, and pro-inflammatory signals in lymph nodes. Additionally, HbA1c levels were correlated with concentrations of multiple inflammatory mediators, particularly within lymph nodes. Together, these findings indicate that tuberculous lymphadenitis is characterized by marked compartmentalization of immune responses, emphasizing the importance of tissue-level immune profiling for understanding EPTB pathogenesis. - Source: PubMed
Publication date: 2026/09/05
Vinhaes Caian Lda Silveira Samyra AlmeidaBarreto-Duarte BeatrizAndrade Bruno BSant'Anna Flávia MarinhoSchmaltz Carolina Arana StanisRidolfi Felipe MRolla Valeria CGomes-Silva Adriano - Delayed graft function (DGF) is a common early complication of kidney transplantation characterized by immune activation. The duration of DGF may significantly affect long-term graft survival, yet the immune mechanisms underlying the different DGF durations remain unclear. Using a functional definition of delayed graft function (fDGF), defined as a failure of serum creatinine to decrease by at least 10% per day for three consecutive days within the first postoperative week, patients were stratified into short-term DGF (SDGF) and long-term DGF (LDGF) groups according to recovery periods. In this exploratory study, targeted proteomic analysis indicated that proteins enriched in SDGF were primarily involved in innate immune responses and acute inflammatory processes, including neutrophil chemotaxis and migration, whereas LDGF exhibited features related to adaptive immune responses and chronic inflammation, such as T-cell differentiation and activation. IL-7 and CCL20 were identified as candidate molecules potentially associated with different DGF durations. Targeted metabolomics revealed disturbances in amino acid metabolism, particularly alanine, aspartate, and glutamate metabolism, as well as in energy metabolism, including the tricarboxylic acid (TCA) cycle, which may be involved in LDGF. These findings provide preliminary insights into immune metabolic features associated with different DGF recovery durations. - Source: PubMed
Zheng YaxinDai YongZhou FengyingLuo HaiyuWang BaoyaoLai LiushengLiao QiZou YaoshuangHuang LingyuLiu JunhongWang FengyingChen HuaizhouTang DongeYan Qiang - Neuroinflammation and systemic immune dysregulation are increasingly recognized as key contributors to secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH). However, the temporal relationship between circulating cytokine responses and innate-like lymphocyte populations, particularly mucosal-associated invariant T (MAIT) cells, remains poorly characterized. - Source: PubMed
Publication date: 2026/08/20
Merei AkosBalazs NoemiChayeen Brotzki Da CostaEngelmann PeterBerki TimeaErdő-Bonyár SzabinaSimon DianaMolnar TihamerOlah CsabaCsecsei Peter - HIV-1 reservoirs are predominantly located in CD4+ T-cells; however, not all CD4+ T-cells contribute to the reservoir in the same way. Factors such as activation, differentiation, and cell metabolism have been proposed to determine the relative susceptibility of cells to HIV-1 infection. HIV-1 reservoirs are seeded early during the acute phase of infection, but the cell composition of these reservoirs evolves in the transition to chronic infection. This suggests that there are factors during the acute phase that may alter the intrinsic susceptibility of CD4+ T-cells to HIV-1. We investigated here the influence of common cytokines known to be secreted during the acute phase and to play a role in either T cell homeostasis or HIV-1 infection on activation, differentiation, metabolic activity, and HIV-1 susceptibility of CD4+ T-cells. We show that the proinflammatory cytokines interleukin (IL)-2, IL-7, and IL-15 induce cellular activation, differentiation to effector profile, increase in metabolic capacity, and HIV-1 susceptibility. In contrast, IL-21, another cytokine from the gamma-chain (γc) family, showed opposing effects on the same parameters, including decreasing oxidative phosphorylation (OXPHOS) and HIV-1 infection. We also show that IL-10 and interferon (IFN)-α are able to at least partially revert the cellular and metabolic changes induced by IL-2 or IL-7 and reduce the cells' susceptibility to HIV-1. - Source: PubMed
Elfidha AmalDe la Torre Tarazona ErickPassaes CarolineAlcamí JoséMüller-Trutwin MichaelaSáez-Cirión Asier - Until now, human immunodeficiency virus type 1 infection monitoring is based on plasma viral load and cluster of differentiation (CD)4-positive cells from thymus (CD4+ T cells) count. However, it is increasingly accepted that this biological monitoring should be strengthened with other markers that would reinforce the management. Therefore, we addressed this task by assessing the risk associated with therapeutic failure/success linked to the dynamic of immunological parameters in people living with HIV-1 (PLHIV-1) and on antiretroviral therapy (ART) in order to identify their prognostic values. Ninety enrolled PLHIV-1 were classified according to their therapeutic status. Twenty healthy persons were also recruited as a control group. Serum cytokine levels and immune cell frequencies were determined, and the risk of therapeutic failure associated with immunological parameters was assessed. We observed low frequencies of CD4+ T, natural killer (NK), natural killer T (NKT) cells, classical monocytes, nonclassical monocytes, granulocytes, and high frequency of CD8+ T cells in all PLHIV-1 groups in treatment failure under dolutegravir (DTG) and efavirenz (EFV) regimens compared to control participants. Moreover, interferon-gamma (IFN-γ) levels decreased in PLHIV-1 with therapeutic success under the DTG regimen, while interleukin-4 (IL-4) increased in treatment success under the EFV regimen. Proinflammatory tumor necrosis factor-alpha (TNF-α), IL-6, and IL-7 significantly increased in therapeutic failure groups under both regimens. IL-5 concentrations increased in all PLHIV-1, while IL-13 levels did not change. Logistic regression analysis revealed a positive correlation between the risk of treatment failure and proinflammatory cytokines IFN-γ, TNF-α, IL-6, IL-7, eosinophils, and CD8+ T cells in PLHIV-1 under EFV and DTG regimes. In contrast, the risk of therapeutic failure decreased with increasing numbers of CD4+ T cells, neutrophils, and the anti-inflammatory IL-4 in PLHIV-1 treated with the same antiretroviral molecules. Collectively, these results indicated that pro- and anti-inflammatory cytokines and immune cells could serve as prognostic factors for monitoring HIV-1 disease progression and response to ART. However, further studies with a larger sample size would be needed to confirm our data. - Source: PubMed
Publication date: 2026/08/30
Assogba Yaou PierrotNouatin Odilon PaterneTchiakpe EdmondAdechina Adefounke PrudenciaFachinan Rufine AbossèdéAdegnika Roukoyath MoyoriolaAdjou Euloge SènanDiop-Ndiaye HalimatouBankole Honoré SourouYessoufou Akadiri