Human SOD3 ELISA kit
- Known as:
- Human SOD3 Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- lf-ek0107
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Abfrontier
- Gene target:
- Human SOD3 ELISA kit
Related genes to: Human SOD3 ELISA kit
- Gene:
- SOD3 NIH gene
- Name:
- superoxide dismutase 3
- Previous symbol:
- -
- Synonyms:
- EC-SOD
- Chromosome:
- 4p15.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-05-08
- Date modifiied:
- 2017-01-11
Related products to: Human SOD3 ELISA kit
Related articles to: Human SOD3 ELISA kit
- Ruminants experience major metabolic stress during the periparturient period, leading to negative energy balance (NEB), oxidative stress, and inflammation. While NEB is well studied in dairy cows, molecular responses to feed restriction in locally adapted fat-tailed sheep breeds remain unclear. This study aimed to study the effect of phased feed restriction and parturition on hepatic genes related to antioxidant defense, NADPH regeneration, and inflammation in Lori Bakhtiari and Turki Qashqai ewes. Twenty ewes were used in this study. The control group (Ctrl; n=10) received pre- and postpartum diets to meet 100% of the energy requirements. The Feed Restricted group (FR; n=10) received a diet to simulate a sudden energy deficit prepartum and postpartum. Liver biopsies were collected on week -3 and 3 relative to parturition. Pro-inflammatory cytokines (IL-6, IL-8, TNFα) were unaffected by FR or parturition. The hepatic mRNA expression of GCLM remained constant in the FR group but decreased in the Ctrl group postpartum. In addition, GCLM mRNA abundance was lower in the FR group compared to the Ctrl group prepartum, but higher postpartum. The hepatic mRNA expression of SRXN1 increased postpartum in the FR group but remained constant in Ctrl. In addition, SRXN1 showed higher abundance in the FR group than in the Ctrl group both prepartum and postpartum. Both hepatic mRNA expression of GPX3 and GPX4 were constant in the FR group but increased in the Ctrl group postpartum. Thus, no differences in GPX3 and GPX4 were detected between groups prepartum but were lower in the FR group compared to the Ctrl group postpartum. In addition, FR downregulated the hepatic mRNA expression of GCLC, G6PD, 6PGD, CAT, SOD1, and SOD3, while increasing GR1. Parturition decreased the hepatic mRNA expression GCLC, G6PD, 6PGD, and TXNRD1, and increased Hb, SOD1, and SOD3 mRNA abundance. Feed restriction reduced key hepatic antioxidant and NADPH-regenerating genes, while parturition further intensified oxidative processes. Despite these sudden changes in dietary energy prepartum and postpartum, inflammatory cytokines remained constant, indicating that fat-tailed ewes prioritize redox adaptation over inflammation under nutritional stress and parturition-related metabolic demands. - Source: PubMed
Publication date: 2026/05/19
Pazir RahimZarrin MousaAhmadpour AmirHernández-Castellano Lorenzo E - This study aimed to explore the anti-aging effects and mechanisms of Dendrobium nobile Lindl. Alkaloids (DNLA) on Caenorhabditis elegans (C. elegans). - Source: PubMed
Publication date: 2026/05/19
Liu JingZhang JingxinCui DiXu YunyanLiu Bo - Lumpy skin disease (LSD) is a transboundary animal disease that has serious implications for livestock trade and food security. This study aimed to investigate the molecular and immunological determinants of LSD in vaccinated cattle that developed clinical disease (vaccine breakthrough cases), and to identify potential biomarkers to support disease surveillance and control strategies. - Source: PubMed
Publication date: 2026/04/23
Alqhtani Haifa AliMarzok MohamedElsayed Ahmed AGhonaim Ahmed HAlmubarak Adel IElJalii Isam MohamedBabiker HusseinAlameen Ahmed OmerShoukry MoustafaAbdel-Raheem Sherief MEl-Sabagh Ibrahim MHamed Mohamed FSafhi Fatmah AhmedAlzahrani Elham MohammedAteya AhmedKaram Reham - Drought-induced senescence is a major cause of maize yield loss. While biostimulant priming improves stress tolerance, its molecular basis is unclear. Here we demonstrate that priming maize with the plant-derived biostimulant AgriPrime Stimulus (APS) delays drought-induced leaf senescence at reproductive-stage, resulting in improved cob weight and yield. Integrated physiological, transcriptomic, metabolomic, and phytohormone analyses revealed that APS priming preserves source leaf functionality by maintaining key metabolic processes. APS-primed drought-stressed leaves showed enrichment of photosynthesis-related genes and elevated levels of tricarboxylic acid cycle intermediates, indicating maintained carbon metabolism. APS priming also strengthened cell wall through the induction of genes involved in cellulose, hemicellulose, pectin, cutin, and wax biosynthesis, with increased structural metabolites such as xylose, mannose, and galactonic acid. Delayed senescence was further supported by enhanced redox homeostasis, with upregulation of antioxidant-related genes including superoxide dismutase (SOD3), peroxidases (PRXs), glutathione S-transferases (GSTs), and ascorbate-associated genes (BX13), together with increased levels of protective metabolites such as proline, trehalose, and myo-inositol. In parallel, APS priming suppressed proteolysis and senescence-associated genes (NYC1, NYE1, SAG39, NAC042). Integration of phytohormone and transcriptomic data further revealed maintained growth-promoting hormones alongside reduced abscisic acid and ethylene biosynthesis. Consistent with this reduced catabolic state, APS-primed leaves accumulated amino acids linked to growth, while unprimed drought-stressed leaves accumulated amino acids related to protein degradation. Collectively, these findings show that APS priming preserves source-sink relationships during drought by maintaining leaf longevity, and strengthening sink support, which improves cob weight under water deficit. - Source: PubMed
Publication date: 2026/05/04
Kanojia AakanshaSujeeth NeerakkalGupta SaurabhAlseekh SalehPetrov VeselinGechev Tsanko S - Aging is a complex biological process characterized by progressive functional decline across tissues and increased susceptibility to age-related diseases, with oxidative stress being a key contributing factor. Glycine-Histidine-Lysine (GHK), a naturally occurring tripeptide present in human plasma and urine, possesses potent antioxidant properties; however, its broader anti-aging potential remains inadequately explored. In this study, we employed the model organism Caenorhabditis elegans to systematically investigate the anti-aging effects of GHK-Cu (GHK complexed with copper) and elucidate its underlying molecular mechanisms. Our results demonstrated that GHK-Cu significantly extended lifespan of C. elegans and ameliorated mutiple aging-related phenotypes, including enhanced resistance to oxidative and thermal stress, improved motility, pharyngeal pumping, defecation rhythm, and reduced lipofuscin/lipid accumulation. Mechanistically, GHK-Cu preserved mitochondrial function by increasing mitochondrial membrane potential, alleviating age-related mitochondrial network fragmentation, shifting mitochondrial dynamics toward fusion via regulating drp-1 and fzo-1 expression, and promoting ATP biosynthesis. Meanwhile, GHK-Cu activating DAF-16 and SKN-1 pathway, and upregulating sod-3, gst-4, gcs-1, lys-7 and lys-8. This study provides the first mechanistic evidence that GHK-Cu delays aging through coordinated regulation of mitochondrial function and activation of both DAF-16 and SKN-1 pathways. Our findings identify novel molecular targets for developing anti-aging interventions and underscore the potential of GHK-Cu's as a multifaceted geroprotective compound. - Source: PubMed
Publication date: 2026/05/05
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