anti-SLC12A2 / NKCC1
- Known as:
- (anti-) to-SLC12A2 / NKCC1
- Catalog number:
- lf-pa43886
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Abfrontier
- Gene target:
- anti-SLC12A2 / NKCC1
Related genes to: anti-SLC12A2 / NKCC1
- Gene:
- SLC12A2 NIH gene
- Name:
- solute carrier family 12 member 2
- Previous symbol:
- -
- Synonyms:
- NKCC1, BSC, BSC2, PPP1R141
- Chromosome:
- 5q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-02-16
- Date modifiied:
- 2016-02-17
Related products to: anti-SLC12A2 / NKCC1
Alkaline Phosphatase Conjugated Affinity Purified anti-Swine IgG (H&L) [Goat] Secondary_Antibodies(endo,anti)_((rac,anti)-4-Deschloro-sertraline CAS: Formula: C17H18ClN(Tyr1)-Adipokinetic Hormone I, Rabbit anti-Locusta migratoria(Tyr1)-Adipokinetic Hormone I, Rabbit anti-Locusta migratoria, IF Kit(Tyr1)-Adipokinetic Hormone I, Rabbit anti-Locusta migratoria; IH(Tyr1)-Adipokinetic Hormone I, Rabbit anti-Locusta migratoria; RIA1 JAR WITH WIDE BOTTOM PLATE (ANTI-TILT)1 JAR WITH WIDE BOTTOM PLATE (ANTI-TILT)1-step Polymer HISTO-STAT; HRP anti Hamster (Secondary Reagent Component) for staining Hamster antibodies, 250 plus slides1-step Polymer HISTO-STAT; HRP anti Chicken (Secondary Reagent Component) for staining Chicken antibodies, 250 plus slides1-step Polymer HISTO-STAT; HRP anti Goat (Secondary Reagent Component) for staining Goat antibodies, 250 plus slides1-step Polymer HISTO-STAT; HRP anti Mouse Adsorbed (Secondary Reagent Component) for staining Rat antibody- on- Mouse tissues, 250 plus slides1-step Polymer HISTO-STAT; HRP anti Mouse Secondary Reagent Component) for staining Mouse and Rat antibodies, 250 plus slides1-step Polymer HISTO-STAT; HRP anti Rat (SecondaryReagent Component) for staining Rat antibodies, 250 plus slides Related articles to: anti-SLC12A2 / NKCC1
- Prenatal ethanol (alcohol) exposure (PreEE) results in abnormal tangential migration of medial ganglionic eminence (MGE)-derived GABAergic interneurons (GINs) in the embryonic mouse medial prefrontal cortex (mPFC); later in life, this is associated with impaired behavioral flexibility commonly seen in fetal alcohol spectrum disorders (FASD). The PreEE-induced abnormal tangential migration involves, in part, ethanol potentiating GABA receptor-mediated depolarization, the latter due to elevated intracellular chloride sustained primarily by the Na-K-Cl cotransporter NKCC1 in embryonic GINs. We previously reported that coincident administration of the NKCC1 antagonist bumetanide with PreEE prevents the PreEE-induced aberrant migration of GINs in the mPFC. However, such simultaneous dispensing rarely occurs in real life. In this light, the present study assessed whether bumetanide administered after PreEE mitigates the PreEE-induced aberrant tangential migration. - Source: PubMed
Koc BetulSkorput Alexander G JYeh Pamela W LYeh Hermes H - The mammalian tracheal epithelium is composed of different cell types distributed along the proximal-distal axis. Nevertheless, variations in expression and function of ion channels and transporters participating in fluid absorption and secretion have never been studied separately in proximal and distal mouse trachea. This work aims to characterize basal and stimulated absorption and secretion of fluid obtained from proximal and distal trachea from the same animal. - Source: PubMed
Apablaza TábataVillanueva SandraOlave-Ruiz AraceliGuequen AnitaCatalán Marcelo AFlores Carlos A - Abdominal pain is a hallmark symptom of both inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) and substantially impairs patients' quality of life. Relaxation response-based mind-body intervention (RR-MBI) has been reported to improve disease-specific outcomes and pain catastrophizing in both disorders, accompanied by whole-blood transcriptomic changes. However, the transcriptional features potentially relevant to abdominal pain before and after RR-MBI in IBS and IBD remain insufficiently explored. In this context, this study aimed to analyze these transcriptional changes and prioritize putative abdominal pain-relevant candidate genes from exploratory differentially expressed gene (DEG) sets. - Source: PubMed
Publication date: 2026/06/10
Lin ZhongyuanMo GuohuiWang YiminLin ShiqingGuo Qianqian - Both hypertensive and breast diseases impose a significant societal burden. However, the correlation between antihypertensive drug use and breast cancer remains controversial. We aimed to determine their potential correlations and explore their possible mechanisms. We performed summary data-based Mendelian Randomization (SMR) analysis of expression quantitative trait loci (eQTL) data from the blood of patients with breast diseases. We then performed drug-targeting Mendelian Randomization (MR) analysis using blood pressure-related single nucleotide polymorphism (SNPs) as instrumental variables (IVs). False discovery rate (FDR) correction was performed for reliable results, and colocalization analysis was performed to clarify shared gene variants. Mediation MR methods were used to investigate the mechanistic pathways involved in this association. Combined with the results of SMR analysis and drug-targeting MR analysis, loop diuretics aggravated overall breast cancer (OR_SMR = 0.842, 95% CI_SMR: 0.778-0.911, P_SMR_FDR = 0.008) and ER + breast cancer (OR_SMR = 0.854, 95% CI_SMR: 0.778-0.937, P_SMR_FDR = 0.008) within SLC12A2 gene loci. Colocalization analysis showed that SLC12A2-targeted drugs share a common variant site with breast cancer. Mediation analyses suggested that the pathway related to intestinal ischemia mediated 73.711% of the total effect on over breast cancer risk in the SLC12A2 gene loci. Antihypertensive drugs increase the overall risk of breast cancer and ER + breast cancer within the SLC12A2 gene. And overall breast cancer risk which may result from intestinal ischemia. Given the long-term safety of antihypertensive drugs, significance should be attached to the prevention and early detection of breast cancer in patients taking loop diuretics. - Source: PubMed
Li JiaxuanMa YiqunZhang Kaili - Gamma-aminobutyric acid (GABA), acting through its receptors, is the principal inhibitory neurotransmitter in the brain. It plays a vital role in maintaining neuronal chloride balance by interacting with chloride co-transporters, mainly NKCC1 and KCC2. In addition to the neurons, GABA receptors and chloride co-transporters are found to be expressed by the immune cells also. This present work aimed to study the gene expression patterns of GABA receptors and chloride co-transporters (NKCC1 and KCC2) in the autism-affected children of West Bengal using peripheral blood as model. - Source: PubMed
Publication date: 2026/06/04
Adak PallabiChakraborty Samidh SankarBandyopadhyay Apurba KumarSinha SwagataBanerjee Nilanjana