Mouse pre-microRNA Expression Construct mir-30a
- Known as:
- Mouse pre-microRNA Expression Construct mir-30a
- Catalog number:
- mmir-30a-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-30a
Related genes to: Mouse pre-microRNA Expression Construct mir-30a
- Gene:
- MIR30A NIH gene
- Name:
- microRNA 30a
- Previous symbol:
- MIRN30A
- Synonyms:
- hsa-mir-30a
- Chromosome:
- 6q13
- Locus Type:
- RNA, micro
- Date approved:
- 2004-04-23
- Date modifiied:
- 2019-01-24
Related products to: Mouse pre-microRNA Expression Construct mir-30a
Related articles to: Mouse pre-microRNA Expression Construct mir-30a
- Following the publication of the above paper, it was drawn to the Editor's attention by an interested reader that a pair of unsuitable antibodies may have been used as a part of the western blot analysis shown in Fig. 1E on p. 1314. First, the antibody with the catalogue number ab51243 (purchased from Abcam), is not specific for p16‑INK4a (the senescence‑associated protein studied in this paper), but a totally different protein with a similar name, p16‑ARC. A concern was also raised regarding the anti‑β‑galactosidase antibody (cat. no. ab9361; Abcam) that was employed, which is specific for the bacterial protein and is only distantly related to human β‑galactosidase according to its sequence (neither is this antibody the closest homologue to bacterial β‑galactosidase in the human proteome). The authors have been contacted by the Editorial Office to offer an explanation for the selection of these apparently unsuitable antibodies for the western blot analysis, and we are awaiting their response. Owing to the fact that the Editorial Office has been made aware of a potential problem surrounding the design of these experiments in this study, we are issuing an Expression of Concern to notify readers of this issue while the Editorial Office continues to investigate this matter further. [International Journal of Molecular Medicine 43: 1311‑1320, 2019; DOI: 10.3892/ijmm.2019.4074]. - Source: PubMed
Publication date: 2026/09/11
Tan PanWang HaiqinZhan JunkunMa XinyuCui XingjunWang YanjiaoWang YiZhong JiayuLiu Youshuo - Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro-RNA (miRNA)-mRNA regulatory networks underlying region-specific molecular mechanisms in white matter and gray matter lesions in progressive MS. - Source: PubMed
Publication date: 2026/08/31
Sapra AdyaRai Nagendra KNiepokny Timothy DCourtney HaleyTripathi AjaiDutta Ranjan - Dysregulated sphingolipid metabolism plays a key role in atopic dermatitis (AD), yet therapeutic options targeting this pathway remain limited. The traditional formula Peitu Qingxin (PTQX) shows clinical efficacy, but its molecular mechanism is largely undefined. - Source: PubMed
Publication date: 2026/07/22
Wu WenfengZhang ZexinZhou BoqianLiu JunfengJia JinjingZhang YuLi XiongSun NanLi YanhuiLin YingChen DacanMo XiumeiLi HongyiYan Fenggen - Our study aims to examine possible Parkinson Disease (PD)-related circulating microRNAs (miRNA) and their potential roles and use cases in screening, diagnosis, and the disease progress in Turkish population. For this purpose, we selected 7 promising candidates namely miR-16-1, miR-24-3p, miR-30a, miR-30e, miR-34a, miR-34b, miR-331 from multiple studies and bioinformatic web tools. For our study, 51 PD patients with no other severe disease except for hypertension and 20 healthy matching controls were included. Serum samples were collected from venous blood and stored properly. RNA extraction, reverse transcription and real-time polymerase chain reaction (qPCR) for each pre-determined miRNA were applied to all samples with a strong normalization method to determine expression levels. Additionally, validated miR-24-3p target genes were intersected against publicly available CSF proteomics (PXD011216), PBMC transcriptomics (GSE22491), and serum metabolomics (MTBLS10958) datasets. miR-24-3p expression was also examined in two independent miRNA datasets (GSE269775; GSE16658). Statistical analyses were done using SPSS and Qiagen GeneGlobe webtools. Between PD and the control group, miR-24-3p serum levels were found increased 1.7 times (p = 0.0001). Among patients, miR-331 serum levels changed significantly with UPDRS scores (p = 0.027). Multi-omics analysis identified 21 differentially abundant miR-24-3p target proteins in PD CSF (81% downregulated), three cross-platform concordant targets, and five metabolically linked pathways. miR-24-3p levels may differ in different biological compartments in PD. In serum, miR-24-3p may provide significant value as a diagnostic biomarker with 80.4% sensitivity and 85% specificity. miR-331 might be a candidate for predicting the severity of the disease. - Source: PubMed
Publication date: 2026/07/14
Kaya Ibrahim AlperDemircan BernaOzdilek Fatma BetulBaran MustafaDogan Emine SenaKoc Ada SaniyeBursa Muhammet CaglarKaya Bursa Aslı PelinÖztekin ZeynepGurvit Ibrahim Hakan - Brain-derived neurotrophic factor (BDNF) plays a crucial role in the initial formation of the central auditory system and the sensory epithelium within the inner ear. Mounting evidence indicates that BDNF administration promotes microRNA (miRNA) production in neurons, despite the typical suppressive effect of miRNAs on BDNF expression. Therefore, miRNAs regulating BDNF expression may impact the auditory system and serve as potential gene polymorphisms affecting human hearing ability. This study aimed to investigate the contribution of miRNA polymorphisms affecting BDNF to tinnitus pathophysiology. - Source: PubMed
Publication date: 2026/02/25
Dogan GulBoyacioglu OlcayDogan MuratSahin MustafaBoyacioglu Seda Orenay