Mouse pre-microRNA Expression Construct mir-302b
- Known as:
- Mouse pre-microRNA Expression Construct mir-302b
- Catalog number:
- mmir-302b-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-302b
Related genes to: Mouse pre-microRNA Expression Construct mir-302b
- Gene:
- MIR302B NIH gene
- Name:
- microRNA 302b
- Previous symbol:
- MIRN302B
- Synonyms:
- hsa-mir-302b
- Chromosome:
- 4q25
- Locus Type:
- RNA, micro
- Date approved:
- 2004-07-22
- Date modifiied:
- 2019-01-30
Related products to: Mouse pre-microRNA Expression Construct mir-302b
Related articles to: Mouse pre-microRNA Expression Construct mir-302b
- The study by Bi . (2025) presents "Senoreverse", an innovative strategy that utilizes exosomal miR-302b to restore the proliferative capacity of senescent cells (SnCs), thus extending lifespan and enhancing cognitive and physical function in aging mice without the risk of tumorigenicity. - Source: PubMed
Publication date: 2025/04/02
Borrás Consuelo - Our labs have demonstrated exercise is protective in animal models of retinal degeneration (RD). Inflammation drives RD progression, and is regulated by the recruitment and reactivity of glia cells as well as through small non-coding RNAs, microRNAs (miRNAs). Here, we explore the effects of treadmill exercise on the recruitment and reactivity of retinal inflammatory cells within the neural retina and miRNA expression in a light-induced retinal degeneration model (LIRD) that exhibits phenotypes found in patients with RD. - Source: PubMed
Publication date: 2025/07/21
Haupt HaydenChen Vivian SPalumaa TeeleAnderson Teresa ERodriguez Gabriela SanchezChu-Tan JoshuaNatoli RiccardoFeola Andrew JNickerson John MPardue Machelle TBoatright Jeffrey HBales Katie L - Cellular senescence, a hallmark of aging, involves a stable exit from the cell cycle. Senescent cells (SnCs) are closely associated with aging and aging-related disorders, making them potential targets for anti-aging interventions. In this study, we demonstrated that human embryonic stem cell-derived exosomes (hESC-Exos) reversed senescence by restoring the proliferative capacity of SnCs in vitro. In aging mice, hESC-Exos treatment remodeled the proliferative landscape of SnCs, leading to rejuvenation, as evidenced by extended lifespan, improved physical performance, and reduced aging markers. Ago2 Clip-seq analysis identified miR-302b enriched in hESC-Exos that specifically targeted the cell cycle inhibitors Cdkn1a and Ccng2. Furthermore, miR-302b treatment reversed the proliferative arrest of SnCs in vivo, resulting in rejuvenation without safety concerns over a 24-month observation period. These findings demonstrate that exosomal miR-302b has the potential to reverse cellular senescence, offering a promising approach to mitigate senescence-related pathologies and aging. - Source: PubMed
Publication date: 2025/01/15
Bi YoukunQiao XinlongCai ZhaokuiZhao HailianYe RongLiu QunGao LinLiu YingqiLiang BoLiu YixuanZhang YaningYang ZhiguangWu YanyunWang HuiwenJia WeiZeng ChangqingJia CeWu HongjinXue YuanchaoJi Guangju - Oral squamous cell carcinoma (OSCC) is among the most malignant cancers in the world and has a high mortality rate. MicroRNAs (miRNAs) have progressively gained attention due to their roles in the pathogenesis and maintenance of various kinds of cancers, including OSCC. In this research, we carried out a scoping review to analyze the role of miRNA and therapeutic response in OSCC and focus on target axes associated with miRNA that inhibit metastasis and cell proliferation in OSCC. - Source: PubMed
Publication date: 2024/08/11
Malekjafarian Seyed MostafaMohtasham NooshinMirhashemi MajidSadeghi MasoumehArab FatemehMohajertehran Farnaz - Cardiac fibrosis is one of the top killers among fibrotic diseases and continues to be a global unaddressed health problem. The lack of effective treatment combined with the considerable socioeconomic burden highlights the urgent need for innovative therapeutic options. Here, we evaluated the anti-fibrotic properties of extracellular vesicles (EVs) derived from human induced pluripotent stem cells (hiPSCs) that were cultured under various oxygen concentrations. - Source: PubMed
Publication date: 2023/10/31
Paw MilenaKusiak Agnieszka ANit KingaLitewka Jacek JPiejko MarcinWnuk DawidSarna MichałFic KingaStopa Kinga BHammad RubaBarczyk-Woznicka OlgaCathomen ToniZuba-Surma EwaMadeja ZbigniewFerdek Paweł EBobis-Wozowicz Sylwia