Mouse pre-microRNA Expression Construct mir-301b
- Known as:
- Mouse pre-microRNA Expression Construct mir-301b
- Catalog number:
- mmir-301b-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-301b
Related genes to: Mouse pre-microRNA Expression Construct mir-301b
- Gene:
- MIR301B NIH gene
- Name:
- microRNA 301b
- Previous symbol:
- MIRN301B
- Synonyms:
- hsa-mir-301b
- Chromosome:
- 22q11.21
- Locus Type:
- RNA, micro
- Date approved:
- 2007-10-24
- Date modifiied:
- 2019-01-30
Related products to: Mouse pre-microRNA Expression Construct mir-301b
Related articles to: Mouse pre-microRNA Expression Construct mir-301b
- Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of advanced non-small cell lung cancer (NSCLC). However, the limited predictive value of PD-L1 expression as a biomarker underscores the urgent need for more reliable predictors of ICI response. Interferon regulatory factor 1 (IRF1) is a transcription factor that lies downstream of interferon-γ signaling and directly regulates (PD-L1) transcription. Here, we performed a comprehensive bioinformatic analysis to identify microRNAs (miRNAs) that may be associated with expression in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). Using data from The Cancer Genome Atlas (TCGA), we identified 20 miRNAs whose expression levels consistently and negatively correlated with IRF1 mRNA levels in both LUAD and LUSC. Among these, only hsa-miR-301b possesses conserved binding sites in the 3'UTR of IRF1 mRNA, suggesting direct post-transcriptional repression. For the remaining 19 miRNAs, we hypothesized an indirect mechanism of action. Further analysis revealed that hsa-miR-183 and hsa-miR-141 may target the transcription factor genes and , respectively, both of which positively correlate with expression and are themselves associated with improved survival in ICI-treated patients. This study delineates a multi-layer miRNA regulatory network associated with expression in NSCLC and identifies hsa-miR-301b, hsa-miR-183 and hsa-miR-141 as candidate upstream regulators of . Direct survival analysis for these miRNAs in ICI-treated cohorts was not feasible due to the lack of publicly available miRNA-seq data with treatment annotations; therefore, their clinical predictive value remains hypothetical, and experimental validation is required to assess their potential as predictors of ICI response. - Source: PubMed
Publication date: 2026/06/08
Karaseva Dariya VPerevalova Alina MKalinina Tatiana SKononchuk Vladislav VKozlov Vadim VGulyaeva Lyudmila FPustylnyak Vladimir O - Macrophage efferocytosis, the clearance of apoptotic cells, is essential for tissue homeostasis and preventing inflammation. Impaired efferocytosis contributes to chronic inflammatory conditions, including obesity. However, its key regulators remain unclear. MicroRNA-130b (miR-130b) is increased in adipose tissue macrophages of individuals with obesity. Here, we found that miR-130b was enriched in bone marrow of mice, and its expression in bone marrow-derived macrophages was suppressed by IL-4 and by apoptotic cell uptake. Deletion of the miR-130b and its cluster member miR-301b enhanced macrophage efferocytosis and apoptotic cell clearance , accompanied by increased mitochondrial respiration and anti-inflammatory polarization. In high fat diet-fed mice, global deletion of miR-130b/301b reduced inflammatory gene expression in adipose tissues. Mechanistically, miR-130b suppressed PPARγ and PGC-1α, regulators of mitochondrial metabolism and inflammation, and miR-130b/301b deletion increased CX3CR1, a receptor for apoptotic cell "find me" signals. Together, miR-130b/301b deletion promotes macrophage efferocytosis and resolves adipose tissue inflammation. - Source: PubMed
Publication date: 2026/03/10
Yang LeiAbuduyimiti TuerdiguliXi YiboCoppola GianfilippoLiu ChenJiang Shaoning - Type 2 inflammation and epithelial-mesenchymal transition (EMT) are critical components in the pathogenesis of eosinophilic chronic rhinosinusitis (ECRS), yet their upstream regulatory mechanisms remain poorly understood. This study aimed to explore the regulatory role of miR-301b-3p in these mechanisms and evaluate its therapeutic potential. - Source: PubMed
Publication date: 2025/07/30
Shu FuWang YapingJiang YihengLi LinglongMu ZengyiShi LeiGong XiaobaoZhang BaoshunZhang FengMao Dehong - microRNAs (miRNAs) are crucial regulators of various biological processes and molecular functions. Aberrant miRNA expression has been linked in many studies to neoplastic transformation. Among these miRNAs, dysregulation of miR-301b-5p was associated with different types of cancer including breast cancer. Although many research works have investigated the function of miR-301b in carcinogenesis, few have examined its expression, biological, and clinical implications in breast cancer. - Source: PubMed
Publication date: 2024/08/12
Taha MohamedYousef EinasBadr Ahmed NawarSalama Rasha AMaurice Nadine - Parkinson's disease (PD) is a rapidly growing neurological disorder characterized by diverse movement symptoms. However, the underlying causes have not been clearly identified, and accurate diagnosis is challenging. This study aimed to identify potential biomarkers suitable for PD diagnosis and present an integrative perspective on the disease. - Source: PubMed
Publication date: 2024/05/09
Chun Ka-YoonKim Seung-Nam