Mouse pre-microRNA Expression Construct mir-29c
- Known as:
- Mouse pre-microRNA Expression Construct mir-29c
- Catalog number:
- mmir-29c-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-29c
Related genes to: Mouse pre-microRNA Expression Construct mir-29c
- Gene:
- MIR29C NIH gene
- Name:
- microRNA 29c
- Previous symbol:
- MIRN29C
- Synonyms:
- hsa-mir-29c
- Chromosome:
- 1q32.2
- Locus Type:
- RNA, micro
- Date approved:
- 2004-04-23
- Date modifiied:
- 2019-01-24
Related products to: Mouse pre-microRNA Expression Construct mir-29c
Related articles to: Mouse pre-microRNA Expression Construct mir-29c
- Conventional therapies for oral submucous fibrosis (OSF) are largely conservative and have limited ability to modify the underlying fibrotic process or prevent disease progression. This limitation highlights the need for targeted molecular therapies. MicroRNAs (miRNAs) have recently emerged as promising anti-fibrotic regulators capable of modulating key profibrotic signalling pathways. - Source: PubMed
Publication date: 2026/08/27
Shetty Smitha SammithSharma MohitRadhakrishnan Raghu - Increasing life expectancy has been accompanied by a higher prevalence of age-associated conditions, underscoring the need to better understand biological mechanisms of aging and to identify accessible biomarkers. Extracellular vesicles (EVs) are lipid-bilayer vesicles that mediate intercellular communication by transporting proteins, lipids, and regulatory RNAs, including microRNAs (miRNAs). Here, we investigated whether the abundance, morphology, and molecular cargo of plasma-derived EVs differ between young and senior dogs. Blood samples were obtained from 24 clinically healthy dogs in Gama (Federal District, Brazil), and plasma EVs were isolated by sequential centrifugation, filtration through a 0.22 μm filter, and ultracentrifugation. EVs concentration and size distribution were assessed by nanoparticle tracking analysis (NTA), morphology by transmission electron microscopy (TEM), and cargo by quantification of total protein and sterols using commercial assays. In addition, we quantified miR-19b, miR-29c, miR-7, miR-155, and miR-21 by Real Time Quantitative Polymerase Chain Reaction (RT-qPCR). Senior dogs exhibited a lower plasma EV yield and greater size heterogeneity, with a higher proportion of larger EVs. Total protein and sterol content per starting plasma volume were reduced in the senior group; however, sterol normalized per EV was increased, consistent with compositional remodeling of circulating vesicles with age. Finally, EV-associated miRNA levels were reduced in senior dogs, particularly miR-19b and miR-29c. Collectively, these findings indicate that canine aging is associated with marked changes in plasma EV abundance, morphology, and cargo, indicating that EVs could represent a promising tool for investigating age-related disorders in dogs. - Source: PubMed
Publication date: 2026/06/19
Marina Clara LunaGreuel Alexandra MazerLas-Casas Lucas de OLopes-Gomes EvillyRomero Ferrari Sabrina Simplício de AraújoRodrigues Marcio LourençoDos Reis Flavia C GBocca Anamélia LorenzettiTitze-de-Almeida Simoneide SouzaResende Fernando Francisco Borgesde Sant'Ana Fabiano José FerreiraTitze-de-Almeida Ricardo - Piperine, the principal alkaloid of Piper nigrum, has gained attention as a multifunctional dietary compound with broad effects on epigenetic and transcriptional regulation in cancer and chronic diseases. Evidence shows that piperine modulates DNA methylation (↓ DNMT3B), histone acetylation (↓ HDAC activity), and microRNA networks (↑ miR-29c, ↓ miR-383), thereby reshaping key oncogenic and tumor-suppressive pathways. Beyond canonical epigenetic control, it can also stabilize G-quadruplex structures in promoters such as c-MYC, adding an architecture-based mechanism of transcriptional repression. Its dual redox behavior-antioxidant at low doses and pro-oxidant at higher doses-confers context-dependent selectivity, enabling oxidative stress-mediated apoptosis in tumor cells. Compared with other nutriepigenetic agents (curcumin, resveratrol, EGCG), piperine stands out for its multi-target profile and preliminary evidence of activity against cancer stem cell-like phenotypes. Nonetheless, limited solubility, rapid metabolism, and scarce in vivo validation constrain clinical translation. Future efforts should focus on advanced formulations, multi-omics approaches, and cancer stem cell models to better define its therapeutic potential and safety. - Source: PubMed
Publication date: 2026/06/05
Alarcón AndrésMeza CatherineAñazco CarolinaSepúlveda MarcelaAlarcón SebastiánValdivia Sharin - A yeast cell template technology is described to biomimetically synthesize FeTi oxides. The resulting samples, yeast FeO and yeast FeO/TiO, are then employed as active materials for the electrochemical detection of cancer-associated miRNAs. For the perfect matched cancer miR-141, electrochemical analysis shows a main oxidation peak at about +0.4 V, along with a reduction peak at about +0.30 V. For the detection of cancer miR-29c, the introduction of the Ti element is found to stabilize the structure of the resulting materials. These results suggest a potential of the biomimetic FeTi oxides as promising sensing materials for miRNA electrochemical biosensors. - Source: PubMed
Publication date: 2026/05/23
Cui JingjieYu TaoChen Shaowei - The miR-29 family (miR-29a, miR-29b, and miR-29c) demonstrates context-depend-ent roles in cancers associated with oncogenic viruses (HPV, HBV/HCV, EBV, and HTLV-1), which collectively contribute to 15-20% of human malignancies. This comprehensive review ex-amines evidence that miR-29 primarily functions as a tumor suppressor by targeting DNMT3A, PTEN, and MCL-1, thereby regulating proliferation, apoptosis, and metastasis, though it exhibits paradoxical oncogenic activity in specific contexts, such as HBV-related Hepatocellular Carci-noma (HCC). Clinical data reveal virus-specific expression patterns: miR-29a is consistently downregulated in HPV-driven cervical tissues (progressively from CIN2/3 to invasive carci-noma), but circulating miR-29 members show diagnostic utility in viral hepatocellular carcinoma. The family displays dual roles in EBV pathogenesis, suppressing Burkitt's lymphoma through TCL1 inhibition yet promoting nasopharyngeal carcinoma metastasis via extracellular matrix dis-ruption. Current evidence supports miR-29's potential as a biomarker across multiple virus-asso-ciated cancers, with clinical utility in risk stratification and disease monitoring. While preclinical studies demonstrate that miR-29 restoration can inhibit tumor progression and reduce fibrosis in cell and animal models, significant challenges remain in delivery optimization and context-spe-cific application before clinical translation. Longitudinal validation studies and standardized de-tection methodologies are needed to establish the precise diagnostic and therapeutic value of miR-29 in viral oncology. - Source: PubMed
Publication date: 2026/05/07
Yousufzai Mohammad SediqNoori BezhanShahbahrami Ramin