Mouse pre-microRNA Expression Construct mir-298
- Known as:
- Mouse pre-microRNA Expression Construct mir-298
- Catalog number:
- mmir-298-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-298
Related genes to: Mouse pre-microRNA Expression Construct mir-298
- Gene:
- MIR298 NIH gene
- Name:
- microRNA 298
- Previous symbol:
- MIRN298
- Synonyms:
- hsa-mir-298
- Chromosome:
- 20q13.32
- Locus Type:
- RNA, micro
- Date approved:
- 2007-10-24
- Date modifiied:
- 2019-02-13
Related products to: Mouse pre-microRNA Expression Construct mir-298
Related articles to: Mouse pre-microRNA Expression Construct mir-298
- Triple-negative breast cancer (TNBC) is the most invasive subtype of breast cancer (BC) with high recurrence, high mortality, poor prognosis, and a lack of effective targeted therapies. This study aimed to investigate the prognostic value of lncRNA Alu-mediated p21 transcriptional regulator (APTR) in TNBC. APTR/miR-298 levels in TNBC tissues and cell lines were detected by RT-qPCR. The correlation between APTR and the prognosis of TNBC patients was analyzed by Kaplan-Meier survival analysis. The direct binding relationship between APTR and miR-298 was verified with a luciferase reporter assay. CCK-8 and Transwell assays were conducted to elucidate the role of APTR knockdown and miR-298 co-knockdown in regulating the viability and migration of TNBC cells. APTR was upregulated in TNBC tissues and cell lines, while miR-298 was downregulated. High APTR expression was closed associated with poor prognosis of TNBC patients. Mechanistically, APTR directly binds to and negatively regulates miR-298. Functional experiments showed that knockdown of APTR significantly inhibited the viability and migration of TNBC cells, while miR-298 inhibition partially abrogated these tumor-suppressive effects. APTR is upregulated in TNBC and is closely related to poor prognosis. APTR exerts an oncogenic role in TNBC by negatively regulating miR-298, suggesting that APTR serves as a promising novel prognostic biomarker for TNBC. - Source: PubMed
Publication date: 2026/08/18
Zhao HuinanFu QiangGong WenYu MiaoLi Huixuan - Chronic neuroinflammation has become a major concern due to its ability to propagate into multiple neurodegenerative disorders which severely reduce the life expectancy of the patients. Many molecular targets have been identified which include amyloid beta (Aβ) peptides and oligomers, protofibrils, tau proteins, MID1/ TRIM18, Beclin1 protein, Puma, NMDA receptors, RyanR2, 5-HT2B, α7nAChR, TLR4, ERRα, CysLT(1)R, PDGFβR, DRD1, β2-AR, caspases, calpain, cytochrome c, CDK5, p38-MAPK, BACE1, γ-secretase, 5-lipoxygenase, NADPH oxidase 2 and 4, JNK, MMPs, NLRP3, GSAP, PARP-1, PARG, TRPM2, HO, NO (excess), LTB4, LTD4, NF-κB (NF-kBp50/RelA dimers and NF-κB p65), TNF-α,IL-1β, IL-6, IL-10, ApoE2, ApoE4, Bax,Bcl-2, miR-9, miR-29, miR-29a/b-1, miR-101, miR-124, miR-107, miR-298, miR-149, miR-328, miR-34a-5p, miR-15b, miR-16, miR-125b-5p, miR-124, and miR-374b-5p, miR-181c-5p, linc00507, LncRNA 51A, LncRNA 17A, LncRNA BC200, LncRNA NDM29, LncRNA NEAT1, LncRNA EBF3-AS, LncRNA NAT-Rad18, LcRNA TUG1, LncRNA MALAT1, LncRNA WT1-AS, LncRNA MAGI2-AS3, XBP-1, SERCA, Na/Caexchanger, plasma-membrane Ca-ATPase, HSP27, mtHSP60/HSPD1-mtHSP10/HSPE1, HSPD1, HSPE1, HSP70, Hsp90, Sirt1, Sirt3, TIMP-123 (composite of TIMP-1, TIMP-2, and TIMP-3), TIMP-4, AChEI, BDNF. Identification of the molecular targets enabled the identification of phytoconstituents which could modulate majority of these molecular targets. A herbal formulation which is expected to alleviate neuroinflammation includes many phytoconstituents such as curcumin, (-)-epigallocatechin-3-gallate, baicalein, baicalin, resveratrol, cis-resveratrol, berberine, quercetin, apigenin, corosolic acid, ursolic acid, oleanolic acid, luteolin, albigenin, withanolide A, celastrol, gallotannin, nobotanin B, kaempferol, naringenin, rutin, withaferin A, crocetin, katsumain H, geranylgeranylacetone and huperzine. A compatibility study with different phytoconstituents will determine the suitability of the formulation. - Source: PubMed
Publication date: 2026/05/20
Paul Deepraj - Coronary artery disease (CAD) is a leading cause of death worldwide, caused by environmental factors and characterized by the formation of atherosclerotic plaques. Identification of novel biomarkers is essential for early diagnosis and risk stratification. This study aimed to investigate the expression of DEFA4 and its associated microRNAs in CAD patients and their association with demographic, clinical, and laboratory parameters. - Source: PubMed
Publication date: 2026/06/30
Rostaminiya RoyaKariminik AshrafBabaei NahidGhaleh Hadi Esmaeili Gouvarchin - Obesity and metabolic dysfunction associated steatotic liver disease (MASLD) are interrelated metabolic disorders characterized by chronic inflammation, insulin resistance, and dyslipidemia. While both conditions are well recognized clinically, the molecular mechanisms underlying their frequent coexistence remain poorly understood. Growing evidence indicates that circulatory exosomal microRNAs (miRNAs) act as critical mediators of inter-organ communication. In this PROSPERO-registered systematic review (CRD420251017335), we integrated clinical evidence with bioinformatics analyses to clarify shared miRNA-mediated regulatory networks between obesity and MASLD. Literature was retrieved from MEDLINE, ISI Web of Science, and Embase. Bioinformatics analysis using miRWalk also revealed shared miRNAs, predicted target genes, and elucidated enriched pathways using Gene Ontology and KEGG. Clinical studies identified 93 obesity-associated and 24 MASLD-associated exosomal miRNAs, with and emerging as common nodes. Bioinformatics analysis using miRWalk revealed extensive overlap at the functional level, including 40,410 shared miRNA-mRNA interactions and 42 common target genes. Several circulating exosomal miRNAs from obese individuals, including , , , and , were consistently associated with liver histopathology, inflammatory markers, and liver enzyme levels. Importantly, obesity-derived , , and showed strong diagnostic performance (AUC ≥ 0.85), exceeding that of alanine aminotransferase (ALT). Furthermore, emerged as a central therapeutic target within the shared miRNA network, regulated by both and , providing a molecular link between adipose tissue dysfunction and hepatic metabolic regulation. This integrative analysis supports a unified model in which exosomal miRNAs serve as key molecular intermediaries connecting obesity and MASLD. - Source: PubMed
Publication date: 2026/05/22
Mo QiguiGhafourian AmirrezaHamdi MasoomehAlidadipour ArianSoleimani MahdiehDavoudi MaryamMiao XiaoleiAfrisham RezaBagherieh Molood - Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly NAFLD, includes a range of conditions from steatosis to hepatocellular carcinoma and poses a significant health and economic burden. Circulating microRNAs (miRNAs) are key regulators of metabolic and inflammatory pathways involved in MASLD. However, their clinical utility as non-invasive biomarkers remain unclear. This review aims to clarify their diagnostic, prognostic, and therapeutic potential, addressing current gaps in the literature. - Source: PubMed
Publication date: 2025/07/16
Tobaruela-Resola Ana LuzMilagro Fermín IMogna-Pelaez PaolaMoreno-Aliaga María JesúsAbete ItziarZulet María Ángeles