Mouse pre-microRNA Expression Construct mir-2861
- Known as:
- Mouse pre-microRNA Expression Construct mir-2861
- Catalog number:
- mmir-2861-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-2861
Related genes to: Mouse pre-microRNA Expression Construct mir-2861
- Gene:
- MIR2861 NIH gene
- Name:
- microRNA 2861
- Previous symbol:
- -
- Synonyms:
- hsa-mir-2861
- Chromosome:
- 9q34.11
- Locus Type:
- RNA, micro
- Date approved:
- 2010-04-30
- Date modifiied:
- 2019-02-21
Related products to: Mouse pre-microRNA Expression Construct mir-2861
Related articles to: Mouse pre-microRNA Expression Construct mir-2861
- Validate the clinical utility of exosome cargo (miRNAs/proteins) and NLRP3/BDNF as key regulatory molecules for acupuncture-mediated spinal cord injury (SCI) recovery. From the establishment of the database to May 2025, a literature search was conducted on PubMed, and Embase, using keywords ["exosome cargo" or "exosome"], ["acupuncture" or "acupuncture and moxibustion" or "electroacupuncture" or "EA"], ["spinal cord injury" or "SCI"], ["immune regulation"], ["inflammatory reaction"], ["neuroregeneration" or "nerve"]. Including peer-reviewed studies on human/animal models, articles that do not meet the requirements are excluded. Preclinically, MSC-exosomal miR-145-5p suppressed TLR4/NF-κB signaling, reducing spinal IL-1β by 47% in SD rats. Schwann cell-exosomal MFG-E8 activated SOCS3/STAT3, increasing M2 macrophage CD206 by 63% and raising rat BBB scores by 3.8 points; Treg-exosomal miR-2861 upregulated tight junction proteins (occludin/ZO-1) to repair the blood-spinal cord barrier. Acupuncture (EA at GV14/GV4) upregulated spinal BDNF by 72% and NGF by 58% via Wnt/β-catenin, while EA at GV6/GV9 downregulated NLRP3 by 42-58% and TNF-α by 35-47%. Clinically, EA at EX-B2 increased ASIA scores by 3.2±1.1 points (Guo et al). Besides, 5x/week EA improved ASIA vs 3x/week (+6.4 points). EA+exercise reduced MAS by 1.6-2.9 points, with outcomes correlated to peripheral NLRP3 reduction, BDNF elevation, and MBI/WISCIII increases. Exosome cargo (miR-145-5p/MFG-E8) and NLRP3/BDNF are key regulatory molecules underlying acupuncture-mediated SCI recovery. However, limitations (small RCT samples, heterogeneous acupuncture protocols, unstandardized exosome isolation) hinder translation. Future work should focus on standardized biomarker detection, exosome engineering, and large-scale clinical trials. - Source: PubMed
Publication date: 2026/03/18
Wang YongliangZhang JianLiu JinshengLi YuefengZhao XinyuYang Zhixin - The study aimed to was to investigate the relationship between miR-2861, miR-5011-5p, and colorectal carcinogenesis. - Source: PubMed
Publication date: 2025/01/02
Aytekin AlperKadakal HikmetMihcioglu DenizGurer Turkan - - Source: PubMed
Publication date: 2024/11/20
Park Seong-HoKim JungwooYang Hee-JinLee Ju YeonKim Chi HeonHur Junho KPark Sung Bae - We investigated the regulation of histone deacetylases (HDACs) by miR-2861 in the osteoblastic differentiation of human mesenchymal stem cells (MSCs) and miR-2861 binding site by CRISPR activation (CRISPRa). Transfection of miR-2861 into human MSCs was performed and the effect on osteoblast differentiation was analyzed. Using catalytically inactive Cas12a, the CRISPRa system induced targeted overexpression of endogenous miRNA and repressed the luciferase activities of reporters that contained functional miRNA target sites. The delivery of miR-2861 into MSCs enhanced osteoblast differentiation by decreased expressions of the HDAC1, 4 and 5 genes. The mechanism of HDAC5 repression by miR-2861 in humans has not been fully elucidated. To this end, the HDAC5 mRNA sequence was analyzed and a putative primate-specific miR-2861 binding site was identified in the 3' untranslated region (3'-UTR). CRISPRa was applied to validate the putative binding site and an increase in endogenous miR-2861 was found to repress the expression of a reporter that contained the novel miR-2861 binding site. The delivery of miR-2861 to human MSCs enhanced osteoblast differentiation. In the 3'-UTR, the HDAC5 repression was mediated by the miR-2861 binding site, and miR-2861 promoted osteoblast differentiation via the inhibition of HDAC5 through a primate-specific miRNA binding site. Therefore, miRNAmiR-2861 with the CRISPRa methods might be a good biomaterial for osteogenesis augmentation. - Source: PubMed
Publication date: 2024/11/06
Park Seong-HoKim JungwooYang Hee-JinLee Ju YeonKim Chi HeonHur Junho KPark Sung Bae - Although anti-VEGF and retinal laser photocoagulation are two therapeutic modalities that have been used in the clinical treatment of diabetic retinopathy (DR), it is unknown how these modalities target vascular endothelial function in DR. - Source: PubMed
Publication date: 2024/08/05
Shi QiqinWang QiangshengMao KeLiu ZhuoranWang Ruobing