Mouse pre-microRNA Expression Construct mir-212
- Known as:
- Mouse pre-microRNA Expression Construct mir-212
- Catalog number:
- mmir-212-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-212
Related genes to: Mouse pre-microRNA Expression Construct mir-212
- Gene:
- MIR212 NIH gene
- Name:
- microRNA 212
- Previous symbol:
- MIRN212
- Synonyms:
- hsa-mir-212
- Chromosome:
- 17p13.3
- Locus Type:
- RNA, micro
- Date approved:
- 2004-04-23
- Date modifiied:
- 2019-01-18
Related products to: Mouse pre-microRNA Expression Construct mir-212
Related articles to: Mouse pre-microRNA Expression Construct mir-212
- To investigate the underlying mechanism of gene overexpression in patients with acute myeloid leukemia (AML) and to clarify the role of miR-212 in the pathogenesis of AML. - Source: PubMed
Xu JingDuan YuWang Jin-JuanCui Xiao-HuaLiu Jian-BingHao Jian-QingRen Fang-Gang - Frontotemporal dementia (FTD) is a neurodegenerative disease that shares numerous clinical features with other forms of dementia. In this context, non-coding RNAs, specifically microRNAs (miRNAs), represent a promising tool for differential diagnosis. Since these miRNAs can be isolated from circulating extracellular vesicles (EVs) in peripheral blood, they provide a direct insight into FTD-specific molecular processes. Consequently, while EV-contained miRNAs hold potential as disease-specific biomarkers, investigating their relative target genes can help elucidate their precise functional roles. : This work aimed to identify a specific miRNA signature to better characterize FTD pathology. : Building on a previous Next-Generation Sequencing (NGS) analysis, three candidate miRNAs were selected for validation in both EVs and peripheral blood mononuclear cells (PBMCs) of FTD patients. Subsequently, the predicted target genes of two of these miRNAs were validated in PBMCs to assess their expression levels. : Our findings revealed that miR-365a-3p and miR-212 were significantly down-regulated in FTD. : Together with their target genes, these miRNAs are involved in cell cycle and apoptotic pathways, suggesting a potential role in the pathological mechanisms of the disease. - Source: PubMed
Publication date: 2026/08/13
Minucchi EvelyneDragoni FrancescaDi Gerlando RosalindaPavanello GaiaCotta Ramusino MatteoCosta AlfredoGagliardi Stella - Regular physical exercise promotes brain plasticity and cognitive functions; however, many individuals with neurological or neuropsychiatric impairments face barriers that limit adherence to exercise-based interventions. Exercise-induced microRNAs (miRNAs) have emerged as potential regulators of activity-dependent signaling pathways associated with brain health. Using a voluntary wheel-running mouse model, we identified hippocampal miRNAs responsive to five weeks of exercise in both male and female mice. Small RNA sequencing detected 698 hippocampal miRNAs. Although overall hippocampal miRNA expression profiles were not significantly separated by exercise status, differential expression analysis identified miR-212-3p, miR-212-5p, and miR-466d-3p as significantly upregulated following exercise after adjustment for sex. KEGG pathway analysis of 285 predicted target genes revealed enrichment in pathways related to synaptic function, neurogenesis, inflammation regulation, and tissue remodeling. To determine whether exercise-responsive miRNAs remain inducible under neuropathological conditions, we evaluated their expression in a chronic methamphetamine (METH) and EcoHIV co-exposure mouse model. Voluntary exercise significantly increased hippocampal expression of miR-212-3p, miR-212-5p, and the co-transcribed miR-132-3p in both female and male mice, whereas miR-466d-3p was no longer responsive. Exercise was also associated with reduced astrocyte activation in the caudate putamen and partial recovery of neuronal integrity, as reflected by increased NeuN immunoreactivity in the hippocampal CA1 region, although recognition memory was not significantly restored during the intervention period. Together, these findings identify the miR-212/132 cluster as a robust exercise-responsive miRNA signature that remains inducible in a chronic METH/EcoHIV mouse model and may represent a promising candidate for future studies of exercise-mimetic strategies aimed at promoting brain resilience. - Source: PubMed
Publication date: 2026/08/22
Si JuliaKim Stephanie SLevitis Daniella LianaGuenard Chauncey GPierre Erika TWilusz ConnorToborek MichalPark Minseon - MicroRNAs, small noncoding RNA molecules, are pivotal regulators of gene expression and have been increasingly implicated in the molecular mechanisms underlying addiction. In this study, we investigated microRNA expression profiles in postmortem nucleus accumbens tissue, a key brain region for reward and addiction, from individuals with 6-monoacetylmorphine confirmed heroin-associated polysubstance intoxication (6-MAM-HAPI) (n = 20) compared with non-user individuals (n = 20). Total RNA was isolated from the tissues with "RNAzol®RT," and cDNA was obtained and measured by qRT-PCR. MicroRNA expression levels were calculated by the 2 method. Our study revealed a distinct pattern of dysregulation, with downregulation of miR-132, miR-140, miR-181a, miR-206, miR-212, and miR-339-5p, alongside a significant upregulation of miR-133b in nucleus accumbens of 6-MAM-HAPI. These findings provide preliminary postmortem evidence suggesting possible miRNA expression changes in the nucleus accumbens in the context of 6-MAM-HAPI. - Source: PubMed
Publication date: 2026/07/28
Çaykara Peran BurcuAlsaadoni HaniEsen Melez İpekBüyük YalçınPençe Sadrettin - Compartmentalized CNS inflammation involving B cells is implicated in gray matter injury and disease progression in multiple sclerosis (MS). Products secreted by B cells of patients with MS can kill oligodendrocytes and neurons, a cytotoxicity conferred by their exosome-enriched extracellular vesicle (Ex En) fraction. - Source: PubMed
Publication date: 2026/06/09
Breville GautierRezk AymanWeissman SamuelEspinoza Diego AThebault SimonYamashita Luana DKim YeseulKakara MihirNedelkoska LiljanaDoyon-Reale NicoleDelucinge-Vivier CelineZuroff LeahTouil HananeStemmer PaulBenjamins Joyce ALisak Robert PBar-Or Amit