Mouse pre-microRNA Expression Construct mir-202
- Known as:
- Mouse pre-microRNA Expression Construct mir-202
- Catalog number:
- mmir-202-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-202
Related genes to: Mouse pre-microRNA Expression Construct mir-202
- Gene:
- MIR202 NIH gene
- Name:
- microRNA 202
- Previous symbol:
- MIRN202
- Synonyms:
- hsa-mir-202
- Chromosome:
- 10q26.3
- Locus Type:
- RNA, micro
- Date approved:
- 2005-07-15
- Date modifiied:
- 2019-01-31
Related products to: Mouse pre-microRNA Expression Construct mir-202
Related articles to: Mouse pre-microRNA Expression Construct mir-202
- Mechanisms regulating the transition between two consecutive reproductive cycles are complex and remain poorly understood, mostly because they involve a dialog between the ovary and the central nervous system that is difficult to disentangle. - Source: PubMed
Publication date: 2026/05/21
Roza de Abreu MarianaCardona EmilieLagarde CamilleMilhade LeoYoshizaki GoroThermes VioletteBobe Julien - [This retracts the article DOI: 10.3727/096504016X14732772150541.]. - Source: PubMed
Publication date: 2026/01/19
- Circular RNAs (circRNAs) play important regulatory roles in a variety of biological processes in mammals. Multiple birth-traits in goats are affected by several factors, but the expression and function of circRNAs in follicular development of goats are not clear. In this study, we aimed to investigate the possible regulatory mechanisms of circRNA and collected five groups of large follicles (Follicle diameter > 6 mm) and small follicles (1 mm < Follicle diameter < 3 mm) from Leizhou goats in estrus for RNA sequencing. - Source: PubMed
Publication date: 2024/09/28
Liu JieFeng GuanghangGuo ConghuiLi ZhihanLiu DewuLiu GuangbinZou XianSun BaoliGuo YongqingDeng MingLi Yaokun - Germ cell development in mammals is a complex physiological process that involves the proliferation of primordial germ cells, meiosis, and the formation of male and female gametes. Long non-coding RNA (lncRNA) is a type of RNA with more than 200 nucleotides that does not code for proteins. A small number of lncRNAs have been shown to participate in spermatogenesis in the testes and in follicular development in the ovaries, but the role of the vast majority of lncRNAs and their molecular mechanisms still need further study. LncRNA Gm2044 was identified as a differentially expressed lncRNA in mouse spermatogenesis by microarray technology. In mouse testis, lncRNA Gm2044 can act as competing endogenous RNA to regulate SYCP1 expression in GC-2 cells derived from mouse spermatocyte cells, and it can also act as a host gene for miR-202 to regulate RBFOX2 protein expression. In female mouse ovaries, lncRNA Gm2044 regulates 17β-estradiol synthesis through the miRNA-138-5p-Nr5a1 pathway or by interacting with EEF2. In addition, studies suggest that lncRNA Gm2044 is also involved in the progression of reproductive system diseases such as male nonobstructive azoospermia. Here, we summarize the roles and molecular mechanisms of lncRNA Gm2044 in male and female gametogenesis and its potential role in some infertility disorders. - Source: PubMed
Publication date: 2024/07/04
Zhu QinranSun JunpeiAn ChuangchuangLi XinXu ShuminHe YutongZhang XinyiLiu LeiHu KeLiang Meng - Traumatic and inherited cataract spiking blindness is caused by accumulated deposition of mutant eye lens protein or lens microarchitecture alteration. A traumatic cataract is a clouding of the eye's natural lens that occurs as a result of physical trauma to the eye. This trauma can be caused by various incidents such as blunt force injury, penetration by a foreign object, or a significant impact on the eye area. Inheritance cataracts or hereditary cataracts are cataracts that are genetically inherited from one or both parents. Complications following cataract surgery encompass various adverse outcomes such as inflammation, infection, bleeding, swelling, drooping eyelid, glaucoma, secondary cataracts, and complete loss of vision. The main purpose of the review is to highlight common pathophysiology associated with traumatic and inherited cataracts. Also, the review discusses diagnosis and treatment strategies for such cataract types by targeting their key pathological hallmarks. γD-crystallin plays a crucial role in maintaining the optical properties of the lens during the life span of an individual. Carbamazepine, Resveratrol, and Myricetin (CRM) are effectively bound at the cD-crystallin binding site and thereby could minimize misfolding and aggregation of γD-crystallin. miR-202, miR-193b, miR-135a, miR- 365, and miR-376a had the highest levels of abundance in the aqueous humor of individuals diagnosed with cataracts. The validation of these miRs will provide more insights into their functional roles and may be used for diagnostic purposes. The effective CRM combination as a multidrug formulation may postpone both traumatic and inherited cataracts and protect the eye from blindness. - Source: PubMed
Panda Siva PrasadPachauri NavneetKesharwani AdarshPrasanth Dintakurthi S N B KSingh Vikrant