Mouse pre-microRNA Expression Construct mir-193b
- Known as:
- Mouse pre-microRNA Expression Construct mir-193b
- Catalog number:
- mmir-193b-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-193b
Related genes to: Mouse pre-microRNA Expression Construct mir-193b
- Gene:
- MIR193B NIH gene
- Name:
- microRNA 193b
- Previous symbol:
- MIRN193B
- Synonyms:
- hsa-mir-193b
- Chromosome:
- 16p13.12
- Locus Type:
- RNA, micro
- Date approved:
- 2005-07-15
- Date modifiied:
- 2019-01-30
Related products to: Mouse pre-microRNA Expression Construct mir-193b
Related articles to: Mouse pre-microRNA Expression Construct mir-193b
- Bladder cancer (BlCa) surveillance requires lifelong invasive monitoring, imposing substantial patient burden and healthcare costs. This underscores the need for minimally-invasive precision medicine approaches. Herein, we investigated the circulating miRNome of BlCa patients to assess its clinical and translational utility. - Source: PubMed
Publication date: 2026/08/09
Papadimitriou Maria-AlexandraPilala Katerina-MarinaPanoutsopoulou KonstantinaSoureas KonstantinosGiagkos Georgios-ChristosLevis PanagiotisKanaki ZoiLoules GedeonZamanakou MariaStravodimos KonstantinosKlinakis ApostolosAvgeris MargaritisScorilas Andreas - Alzheimer's disease (AD) is a progressive neurodegenerative disorder, and its diagnosis emains challenging. Exosomal microRNAs (miRNAs), due to their stability, tissue specificity, and ability to cross the blood-brain barrier, show significant promise as ideal biomarkers for AD. The present study aimed to systematically elucidate the relationship between the exosomal miRNA expression changes and AD pathogenesis (including Aβ deposition, Tau protein phosphorylation, and neuroinflammation) and to evaluate their potential utility in clinical screening and therapeutic interventions. A systematic literature search was conducted in the PubMed and Web of Science databases to identify human case-control or cohort studies reporting expressions of mature exosomal miRNAs in the serum, plasma, cerebrospinal fluid, saliva, or central nervous system cells. After evaluating the quality of the studies using the National Institutes of Health quality assessment tool, the identified differentially expressed miRNAs were summarized and functionally integrated. Among the 390 screened records, 48 studies (n = 3046 AD patients) met the inclusion criteria. The analysis identified 120 exosomal miRNAs that are differentially expressed at different AD ages. Six miRNAs (miR-125b, miR-146a, miR-193b, miR-185-5p, miR-29b/c, miR-21-5p) were most consistently reported and showed significant correlation with AD pathology. - Source: PubMed
Publication date: 2026/04/15
Zhou HaiqingLiu YingLi KaijunMou ShangdongCao XiaChen Qingjuan - Aberrant expression of Homeobox () genes has been observed in acute myeloid leukemia (AML), but their epigenetic regulatory mechanisms remain largely elusive. Previously, we identified hypomethylation, among family genes as an epigenetic biomarker for predicting clinical outcomes and guiding treatment choices in AML. Herein, we further investigated the methylation of family members in AML and determined its clinical implications. - Source: PubMed
Publication date: 2026/01/12
Zhang Ting-JuanChang RanXie FeiXu Zi-JunChu Ming-QiangWu Xiao-ChiQian JunZhou Jing-Dong - MicroRNAs (miRNAs) have emerged as pivotal regulators of gene expression, fundamentally influencing cellular processes such as proliferation, differentiation, and apoptosis. Among these, miR-193b has garnered significant attention as a potent tumor suppressor in some contexts, while functioning as an oncogene in other situations. Its frequent loss in some types of cancers such as gastric and cervical cancers as well as osteosarcoma positions it not only as a valuable prognostic indicator but also as a potential tool for gene therapy. On the other hand, it has been found to be up-regulated in esophageal and bladder cancers. Meanwhile, data regarding its expression pattern in some types of cancers, such as colorectal, lung and pancreatic cancers is conflicting. Moreover, its influence extends beyond oncology, implicating it in a diverse range of human diseases, including systemic sclerosis, aortic dissection, osteoarthritis, diabetes, psoriasis, Parkinson's disease, Alzheimer's disease, sepsis and allergic rhinitis. However, miR-193b does not have a single, unified function; instead, its role is highly context-dependent, acting as either a protective molecule or a pathogenic driver depending on the specific tissue and disease. This review aims to consolidate the current updates on the role of miR-193b, detailing its molecular mechanisms, validated target genes, and its burgeoning potential as a diagnostic biomarker and therapeutic agent in cancer and other pathological conditions. - Source: PubMed
Publication date: 2025/12/02
Khalilian SheydaFathi MohadesehArezi SaraGhafouri-Fard Soudeh - Prediabetes in individuals with obesity is a high-risk state for progression to type 2 diabetes mellitus (T2DM). Circulating microRNAs (miRNAs) have emerged as promising minimally invasive biomarkers for early detection. However, their diagnostic performance and consistency across studies remain unclear. - Source: PubMed
Keng-Lim Brenda WenChen-Ng Kelvin YeeYee-Lee JiaHsein-Chen ChingLing-Chang WanYian-Koh RhunPhilip-Kunnath AnilMoi-Chye Soi