Mouse pre-microRNA Expression Construct mir-187
- Known as:
- Mouse pre-microRNA Expression Construct mir-187
- Catalog number:
- mmir-187-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-187
Related genes to: Mouse pre-microRNA Expression Construct mir-187
- Gene:
- MIR187 NIH gene
- Name:
- microRNA 187
- Previous symbol:
- MIRN187
- Synonyms:
- hsa-mir-187
- Chromosome:
- 18q12.2
- Locus Type:
- RNA, micro
- Date approved:
- 2004-04-23
- Date modifiied:
- 2019-01-31
Related products to: Mouse pre-microRNA Expression Construct mir-187
Related articles to: Mouse pre-microRNA Expression Construct mir-187
- MicroRNAs (miRNAs) are small non-coding RNAs that play crucial regulatory roles in gene expression in metazoans. While the miRNA repertoire and relative abundances have been extensively studied in terrestrial mammals, no information was available for the milk of marine mammals. Here, we present the first characterization of the miRNA genomic landscape and abundance in milk in the bottlenose dolphin (Tursiops truncatus). Using a sequence-based comparative approach, we identified 186 conserved miRNA families comprising 354 high-confidence precursors in the dolphin genome. Comparative analysis across 52 cetacean genomes revealed a small number of lineage-specific loss events, such as mir-187 in Delphinidae, and the absence of nine miRNA families in all cetaceans. Small RNA sequencing from pooled milk samples confirmed the detectable abundance of 119 miRNAs, with a landscape dominated by mir-148, let-7, mir-8, and mir-21, collectively accounting for over 70% of total miRNA reads. These dominant families include miRNAs frequently reported in the milk of terrestrial mammals, suggesting qualitative similarity in the major milk miRNA repertoire between dolphin and terrestrial mammals. These findings should be interpreted as a first sequencing-supported exploratory characterization of dolphin milk miRNAs. - Source: PubMed
Publication date: 2026/09/09
Cendron FilippoBoselli CarloMaggi FlavioDuri AnnalisaD'Onofrio ValentinaDe Marchi MassimoPenasa MauroRosani Umberto - Canine mammary gland tumours (MGT) represent a common malignancy in intact female dogs, with a high metastasis rate approaching 50% and a poor prognosis. However, metastasis-related genes remain largely unelucidated. Accordingly, we aimed to identify differentially expressed mRNAs and miRNAs in primary canine MGT tissues from dogs with or without confirmed metastasis. We compared mRNA and microRNA (miRNA) expression profiles between malignant MGT tissue samples with and without metastasis. Differentially expressed genes and miRNAs were identified using next-generation sequencing and analysed using the Empirical Analysis of DEGs tool within CLC Genomics Workbench. We identified 119 genes and eight miRNAs as differentially expressed in primary MGTs from dogs with confirmed metastasis. The RIPPLY1 gene was significantly downregulated in primary MGT samples with confirmed metastasis and this result was validated by RT-qPCR. The Cancer Genome Atlas (TCGA) database showed decreased RIPPLY1 expression in human breast cancer, supporting its possible relevance to tumour biology. In silico analysis (miRWalk) revealed that miR-187 is a predicted candidate miRNA that may interact with RIPPLY1 and both NGS data and RT-qPCR showed increased cfa-miR-187 expression in primary tumour samples from dogs with confirmed metastasis. The inverse expression pattern of RIPPLY1 and cfa-miR-187, together with RNAhybrid binding prediction, suggests a possible candidate miRNA-mRNA relationship. STRING analysis suggested a possible pathway context involving beta-catenin/TCF-related proteins, but this computational result requires further validation. Based on these findings, we identified RIPPLY1 and cfa-miR-187 as potential candidate transcripts associated with primary canine MGTs from dogs with confirmed metastasis but functional validation is required. - Source: PubMed
Publication date: 2026/07/03
Wang ShaohsuTakahashi MasashiChen Hui-WenNozaki NobuhiroArif MohammadIde YutaroAkiyama YoshiyukiIslam SirazulHifumi TatsuroHirano ShinjiMiyoshi NoriakiYamato OsamuKato DaikiNakagawa TakayukiMiura Naoki - Tumor-infiltrating lymphocytes are prognostic and predictive biomarkers of breast cancer; however, conventional assessment is hindered by invasiveness and subjective evaluation, limiting clinical reproducibility. This study investigated the utility of microRNA (miRNA) profiles in predicting lymphocyte-predominant breast cancer (LPBC). - Source: PubMed
Kai AzusaArihiro KojiShigematsu HideoOhue-Uchihata YukariNakamura MomokoAmioka AiSasada ShinsukeOkada Morihito - Our labs have demonstrated exercise is protective in animal models of retinal degeneration (RD). Inflammation drives RD progression, and is regulated by the recruitment and reactivity of glia cells as well as through small non-coding RNAs, microRNAs (miRNAs). Here, we explore the effects of treadmill exercise on the recruitment and reactivity of retinal inflammatory cells within the neural retina and miRNA expression in a light-induced retinal degeneration model (LIRD) that exhibits phenotypes found in patients with RD. - Source: PubMed
Publication date: 2025/07/21
Haupt HaydenChen Vivian SPalumaa TeeleAnderson Teresa ERodriguez Gabriela SanchezChu-Tan JoshuaNatoli RiccardoFeola Andrew JNickerson John MPardue Machelle TBoatright Jeffrey HBales Katie L - The current study assessed the impact of self-reported stress measures on microRNA (miRNA) profiles in saliva exosomes. Saliva is one of the most accessible and non-invasive bodily fluids and exosomal miRNAs in saliva could be useful in (1) measuring stress states and (2) distinguishing between individuals suffering from high levels of chronic stress vs. adverse childhood experiences (ACEs). miRNAs are small, noncoding RNAs that act as gene regulators. Several studies have shown differential expressions of certain miRNA in neurological diseases and in stress, post-traumatic stress syndrome (PTSD) and anxiety. Detailed analyses of miRNA expressions and profiling of miRNAs among populations with various exposures to traumatic and life stressors have not been carried out. The goal of our study was to discover miRNAs associated with high chronic stress or childhood trauma. - Source: PubMed
Publication date: 2025/02/14
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