Mouse pre-microRNA Expression Construct mir-154
- Known as:
- Mouse pre-microRNA Expression Construct mir-154
- Catalog number:
- mmir-154-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-154
Related genes to: Mouse pre-microRNA Expression Construct mir-154
- Gene:
- MIR154 NIH gene
- Name:
- microRNA 154
- Previous symbol:
- MIRN154
- Synonyms:
- hsa-mir-154
- Chromosome:
- 14q32.31
- Locus Type:
- RNA, micro
- Date approved:
- 2004-04-23
- Date modifiied:
- 2019-01-31
Related products to: Mouse pre-microRNA Expression Construct mir-154
Related articles to: Mouse pre-microRNA Expression Construct mir-154
- Noncoding RNAs (ncRNAs) play essential roles in mammalian gene regulation, yet their copy number evolution across mammals remains poorly characterised. Here, using high-confidence Covariate Models (CMs) from Rfam, we applied a unified INFERNAL-based framework to systematically predict copy numbers of 588 well-curated, conserved ncRNA gene families across 60 mammalian genomes. Phylogenetic correlation tests indicated that variation in ncRNA family number and total copy numbers is largely independent of genome size, scaffold number, or assembly completeness, indicating that lineage-specific evolutionary processes, rather than genome characteristics, primarily shape ncRNA copy number diversity. Using CAFE analysis, we inferred a burst of ncRNA expansions in the eutherian ancestor, predominantly involving snRNA and H/ACA snoRNA families. In contrast, estimates of phylogenetic signals (Pagel's λ) and evolutionary rates (σ) revealed that many miRNA families exhibit lineage-specific copy number expansions. Analysis of highly variable ncRNA families further showed frequent overlap with transposable elements and distinct duplication strategies, including tandem clustering (e.g., mir-154 and SNORA116) and dispersed distributions with regional tandem duplications (e.g., 5S_rRNA). Collectively, these results provide a comparative overview of copy number variation among conserved ncRNA families in mammals. While individual predicted copies may include pseudogenised or TE-derived loci, our analyses reveal robust evolutionary patterns at the family level and provide a foundation for future studies of ncRNA duplication and diversification. - Source: PubMed
Publication date: 2026/05/22
Yang ZeweiHuang Zixia - As human space exploration accelerates, understanding the organism-wide molecular effects of longer spaceflight in mammals becomes increasingly critical. Non-coding RNAs like miRNAs are key to regulating this landscape. We thus analyze 686 small RNA samples of female mice from 13 solid organs at 3 and 8 months of age, after at least 3 weeks on the International Space Station and compare them to earth-bound controls. We observe significant spaceflight effects in systemic tissue remodeling pathways along the Fat-Liver-Pancreas axis and in heart, brain, spleen and thymus. The MIR-17/92 and MIR-1/133 families drive distinct molecular changes through specific gene targeting. Age-dependent changes, smaller in magnitude compared to age-independent changes, primarily involve tissue remodeling through MIR-8, MIR-154 and MIR-15 families in mesenteric adipose tissue, pancreas, and diaphragm. Our findings provide evidence on how spaceflight regulates mammalian gene expression in preparation for interplanetary spaceflight. - Source: PubMed
Publication date: 2026/02/05
Grandke FriederikeRishik ShusrutoWagner ViktoriaEngel AnnikaLudwig NicoleCalcuttawala KrutiKern FabianKeller VerenaKrawczyk MarcinStodieck LouisFerguson VirginiaRoberts AmandaMeese EckartSchaum NicholasQuake StevenWyss-Coray TonyKeller Andreas - This study aimed to investigate the possible mechanism through which acupuncture protects ovaries with Poor Ovarian Response (POR) in rats based on microRNA (miRNA). - Source: PubMed
Liu YunzhuYang WanqiuYuan RongliLi ZimengWang TianyuYang BinLi ZhiWang MengjingWu Jie - MicroRNAs (miRNAs) are a type of specific molecules that control the activities of the uterus, such as the process of cellular maturing and evolution. A lot of substances like growth factors, cytokines, and transcription factors play a role in embryo-endometrial interaction. MiRNAs could regulate various these factors by attaching to the 3' UTR of their mRNAs. Moreover, current research show that miRNAs participate in formation of blood vessels in endometrium (miR-206, miR-17-5p, miR-16-5p…), decidualization (miR-154, miR-181, miR-9…), epithelial-mesenchymal transition (miR-30a-3p), immune response (miR-888, miR-376a, miR-300…) embryo attachment (miR-145, miR-27a,451…) and pinopod formation (mir-223-3p, mir-449a, mir-200c). In this study, the focus is on the role of miRNAs in managing the uterus' receptivity to an embryo and its ability to facilitate attachment. More specifically, we are exploring the mechanisms by which miRNAs regulate the presence of specific molecules involved in this crucial physiological process. - Source: PubMed
Publication date: 2024/11/11
Salmasi SoheilaHeidar Mohammad SaeedKhaksary Mahabady MahmoodRashidi BahmanMirzaei Hamed - - Source: PubMed
Zhang SaiChen Zhi XianZhang MoDu YanZhou Jia YiWu JingYu Yin HuaCao QiZhao Hong Bo