Mouse pre-microRNA Expression Construct mir-135b
- Known as:
- Mouse pre-microRNA Expression Construct mir-135b
- Catalog number:
- mmir-135b-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-135b
Related genes to: Mouse pre-microRNA Expression Construct mir-135b
- Gene:
- MIR135B NIH gene
- Name:
- microRNA 135b
- Previous symbol:
- MIRN135B
- Synonyms:
- hsa-mir-135b
- Chromosome:
- 1q32.1
- Locus Type:
- RNA, micro
- Date approved:
- 2004-07-22
- Date modifiied:
- 2019-01-30
Related products to: Mouse pre-microRNA Expression Construct mir-135b
Related articles to: Mouse pre-microRNA Expression Construct mir-135b
- Arrhythmogenic cardiomyopathy (ACM/ARVC) is an inherited myocardial disease characterized by progressive fibro-fatty replacement, ventricular arrhythmias, and an increased risk of sudden cardiac death. In addition to mutations in desmosomal genes, growing evidence suggests that microRNAs (miRNAs) actively contribute to disease pathogenesis by regulating key processes such as fibrosis, cell adhesion, and cardiac remodeling. This systematic review analyzed the main miRNAs identified in studies of human cardiac tissue and animal models of ARVC. - Source: PubMed
Publication date: 2026/06/22
Napoletano GabrieleGhamlouch AlessandroRacciatti MauraSonnini ElenaTreves BiancamariaDe Angelis GaiaMontalto Filippo AlessandroMaiese AnielloLa Russa RaffaeleFrati PaolaDe Matteis Alessandra - BackgroundmiRNAs are of interest due to have been involved in cancers such as colorectal cancer (CRC).ObjectiveTo explore the expression levels of miRNA-34a and miRNA-135b and whether they can be potential biomarker for early diagnosis of CRC.MethodsFifteen pairs newly diagnosed colorectal cancer and normal involved in the measurement of tissue and serum levels of miRNAs 34a and 135b and their target genes of SIRT1 and DAPK-1. We assessed the predictive value of these miRNAs utilizing the receiver operating characteristic curve.ResultsThe findings have shown that the miRNA-34a expression was significantly downregulated and miRNA-135b was upregulated in CRC tissues in comparison to their expression in adjacent normal tissue. This was additionally observed in the serum of the same CRC cases when compared to individuals without CRC. Furthermore, we found a significant increase in the level of SIRT-1 and a significant reduction in the expression level of DAPK-1 in CRC tissues compared to the adjacent normal tissue. The value of AUC was considerably high for the timely detection of CRC.ConclusionsWe found these miRNAs acting as potential non-invasive biomarkers for the early detection of CRC and in assessing the CRC risk within the general population. - Source: PubMed
Publication date: 2026/06/10
Karami RoyaNajafi ElahehBabaei AnahitaShahdoust ErfanShaghaghi AliAmiri-Dashatan NasrinMotlagh BehroozKoushki MehdiKhodabandehloo Hadi - [This retracts the article DOI: 10.3727/096504017X14850182723737.]. - Source: PubMed
Publication date: 2026/05/21
- MicroRNAs (miRNAs) play pivotal roles in glioblastoma (GBM) progression and therapy resistance. Among them, miR-25-3p has emerged as a key oncogenic miRNA that promotes tumor growth, invasiveness, and resistance to temozolomide (TMZ). In this study, we profiled miRNA expression in primary GBM specimens (n = 50) stratified by MGMT methylation and TP53 mutation status and assessed the functional impact of miR-25-3p inhibition in seven patient-derived GBM cell lines. Quantitative PCR analysis revealed upregulation of miR-135b in MGMT-methylated tumors and miR-10b in TP53-mutant cases. Both miR-25-3p and miR-10b were significantly elevated in 3D spheroid cultures compared to 2D monolayers. Notably, both miRNAs were secreted via tumor-derived extracellular vesicles, implicating a role in cell-cell communication. Inhibition of miR-25-3p in GBM cell lines consistently suppressed β-catenin and re-induced FBXW7 expression across all cases, correlating with inhibitor uptake. In four of seven cell lines, miR-25-3p inhibition enhanced TMZ sensitivity and reduced invasiveness, although the anti-invasive effect was not further potentiated by the addition of TMZ. In addition, RNA-Seq and methylome analyses revealed genetic and epigenetic reprograming toward a less aggressive, less invasive phenotype with reduced stemness potential. These findings highlight the interplay between tumor microenvironment and molecular heterogeneity in shaping miRNA dynamics in GBM. Collectively, our results identify miR-25-3p as a promising dual-action therapeutic target to mitigating both invasion and chemoresistance in GBM, warranting further translational investigation. - Source: PubMed
Publication date: 2026/05/30
Richter KatharinaMarkmann HannahKaps PhilippWolff AnnabellSimm StefanDubinski DanielGessler FlorianFreiman Thomas MKirschstein TimoJunghanss ChristianMaletzki ClaudiaSchneider Bjoern - Parkinson disease (PD) is a progressive neurodegenerative disorder characterized by the selective loss of dopaminergic neurons in the substantia nigra pars compacta and pathological accumulation of α-synuclein in Lewy bodies. In this process, a set of non-coding RNAs including miRNAs, lncRNAs, and circRNAs form key regulatory layers in the pathogenesis of the disease and directly affect α-synuclein homeostasis, mitochondrial function, oxidative stress, neuroinflammation, autophagy, and proteostasis. Dysregulation of miRNAs targets neurosensitive pathways; miR-7 and miR-153 inhibit SNCA translation, miR-27a/b and miR-103a-3p regulate the PINK1/Parkin axis in mitophagy, and miR-155, together with miR-135b, modulate the regulation of the NF-κB/NLRP3 dependent inflammasome. On a broader level, lncRNAs with destructive roles such as NEAT1, HOTAIR, MALAT1, SNHG1, UCA1 and GAS5 increase α-synuclein accumulation and impair autophagy through ceRNA and chromatin remodeling mechanisms. On the other hand, circRNAs with their stable circular structure alter posttranslational regulation through miRNA sponging; such that circSNCA, CDR1as and circSLC8A1 enhance α-synuclein load, impair mitophagy and exacerbate oxidative stress, while circDLGAP4 has a neuroprotective function. Data from single-cell sequencing and multi-omics reveal cell-specific patterns of ncRNA dysregulation in microglia, astrocytes and dopaminergic neurons, highlighting their importance in early diagnosis, molecular stratification of patients and development of targeted therapies. - Source: PubMed
Publication date: 2026/04/30
Tang PatrickJing ZiluoTong ZhengliangPeng XiangyuTong JenniferPeng Yizi