Mouse pre-microRNA Expression Construct mir-107
- Known as:
- Mouse pre-microRNA Expression Construct mir-107
- Catalog number:
- mmir-107-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-107
Related genes to: Mouse pre-microRNA Expression Construct mir-107
- Gene:
- MIR107 NIH gene
- Name:
- microRNA 107
- Previous symbol:
- MIRN107
- Synonyms:
- hsa-mir-107
- Chromosome:
- 10q23.31
- Locus Type:
- RNA, micro
- Date approved:
- 2004-04-23
- Date modifiied:
- 2019-01-30
Related products to: Mouse pre-microRNA Expression Construct mir-107
Related articles to: Mouse pre-microRNA Expression Construct mir-107
- Adult stem cells for trabecular meshwork (TMSCs) present in the non-filtering region (NF) decreased with ageing and were significantly reduced in primary open angle glaucoma (POAG). This study aimed to profile the trabecular meshwork (TM) region specific miRNAs and to analyse their expression patterns in aged and glaucomatous donor tissues. - Source: PubMed
Publication date: 2026/08/28
Nair SnehaDevarajan BharanidharanVanniarajan AyyasamyRavichandran NerethikaRamaswamy GopalakrishnaBhat VijayalakshmiRamsamy Krishnadas SubbaiahChidambaranathan Gowri Priya - Novel treatment strategies are needed to address treatment resistance and delayed onset of action in psychiatry. Psilocybin has shown promise as a treatment for major depressive disorder, but the molecular changes associated with its effects remain incompletely understood. In parallel, microRNAs (miRNAs) have been implicated in depression and in responses to antidepressant interventions. Here, adolescent female pigs were used to explore miRNA expression profiles in the prefrontal cortex (PFC) and hippocampus (HIP) 1 day and 7 days after a single dose of psilocybin. We established a conservative NanoString nCounter workflow for pig tissue using the Human v3b miRNA Assay panel, cross-species reannotation based on complete human-pig sequence conservation, and evaluation of multiple normalization strategies. Using this pipeline, 12 dysregulated miRNAs were identified in the PFC and two in the HIP 1 day after psilocybin administration, whereas four dysregulated miRNAs were detected in the HIP after 7 days. Nine of the 18 miRNAs identified across the two regions have previously been linked to depression-related phenotypes. miR-212-3p and miR-107 showed the most robust acute regulation in the PFC across all four normalization approaches. These findings indicate that psilocybin administration is associated with region- and time-dependent miRNA changes in the pig brain and support the utility of this conservative nCounter pipeline for cross-species miRNA profiling. The study is exploratory and does not establish causality or direct antidepressant mechanisms. - Source: PubMed
Publication date: 2026/08/11
Kaadt ErikSøkilde Rolf FyllgrafGarling Hanne DemantRaval Nakul RaviLundgaard LeneJust JesperKnudsen Gitte MoosElfving Betina - Chronic neuroinflammation has become a major concern due to its ability to propagate into multiple neurodegenerative disorders which severely reduce the life expectancy of the patients. Many molecular targets have been identified which include amyloid beta (Aβ) peptides and oligomers, protofibrils, tau proteins, MID1/ TRIM18, Beclin1 protein, Puma, NMDA receptors, RyanR2, 5-HT2B, α7nAChR, TLR4, ERRα, CysLT(1)R, PDGFβR, DRD1, β2-AR, caspases, calpain, cytochrome c, CDK5, p38-MAPK, BACE1, γ-secretase, 5-lipoxygenase, NADPH oxidase 2 and 4, JNK, MMPs, NLRP3, GSAP, PARP-1, PARG, TRPM2, HO, NO (excess), LTB4, LTD4, NF-κB (NF-kBp50/RelA dimers and NF-κB p65), TNF-α,IL-1β, IL-6, IL-10, ApoE2, ApoE4, Bax,Bcl-2, miR-9, miR-29, miR-29a/b-1, miR-101, miR-124, miR-107, miR-298, miR-149, miR-328, miR-34a-5p, miR-15b, miR-16, miR-125b-5p, miR-124, and miR-374b-5p, miR-181c-5p, linc00507, LncRNA 51A, LncRNA 17A, LncRNA BC200, LncRNA NDM29, LncRNA NEAT1, LncRNA EBF3-AS, LncRNA NAT-Rad18, LcRNA TUG1, LncRNA MALAT1, LncRNA WT1-AS, LncRNA MAGI2-AS3, XBP-1, SERCA, Na/Caexchanger, plasma-membrane Ca-ATPase, HSP27, mtHSP60/HSPD1-mtHSP10/HSPE1, HSPD1, HSPE1, HSP70, Hsp90, Sirt1, Sirt3, TIMP-123 (composite of TIMP-1, TIMP-2, and TIMP-3), TIMP-4, AChEI, BDNF. Identification of the molecular targets enabled the identification of phytoconstituents which could modulate majority of these molecular targets. A herbal formulation which is expected to alleviate neuroinflammation includes many phytoconstituents such as curcumin, (-)-epigallocatechin-3-gallate, baicalein, baicalin, resveratrol, cis-resveratrol, berberine, quercetin, apigenin, corosolic acid, ursolic acid, oleanolic acid, luteolin, albigenin, withanolide A, celastrol, gallotannin, nobotanin B, kaempferol, naringenin, rutin, withaferin A, crocetin, katsumain H, geranylgeranylacetone and huperzine. A compatibility study with different phytoconstituents will determine the suitability of the formulation. - Source: PubMed
Publication date: 2026/05/20
Paul Deepraj - [This retracts the article DOI: 10.21037/jtd.2020.03.103.]. - Source: PubMed
Publication date: 2026/06/26
Wei XueqiangLei YujieLi MinjieZhao GuangqiangZhou YongchunYe LianhuaHuang Yunchao - Non-small cell lung cancer (NSCLC) accounts for the majority of lung cancer cases. Circulating microRNAs (miRNAs) have emerged as promising non-invasive biomarkers for cancer detection. In this exploratory study, we investigated the diagnostic and prognostic value of four circulating miRNAs (miR-107, miR-199-3p, miR-485-5p, and miR-574-5p) in NSCLC, three of which have not previously been examined in this context. - Source: PubMed
Publication date: 2026/07/03
Serilmez MuratSen SenaOzgur EmreKaraman SuleGezer Ugur