Mouse pre-microRNA Expression Construct mir-100
- Known as:
- Mouse pre-microRNA Expression Construct mir-100
- Catalog number:
- mmir-100-pa-1
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Sbi systeme bioscience
- Gene target:
- Mouse pre-microRNA Expression Construct mir-100
Related genes to: Mouse pre-microRNA Expression Construct mir-100
- Gene:
- MIR100 NIH gene
- Name:
- microRNA 100
- Previous symbol:
- MIRN100
- Synonyms:
- hsa-mir-100
- Chromosome:
- 11q24.1
- Locus Type:
- RNA, micro
- Date approved:
- 2004-04-23
- Date modifiied:
- 2019-01-24
Related products to: Mouse pre-microRNA Expression Construct mir-100
Related articles to: Mouse pre-microRNA Expression Construct mir-100
- Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro-RNA (miRNA)-mRNA regulatory networks underlying region-specific molecular mechanisms in white matter and gray matter lesions in progressive MS. - Source: PubMed
Publication date: 2026/08/31
Sapra AdyaRai Nagendra KNiepokny Timothy DCourtney HaleyTripathi AjaiDutta Ranjan - Dairy cows are vulnerable to health problems during the transition period, associated with a negative energy balance (NEB). MicroRNAs are known to influence many biological processes including inflammation. This study aimed to evaluate the effects of nutrient restriction on liver miRNome 24 h after an intramammary lipopolysaccharide (LPS) challenge in early-lactation Holstein cows. Cows were assigned to constant lactation diet throughout the study (CONT) or were switched to a diet diluted with barley straw for 96 h (REST) starting at 24 ± 3 days in milk. In all cows, mammary inflammation was induced at 72 h by an intramammary injection of 50 μg of LPS. Blood, milk and liver biopsies were collected at 24 h post-LPS challenge and thus at 96h after nutrient restriction. In the REST group, plasma concentrations of non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB) increased. In liver, 615 known miRNAs were identified by small RNA-Sequencing. Among them, 23 miRNAs were highly expressed (>100,000 reads), representing over 91 % of total reads. We identified two miRNAs (miR-143 and let-7f) consistently abundant across cattle breeds, suggesting conserved roles in liver function. Nutrient restriction altered the expression of five miRNAs (miR-30e-5p, miR-33a-5p, miR-33b-5p, miR-100-5p and miR-210-3p), with miR-30e-5p being one of the most abundant in bovine liver. These miRNAs were correlated with milk production and composition, plasma NEFA and BHB concentrations. Functional predictions suggest that these miRNAs may regulate biological processes related to cellular processes, nucleic acid metabolism, protein processing, and metabolic and lipid processes. Three of these miRNAs (miR-30e-5p, miR-100 and miR-210) were reported to be potentially involved in immune responses. - Source: PubMed
Publication date: 2026/08/25
Faulconnier YPires J A AYe TPawlowski KLeroux C - Age-related macular degeneration (AMD) is a common degenerative eye disease that eventually leads to irreversible vision loss. CircRNAs have received increasing attention for their regulatory role in AMD. In this study, whole transcriptome sequencing identified differentially expressed circRNA (circMETTL3) in AMD. Previous studies have unlocked the potential mechanism of circMETTL3 in cancer, but its role in AMD has not been studied. - Source: PubMed
Publication date: 2026/08/20
Xin XiangyangZhao XinLing FengQin LiruLiu XinyueLiu Changhe - Gliomas, particularly glioblastoma (GBM), remain highly lethal brain tumors with limited treatments. MRI-based monitoring lacks specificity in distinguishing progression from treatment effects. Circulating microRNAs (miRNAs), small non-coding RNAs involved in tumor biology, show promise as liquid biopsy biomarkers. We searched PubMed, Embase, Scopus, and Web of Science for clinical studies investigating circulating miRNAs as diagnostic, prognostic, or predictive biomarkers in glioma, across plasma, serum, and cerebrospinal fluid (CSF). Oncogenic miRNAs (oncomiRs) such as miR-21, miR-10b, miR-182, and miR-210 were consistently upregulated in glioma patients, whereas tumor suppressors including miR-124, miR-128, miR-137, and miR-181 family members were downregulated. Prognostically, elevated miR-21, miR-222, and miR-196b correlated with poor survival, while reduced miR-181d, miR-100, and miR-145 predicted worse outcomes. Composite signatures, particularly exosomal or CSF-derived panels, outperformed single markers. Dynamic changes in miR-21, miR-222, and miR-210 reflected treatment response or progression, with exosomal miR-1238 emerging as a marker of temozolomide resistance. Longitudinal serum levels of miR-223 and miR-320e correlated with MRI tumor volume and distinguished true progression from pseudo-progression. Circulating miRNAs show strong potential as minimally invasive biomarkers for glioma management, but clinical translation remains limited by technical and biological variability and lack of validation. Advances in biosensors, multi-omics, and standardization are key to clinical integration. - Source: PubMed
Publication date: 2026/07/28
Leclerc ArthurEmery EvelyneLevallet Guénaëlle - Bladder cancer (BlCa) surveillance requires lifelong invasive monitoring, imposing substantial patient burden and healthcare costs. This underscores the need for minimally-invasive precision medicine approaches. Herein, we investigated the circulating miRNome of BlCa patients to assess its clinical and translational utility. - Source: PubMed
Publication date: 2026/08/09
Papadimitriou Maria-AlexandraPilala Katerina-MarinaPanoutsopoulou KonstantinaSoureas KonstantinosGiagkos Georgios-ChristosLevis PanagiotisKanaki ZoiLoules GedeonZamanakou MariaStravodimos KonstantinosKlinakis ApostolosAvgeris MargaritisScorilas Andreas