OCIAD1 Peptide
- Known as:
- OCIAD1 Peptide
- Catalog number:
- 5461p
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- OCIAD1 Peptide
Related genes to: OCIAD1 Peptide
- Gene:
- OCIAD1 NIH gene
- Name:
- OCIA domain containing 1
- Previous symbol:
- -
- Synonyms:
- FLJ20455, TPA018, OCIA, Asrij
- Chromosome:
- 4p11
- Locus Type:
- gene with protein product
- Date approved:
- 2004-09-15
- Date modifiied:
- 2018-02-12
Related products to: OCIAD1 Peptide
Related articles to: OCIAD1 Peptide
- The apoptotic pathway mediated by mitochondria depends on the activation of pro-apoptotic Bcl-2 proteins Bax and Bak. When they permeabilize the outer mitochondrial membrane (OMM), mitochondrial dysfunction occurs, leading to caspase activation. A recent study proposed that Bax accumulation on mitochondria increases apoptotic susceptibility, with adhesion-initiated signals regulating Bax. When adhesion signaling is inhibited, Bax translocates to the OMM, undergoes conformational change, and forms complexes that create pores. Although MOMP is well studied, mechanisms regulating Bax shuttling, non-canonical partners, and mitochondrial dynamics remain poorly understood. - Source: PubMed
Publication date: 2026/05/10
Tanisha Mehrin HaqueSiddique Md AymanAhmed ZubaierMustafa NashrahTasneem Fariha - Scanning genomes for selection signals could illuminate the impact of domestication, natural, and artificial selection on the phenotypic traits of cattle breeds. The present study investigated the diverse genomic selection signatures using whole genome sequencing data from 15 pooled samples of five indigenous cattle breeds of Tamil Nadu: Alambadi, Bargur, Kangayam, Pulikulam, and Umblachery. Two approaches, namely composite likelihood ratio (CLR) and fixation index (), were employed to detect selection signatures from the 1,390,449 filtered single-nucleotide polymorphisms. The analysis identified 7250 and 806 genomic regions containing selective sweeps in 1238 and 101 candidate genes using CLR and methods, respectively. These regions were predominantly associated with production traits ( and ), coat colour ( and ), disease resistance ( and ), and adaptation to tropical climates ( and ). Particularly, six regions were shared across all the five cattle breeds, of which, five were intergenic regions and one had a candidate gene, , associated with susceptibility to bovine tuberculosis. A total of 12 candidate genes were common between CLR and methods, relating to production, disease resistance, and behavioural traits. NETWORK analysis revealed six candidate genes allied with calving ease ( and ), milk fat yield (), bovine respiratory disease susceptibility ( and ), and meat and carcass traits (). This study presents the first genomewide map of selective sweeps in Tamil Nadu cattle breeds, providing insights into selection signatures and candidate genes that could enhance genomeassisted breeding for improved production and health. - Source: PubMed
Vani SBalasubramanyam DSingh KaranbirKarthickeyan S M KTirumurugan K GGopinathan AHepsibha PMadhuri B Jaya - Diabetic kidney disease (DKD) is a multifactorial complication of diabetes involving mitochondrial dysfunction and immune cell infiltration. However, the causal relationships remain unclear. - Source: PubMed
Publication date: 2025/12/25
Zhang TianyueWu JunxiaZhang JiazhiHu YepengZhao YimingMao GuangyunJiao JingjingWang JunChen RiqiuZheng Chao - Hypertension (HTN) is a mitochondrial and metabolic disease. However, cause-effect connections between mitochondrial dysfunction and HTN remains uncharted. we focused on mitochondria-related genes, identifying potential causal-genes-relevant blood pressure (BP) using mitochondria-related genome-wide Mendelian randomization (MR). Through the summary statistics from cis-expression quantitative trait loci (cis-eQTL) datasets (human blood and artery), mitochondrial transcription factor A (TFAM), and genome-wide association studies (GWAS) datasets of BP indices (systolic blood pressure [SBP], diastolic blood pressure [DBP], pulse pressure [PP], and mean arterial pressure [MAP]) and HTN. we conducted a MR analysis to explore the potential causal relationship between mitochondrial-related genes and the BP indices, HTN. Sensitivity analysis and Bayesian colocalization were employed to validate this causal relationship. In aorta, HIBCH expression was negatively associated with SBP; OCIAD1 expression was positively associated with MAP. In tibial artery, HIBCH expression was negatively associated with SBP; OCIAD1 expression was positively associated with SBP, PP, and MAP; SLC25A37 was positively associated with MAP. In blood, LACTB expression was negatively associated with SBP, PP, and MAP; OCIAD1 expression was negatively associated with SBP and PP; and MTX1 expression was negatively associated with MAP. HARS2 expression was positively associated with SBP and PP; RAB24 and PRELID1 expression was positively associated with DBP; and NME6 expression was positively associated with SBP and DBP. In conclusion, the regulation of blood pressure correlates with mitochondria-related genes (HIBCH, SLC25A37 and OCIAD1 in artery; LACTB, OCIAD1, MTX1, HARS2, RAB24, PRELID1 and NME6 in blood). This study provides scientific evidence for specifically regulating BP phenotypes. - Source: PubMed
Publication date: 2025/11/14
Zhang HongruiLi XiaoyangLiu YichenLiang ZhuoshuaiLi RuofeiGao WenhuiWang BoZhang YuchenTian YuyangHu XinmengJin HuizhenQiu ShuangLi YongGu YuluLiu SiyuLiu YunkaiCheng YiShi JikangLiu Yawen - Arrhythmogenic cardiomyopathy (ACM) is a hereditary heart disease characterized by fibrofatty myocardial replacement and a predisposition to malignant ventricular arrhythmias. The underlying pathomechanisms remain incompletely understood, and specific disease markers are sparse. This study aimed to characterize the myocardial transcriptome and proteome in ACM patients and assess whether key identified molecules were also detectable in plasma and tissue samples. - Source: PubMed
Publication date: 2025/11/12
Akdis DenizWeidmann LukasNanni PaoloGaertner AnnaMilting HendrikBode PeterBrunckhorst CorinnaChen LiangTanner Felix CRuschitzka FrankSaguner Ardan MDuru Firat