PITX2 (Human) Recombinant Protein (P01)
- Known as:
- PITX2 (Human) Recombinant Protein (P01)
- Catalog number:
- H00005308-P01-25
- Product Quantity:
- 25 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- PITX2 (Human) Recombinant Protein (P01)
Related genes to: PITX2 (Human) Recombinant Protein (P01)
- Gene:
- BZW2 NIH gene
- Name:
- basic leucine zipper and W2 domains 2
- Previous symbol:
- -
- Synonyms:
- HSPC028, MST017, MSTP017
- Chromosome:
- 7p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-05
- Date modifiied:
- 2016-10-05
- Gene:
- C2CD3 NIH gene
- Name:
- C2 calcium dependent domain containing 3
- Previous symbol:
- -
- Synonyms:
- DKFZP586P0123
- Chromosome:
- 11q13.4
- Locus Type:
- gene with protein product
- Date approved:
- 2007-10-17
- Date modifiied:
- 2016-06-08
- Gene:
- MBTD1 NIH gene
- Name:
- mbt domain containing 1
- Previous symbol:
- -
- Synonyms:
- SA49P01, FLJ20055
- Chromosome:
- 17q21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-15
- Date modifiied:
- 2015-04-21
- Gene:
- PITX2 NIH gene
- Name:
- paired like homeodomain 2
- Previous symbol:
- IRID2, IHG2, RIEG, RIEG1, RGS
- Synonyms:
- IGDS, RS, Brx1, Otlx2, ARP1
- Chromosome:
- 4q25
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-05
- Date modifiied:
- 2016-01-27
- Gene:
- TMEM63C NIH gene
- Name:
- transmembrane protein 63C
- Previous symbol:
- C14orf171
- Synonyms:
- DKFZp434P0111, CSC1, hsCSC1
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-10
- Date modifiied:
- 2017-10-17
Related products to: PITX2 (Human) Recombinant Protein (P01)
Related articles to: PITX2 (Human) Recombinant Protein (P01)
- The salmon trout or rainbow trout (Oncorhynchus mykiss) is a teleost fish are characterized by the presence of lingual teeth. The objective of this study is to investigate their development, particularly in relation to the expression of genes associated with mammalian odontogenesis. Sixty fry were reared in a freshwater aquarium at 7°C. Specimens at developmental stages ranging from D0 (hatching) to D35 were collected and subjected to histological (Masson's trichrome) and immunohistochemical analysis, including the expression of proteins associated with the Pitx2, Shh, MSX1, Pax9, Bmp4 and β-catenin genes. The developmental patterns of the lingual teeth are similar to those of the maxillary and mandibular teeth. These are not giant papillae or pseudoteeth. The initiator gene Pitx2 is expressed in the epithelium during early stages but subsequently diminishes. Bmp4, Shh and β-Cat exhibit a pattern similar to that of mammals, except for the absence of the enamel node. Surprisingly, however, we observe expression of Msx1 and Pax9 in the dental mesenchyme as well as in the epithelium, a phenomenon unknown in mammals. The second week marks an increase in the expression of these two proteins and of Shh, while Bmp4 does not appear in large quantities until 10 days. Incidentally, the mucous glands (cement glands) express Shh, Pitx2, Msx1, Pax9 and β-catenin. In conclusion, tongue teeth are 'classical' teeth; their gene expression patterns are similar to those in mammals, except that Msx1 and Pax9 are expressed in both epithelial and mesenchymal tissues in this species. - Source: PubMed
Louryan StéphaneDuterre MyriamVanmuylder Nathalie - Chromatin-based repression is essential for retinal development, yet the genome-wide binding landscape of Polycomb repressive complex 2 (PRC2) in the developing retina has not been defined. In particular, how the PRC2 catalytic subunit EZH2 associates with chromatin and relates to transcriptional control in retinal progenitor cells (RPCs) remains incompletely characterized. - Source: PubMed
Davis EmilyKhan AbdullahAldiri Issam - The modification of the male right tentacle (MRT) into a copulatory organ in Cipangopaludina chinensis represents a prominent sexual dimorphism, yet the molecular mechanisms underlying its development remain poorly understood. This study observed the distinctive histological morphology of MRT, and then explored its potential genetic regulatory networks through transcriptomic analysis. Comparative transcriptome analysis across tentacles of different sexes and sides identified numerous differentially expressed genes (DEGs). Notably, the homeobox gene Pitx2, a central regulator of left-right asymmetric development in animals, was significantly upregulated in the MRT. Transcription factors involved in sexual development (e.g., Dmrta2, Sox10), genes related to hormone synthesis (Daf9, Cyp2j4), and the pro-apoptotic gene Bax were also specifically upregulated, while the apoptosis inhibitor gene Iap1 was downregulated. Weighted Gene Co-expression Network Analysis (WGCNA) further identified key modules highly correlated with the MRT phenotype, which were enriched for biological processes such as hormone response, cell morphogenesis, and apoptosis-related pathways. Our results suggest that the sexually dimorphic development of the tentacle in C. chinensis likely involves the coordinated action of a Pitx2-mediated left-right asymmetry pathway, sex-determination signals, and a local hormone-induced apoptotic remodeling program, revealing a complex regulatory mechanism underlying its morphological specialization. - Source: PubMed
Publication date: 2026/06/01
Wang GangChen SisiWang FangSun NiyingWei DongchengWang ZhiyongYang GendiPang AoboBian ZhijuanHou ShouquanFujaya YushintaTan KianannZhang DaizhenBian XunguangChen Lianfu - Crohn's disease (CD) is highly heterogeneous in presentation and progression with no cure. Molecular phenotyping has been used to elucidate cellular and tissue-based alterations to characterize drivers and effects of disease. One currently understudied class of functional molecules is long non-coding RNAs (lncRNAs). Studying the full lncRNA landscape in CD is challenging due in part to an incomplete lncRNA annotation and a lack of their functional characterization in tissues of interest. We used a genome-guided alignment strategy to assemble predicted lncRNA transcripts using short RNA-sequencing data from colon tissue of adult patient samples. When combining our predicted lncRNAs with previous lncRNA annotations, we determined 98 that were differentially expressed, recapitulating many from previous IBD studies while also uncovering new ones. We built gene co-expression networks to cluster lncRNAs with functionally characterized protein-coding genes. Clusters containing differential lncRNAs were correlated to disease status and associated with pathways related to the humoral immune response, metabolism, and tissue regeneration. We uncovered multiple differential lncRNAs whose expression significantly correlated with nearby differential protein-coding genes that have also been differentially expressed in other IBD datasets, such as PITX2. We focused on a predicted lncRNA that is antisense to the PITX2-adjacent lncRNA PANCR, which we called PANCR-AS1, and provide multiple lines of evidence that support PANCR-AS1 functioning as an enhancer of PITX2 expression. Overall, we determined lncRNAs that are potential contributors to CD pathogenesis. We developed a robust pipeline for identifying lncRNAs in diseased and non-diseased tissue that are absent from reference annotations. We also outlined a framework to pinpoint significant disease-associated lncRNAs with potential functional activity related to their nearby protein-coding genes. - Source: PubMed
Publication date: 2026/05/25
Kennedy Ng Meaghan MSilverstein SophieNishiyama Nina CBeasley CarolineLian GraceHuan BenjaminLau GwenWeaver DavidAwad AyeshSchaner Matthew RSheikh Shehzad ZFurey Terrence S - Post-stroke depression (PSD) affects approximately 30% of stroke survivors and worsens functional outcomes, yet its biological basis remains poorly understood. - Source: PubMed
Xu Zhi-JieZhang Su-XiangLi Ji-LingWu Jia-JiaMa JieMa Zhen-ZhenTao Ji-MingHua Xu-YunXu Jian-Guang