P2RX4 Peptide
- Known as:
- P2RX4 Peptide
- Catalog number:
- 42-753p
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Prosci
- Gene target:
- P2RX4 Peptide
Related genes to: P2RX4 Peptide
- Gene:
- P2RX4 NIH gene
- Name:
- purinergic receptor P2X 4
- Previous symbol:
- -
- Synonyms:
- P2X4
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1997-10-09
- Date modifiied:
- 2016-10-05
Related products to: P2RX4 Peptide
Related articles to: P2RX4 Peptide
- Purinergic P2X receptors () play key roles in neuroinflammatory processes through ATP-gated ion channel signaling. Dysregulation of receptor activity has been implicated in maternal immune activation, mitochondrial dysfunction, oxidative stress, and synaptic abnormalities associated with autism spectrum disorder (ASD). Despite increasing mechanistic evidence, the contribution of gene variants to ASD remains poorly understood. - Source: PubMed
Publication date: 2026/07/18
Ünsel-Bolat GülBolat Hilmi - Persistent upregulation of the purinergic receptor P2X4R is strongly associated with microglial activation in neuropathic pain, yet the epigenetic mechanisms linking chromatin remodeling to its dysregulation remain unclear. Here, we delineate a hierarchical epigenetic cascade that promotes transcriptional activation of P2X4R in spinal microglia following nerve injury. In a mouse spared nerve injury (SNI) model, microglial activation was accompanied by increased expression of P2X4R and the histone acetyltransferase p300, together with enhanced histone acetylation (H3K9ac, H3K27ac, H4K5ac, and H4K8ac) and increased chromatin accessibility at the P2rx4 promoter. Microglia-specific deletion of p300 blunted injury-induced histone acetylation and suppressed P2X4R upregulation. We further demonstrate that the acetylation reader BRD4 is recruited to these regions and cooperates with the transcription factor SP1 to drive P2rx4 transcription, supported by chromatin analyses revealing inducible assembly of a BRD4-p300-SP1 axis. Disruption of this cascade via p300 inhibition (C646) or BRD4 blockade (JQ1) attenuated spinal neuroinflammation and alleviated nociceptive hypersensitivity. Notably, reactivation of P2X4R by BzATP largely reversed the analgesic effects of BRD4 inhibition, establishing P2X4R as a critical downstream effector. Collectively, these findings support a p300-BRD4-SP1 epigenetic cascade linking chromatin remodeling to microglia-mediated neuropathic pain, highlighting this pathway as a potential therapeutic target. - Source: PubMed
Publication date: 2026/07/17
Wang DaojuanWang TingyuLi YinYu XinyeCai ShenquanWang ChunWang YihanZhu ZhengquanHuang YingWang YongCao WangsenTao Gaojian - Excessive production of reactive oxygen species during photodynamic therapy (PDT) can exacerbate inflammation at the infection site and increase the risk of tumor metastasis, thereby posing significant challenges to treatment efficacy. In this study, a chessboard-structured microneedle patch (HPC@PCN CMN) was designed using a micromolding technique. This design spatially separates and encapsulates photosensitizers and antioxidants within distinct fast- and sustained-release microneedle systems, respectively, thereby achieving spatiotemporally ordered control of PDT and anti-inflammatory treatment. Additionally, by adjusting the crosslinking degree of hyaluronic acid, the release rate of antioxidant drugs can be regulated, which facilitates a prolonged anti-inflammatory effect. The results indicate that the anti-inflammatory process of HPC@PCN CMN can alleviate inflammation by inhibiting the ATP-P2RX4 pathway, demonstrating promising efficacy in the treatment of acne and melanoma. Overall, the developed chessboard microneedle platform is programmable, enabling not only the sequential regulation of oxidation-antioxidation but also the potential for broader applications in drug-delivery scenarios. - Source: PubMed
Publication date: 2026/07/17
Jiang YechunGou YongqiShen HuiWang YidieZhang WeinanWu YayunLiu LitaoFang ShuHu MingWang WanniXu LinglingQian Haisheng - Pathological ventricular remodeling is an adverse tissue response following acute myocardial infarction (AMI), characterized by an exaggerated fibrosis leading to tissue disorganization and chronic heart failure. Cardiac fibroblasts have a prominent role in the healing process, but also in the fibrosis development, through their differentiation into myofibroblasts, which produce the extracellular matrix, in response to ischemia-reperfusion. Recently, the ATP-gated P2X4 ionotropic receptor has been identified as a key regulator of macro-autophagy, activated under metabolic challenges. - Source: PubMed
Publication date: 2026/07/10
Vinhais da Silva Ana ValeriaStrella JulietteChesseron SimonAupart ArthurHeraud-Meley AudreyMiquelestorena-Standley ElodieOhresser MarcCongiu LudovicaBoué-Grabot EricBourguignon ThierryRoger SébastienChadet StephanieIvanes Fabrice - Identifying disease-modifying drug targets is crucial for developing effective Alzheimer's disease (AD) treatments. - Source: PubMed
Publication date: 2026/06/29
Yang YuxinXu JielinHou YuanZhou YadiSaykin Andrew JCheng Feixiong