GABRA5 (Human) Recombinant Protein (P02)
- Known as:
- GABRA5 (Human) Recombinant Protein (P02)
- Catalog number:
- H00002558-P02-25
- Product Quantity:
- 25 ug
- Category:
- -
- Supplier:
- Abno
- Gene target:
- GABRA5 (Human) Recombinant Protein (P02)
Related genes to: GABRA5 (Human) Recombinant Protein (P02)
- Gene:
- GABRA5 NIH gene
- Name:
- gamma-aminobutyric acid type A receptor alpha5 subunit
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 15q12
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-07
- Date modifiied:
- 2016-02-04
- Gene:
- HMCN2 NIH gene
- Name:
- hemicentin 2
- Previous symbol:
- -
- Synonyms:
- DKFZp434P0216, FLJ23816
- Chromosome:
- 9q34.11
- Locus Type:
- gene with protein product
- Date approved:
- 2005-06-03
- Date modifiied:
- 2018-11-16
- Gene:
- KCTD10 NIH gene
- Name:
- potassium channel tetramerization domain containing 10
- Previous symbol:
- -
- Synonyms:
- MSTP028, BTBD28
- Chromosome:
- 12q24.11
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-28
- Date modifiied:
- 2019-02-21
- Gene:
- RGPD4 NIH gene
- Name:
- RANBP2 like and GRIP domain containing 4
- Previous symbol:
- -
- Synonyms:
- RGP4, DKFZp686P0288
- Chromosome:
- 2q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-12-15
- Date modifiied:
- 2019-02-18
- Gene:
- WIPI2 NIH gene
- Name:
- WD repeat domain, phosphoinositide interacting 2
- Previous symbol:
- -
- Synonyms:
- ATG21, CGI-50, FLJ12979, FLJ14217, FLJ42984, DKFZP434J154, DKFZp686P02188, ATG18B
- Chromosome:
- 7p22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-15
- Date modifiied:
- 2016-03-01
Related products to: GABRA5 (Human) Recombinant Protein (P02)
Related articles to: GABRA5 (Human) Recombinant Protein (P02)
- Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), characterized by persistent pain, is significantly associated with sexual dysfunction, yet the underlying mechanisms remain poorly understood. - Source: PubMed
Luan JiaochenGu QiYu MengchiChen DanniXu ChunluZhang JiayiYang JieSong Ninghong - This study aimed to identify genetic markers for body weight in adult male Dongfeng sika deer (Cervus nippon) using a genome-wide association study (GWAS). A cohort of 266 healthy, five-year-old stags was phenotyped and genotyped via whole-genome resequencing. Population structure was assessed, and a mixed linear model (MLM) was employed for association testing, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses of candidate genes. The GWAS identified twelve genome-wide significant SNP loci, which were annotated to seven candidate genes: ERC2, LOC122708028, FHIT, CASP14, UBE3A, NRXN3, and GABRA5. Functional enrichment analyses revealed these genes are significantly involved in the γ-aminobutyric acid (GABA)ergic synaptic transmission pathway and pathways related to DNA damage repair and cell cycle regulation. This study provides insights into the genetic mechanisms underlying body weight traits in adult male Dongfeng sika deer and offers a reference for subsequent functional exploration of candidate genes. - Source: PubMed
Publication date: 2026/06/11
Zhang XinyuanZhang YanZhao LiepingZhao YaoQian Wen-XiGai GuanghuiSong JunDu PeizeHan HuanshengZhang Zhen - To investigate the association between polymorphisms in the , , and genes and growth traits in Dongfeng sika deer and to identify potential molecular markers for breeding, this study was conducted based on prior genome-wide association analysis. Based on the previous GWAS analysis of 266 Dongfeng sika deer, the SNP loci of , , and genes were detected in 36 male deer samples. The genetic parameters were calculated, and an association analysis with growth traits was carried out. Phenotypic analysis indicated that body weight and chest circumference had higher coefficients of variation than other growth traits, and body weight showed a strong positive correlation with body-slant length (r = 0.743, < 0.01) and a moderate correlation with chest circumference (r = 0.709). A total of six SNP loci were identified, including three within (Chr13-8442730, Chr13-9033380, and Chr13-9045819), one within (Chr14-5681678), and two within (Chr20-66603370 and Chr20-66618510). The dominant genotypes at these loci include CG (CC), AA, CG, CC (CG), AA, and GG (GC). Linkage disequilibrium analysis revealed a relatively strong association between Chr13-8442730 and Chr13-903380 on chromosome 13. Combined genotype analysis showed that diplotype CCCGGC was associated with higher body weight and larger chest circumference than other genotype combinations. Gene expression analysis showed that the relative expression levels of , , and were lower in the low-growth group than in the high-growth group, and expression variation was also observed within groups. Overall, gene expression levels appeared to be positively associated with growth traits, with higher expression associated with improved growth performance. These findings suggest that and may serve as candidate genes for further investigation and that the identified SNP loci may contribute to the development of molecular markers for the selection of growth traits in Dongfeng sika deer. The results provide a preliminary basis for molecular breeding and genetic improvement strategies in Dongfeng sika deer bucks and serve as an important reference for genetic improvement of growth traits in Cervidae. - Source: PubMed
Publication date: 2026/06/03
Zhang YanZhang XinyuanHan HuanshengWang Xue - Dynamic modulation of α5-GABAAR expression and synaptic distribution plays a pivotal role in neuronal homeostatic plasticity, critically influencing memory processes. This study aims to investigate the spatiotemporal dynamics of α5-GABAAR in hippocampal subregions (CA1, CA3, and DG) and their behavioral correlation in mice following sevoflurane exposure across eight timepoints. - Source: PubMed
Wang SixuanChen LuWang ShengranZhang ChenZhang MengxueWang ZhunDong JinpengLiu QiangweiDong ZhonglanWang XiaokunDong YingLuo YuanWang YonganYin Yiqing - Long-lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation. The objective of our study was to determine whether modulation of α5-GABA receptors by the α5-positive allosteric modulator (α5-PAM), MP-III-022, would improve cognitive deficits after surgery. - Source: PubMed
Publication date: 2026/05/12
Lyu JinruiNagarajan RajasekarSharmin DisharyMondal PrithuKambali MalteshWang MuxiaoZhou JinyanInoue MakotoCook James MRudolph Uwe