SCINTILLATION VIALS 6ML (2,500) CLICK
- Known as:
- SCINTILLATION VIALS 6ML (2,500) CLICK
- Catalog number:
- svc-06-sc-case
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- National diagnostics
- Gene target:
- SCINTILLATION VIALS 6ML (2 500) CLICK
Related genes to: SCINTILLATION VIALS 6ML (2,500) CLICK
- Gene:
- CAMK1G NIH gene
- Name:
- calcium/calmodulin dependent protein kinase IG
- Previous symbol:
- -
- Synonyms:
- VWS1, CLICKIII, dJ272L16.1
- Chromosome:
- 1q32.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-21
- Date modifiied:
- 2016-02-03
- Gene:
- CCL1 NIH gene
- Name:
- C-C motif chemokine ligand 1
- Previous symbol:
- SCYA1
- Synonyms:
- I-309, TCA3, P500, SISe
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1990-07-05
- Date modifiied:
- 2016-10-05
- Gene:
- CLMN NIH gene
- Name:
- calmin
- Previous symbol:
- -
- Synonyms:
- FLJ12383, KIAA1188, KIAA0500
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-12-09
- Date modifiied:
- 2016-07-05
- Gene:
- CTAGE7P NIH gene
- Name:
- CTAGE family member 7, pseudogene
- Previous symbol:
- CTAGEP, CTAGE7
- Synonyms:
- bA500G10.2, MGC33437, rcCTAGE5
- Chromosome:
- 10q26.3
- Locus Type:
- pseudogene
- Date approved:
- 2004-05-27
- Date modifiied:
- 2015-11-18
- Gene:
- DDIT4 NIH gene
- Name:
- DNA damage inducible transcript 4
- Previous symbol:
- -
- Synonyms:
- RTP801, FLJ20500, REDD-1, REDD1, Dig2
- Chromosome:
- 10q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-12
- Date modifiied:
- 2015-11-16
Related products to: SCINTILLATION VIALS 6ML (2,500) CLICK
Related articles to: SCINTILLATION VIALS 6ML (2,500) CLICK
- Osteosarcoma (OS), the most prevalent primary bone malignancy in adolescents, is characterized by aggressive progression and early metastasis. However, the epigenetic drivers of its metastatic heterogeneity remain poorly understood. Herein, we integrated bulk DNA methylation profiling and single-cell RNA sequencing (scRNA-seq) to elucidate the epigenetic mechanisms driving OS metastatic heterogeneity. Consensus clustering identified two methylation subtypes (K = 2) with distinct survival outcomes, where hypermethylated (MSO-high) tumors exhibited poor prognosis. Weighted gene co-expression network analysis (WGCNA) revealed methylation-associated modules enriched in metabolic and immune pathways, pinpointing key genes such as CAMK1G and SLC11A1. Single-cell profiling uncovered MSO-high myeloid cells associated with inflammatory and oxidative phosphorylation pathways, while MSO-high OS cells displayed transdifferentiation toward fibroblasts via pseudotime trajectories, remodeling the extracellular matrix (ECM) to facilitate lung metastasis. Conversely, MSO-low tumors activated HLA-B-mediated neutrophil-CD8+ T cell interactions, promoting lymphatic metastasis via CXCR4/CXCL12 signaling. Furthermore, functional validation using the DNA demethylating agent decitabine demonstrated reduced fibroblastic transdifferentiation and suppressed invasive capacity in MSO-high osteosarcoma cells, supporting the therapeutic potential of targeting methylation dysregulation. These findings establish a model where DNA methylation dictates metastatic phenotypes through differential tumor-stromal crosstalk, providing novel targets for epigenetic therapy to disrupt fibrotic-immune networks and metastatic colonization. - Source: PubMed
Publication date: 2025/09/05
Gao MenglongCui WeirongDuan HongliangGuo Jingjing - Statins, widely used for hypercholesterolemia, have shown anticancer properties including induction of apoptosis and ferroptosis, modulation of autophagy, and reprogramming of the tumor microenvironment, making them potential candidates for repurposing in cancer therapy. Although growing evidence suggests that statins may influence kinase signaling, current data remain inconclusive. To better understand this potential mechanism, we investigated the impact of statins on kinase activity. - Source: PubMed
Publication date: 2025/08/04
Lagunas-Rangel Francisco AlejandroJonsson JörgenJackevica LudmilaFredriksson RobertDambrova MaijaSchiöth Helgi B - Osteosarcoma is the most common primary bone cancer with a high propensity for local invasion and metastasis. An increasing number of research studies show that telomeres play an important role in the occurrence and development of cancer. Thus, we established a telomere-related signature in osteosarcoma to comprehensively evaluate the pathogenic roles of telomeres in this disease. - Source: PubMed
Publication date: 2025/01/27
Li ShihaoZhang LinaZhang Haiyang - Due to the diverse climate in Iran, there has been an opportunity for the emergence of different domestic sheep breeds. On the other hand, two of the seven wild sheep species have settled in the broad areas of Iran. This study investigated the introgression between wild and domestic Iranian sheep using the whole genome sequencing data for 55 domestic and 19 wild sheep. The study reveals introgression signals from Asiatic mouflon and urial in Iranian domestic breeds. The results of Treemix unveiled the introgression from the common ancestor of Iranian domestic sheep to Asiatic mouflons, which sheds light on the dynamics of gene flow between domestic and wild sheep in Iran. There were 36 genomic regions (containing 26 protein coding genes) introgressed from both Asiatic mouflon and urial into the genome of their domestic relatives. In the genomic windows containing 19 of the mentioned genes, we observed a noticeable drop in the dxy value of the urial vs. domestic and Asiatic mouflon vs. domestic sheep. Also, a decrease in nucleotide diversity was observed in these regions for wild and domestic sheep, suggesting the occurrence of a selective sweep in the mentioned genomic regions. The study found important genes in these regions that are involved in fertility (TTC29, STPG2), spatial memory and learning (CAMK1G), taste perception (OTOP1), visual system (DYRK2) and olfactory (LOC101110674). The results demonstrate that most genes affected by introgression between wild and domestic sheep are related to survival, reproduction and adaptation. This information can enhance our understanding of the impact of wild species on domesticated livestocks, providing us with clearer insights for management, breeding, and conservation of these species. - Source: PubMed
Publication date: 2025/01/07
Khalkhali-Evrigh RezaHedayat NematSeyedsharifi RezaShakouri MirdarioushPonnampalam Eric N - Adipose tissue is critical to the growth, development, and physiological health of animals. Reference genes play an essential role in normalizing the expression of mRNAs. Tissue-specific genes are preferred for their function and expression in specific tissues or cell types. Identification of these genes contributes to understanding the tissue-gene relationship and the etiology and discovery of new tissue-specific targets. Therefore, reference genes and tissue-specific genes in the adipose tissue of were identified to explore their function under exogenous starvation (1 d, 2 w, 6 w) and hypothermic stress (18 °C and 10 °C for 2 d and 8 d) in this study. Results suggest that 60SRP was the most stable reference gene in adipose tissue. Meanwhile, eight genes were validated as tissue-specific candidates from the high-throughput sequencing database, while seven of them (ADM2, βGP1, CAMK1G, CIDE3, FAM213A, HSL, KRT222, and NCEH1) were confirmed in adipose tissue. Additionally, these seven tissue-specific genes were active in response to starvation and hypothermic stress in a time- or temperature-dependent manner. These results demonstrate that adipose-specific genes can be identified using stable internal reference genes, thereby identifying specific important functions under starvation and hypothermic stress, which provides tissue-specific targets for adipose regulation in . - Source: PubMed
Publication date: 2023/05/06
Xue MiaomiaoWen HaiboXu PaoChen JianxiangWang QingyongTang YongkaiMa XueyanLv GuohuaLi HongxiaSong Changyou