5X PROTEIN LOADING BUFFER (10X1ML)
- Known as:
- 5X PROTEIN LOADING BUFFER (10X1ML)
- Catalog number:
- ec-887-kit
- Product Quantity:
- EUR
- Category:
- -
- Supplier:
- National diagnostics
- Gene target:
- 5X PROTEIN LOADING BUFFER (10X1ML)
Related genes to: 5X PROTEIN LOADING BUFFER (10X1ML)
- Gene:
- TYRP1 NIH gene
- Name:
- tyrosinase related protein 1
- Previous symbol:
- TYRP, CAS2
- Synonyms:
- GP75, CATB, TRP, b-PROTEIN, OCA3
- Chromosome:
- 9p23
- Locus Type:
- gene with protein product
- Date approved:
- 1991-09-04
- Date modifiied:
- 2016-04-19
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- To explore and characterize gene expression patterns and RNA-seq-derived sequence variation in samples from Chilean patients with low-grade oral epithelial dysplasia (LG-OED) and oral squamous cell carcinoma (OSCC). - Source: PubMed
Publication date: 2026/07/29
Dutra Mateus JoséCortes Patricio MirandaDíaz Valentina Fernanda FernándezVenegas Mauricio Alejandro SáezMorales-Pison SebastiánGonzález-Arriagada Wilfredo AlejandroFernández-Ramires RicardoAdorno-Farias Daniela - MicroRNAs regulate gene expression post-transcriptionally, yet target prediction faces a credibility gap: published methods drop sharply against CLIP-seq-validated negatives. We present DeepExoMir, a deep learning framework integrating frozen RiNALMo RNA language model embeddings with biologically informed features. Under a dual-probe ablation protocol on three miRBench test sets, DeepExoMir reaches mean AU-PRC 0.855, surpassing eight retrained baselines (paired bootstrap p<0.001). Evolutionary conservation and duplex structure prove largely redundant with language-model priors, motivating a structure-free Lite variant (0.863). On nine exosomal miRNAs from a companion melanogenesis study, DeepExoMir recovers literature-validated targets and ranks canonical pigmentation regulators (KITLG, MITF, TYRP1) in the top 5%. - Source: PubMed
Publication date: 2026/07/10
Lin Wen-HsienHsiung Chia-NiLien Wen-YuSieber Martin - Prolificacy and coat color are key economic traits influencing sheep production. This study evaluated a reduced panel of 48 SNPs previously associated with these traits and assessed its applicability to locally adapted Brazilian sheep breeds. A total of 1152 samples from 15 breeds, conserved in situ at conservation nuclei and ex situ in the Brazilian Animal Germplasm Bank, were genotyped. Allelic, genotypic, and haplotypic frequencies were estimated to compare genetic variability between in situ and ex situ populations. Additionally, linkage disequilibrium (LD) among SNPs within , a key gene associated with prolificacy, was evaluated across local breeds, revealing strong LD among specific markers. The results highlight the importance of the FecG () variant for prolificacy in hair sheep, confirming the presence of mutant allele E in prolific breeds, such as Santa Inês and Morada Nova, and identifying, for the first time, a high frequency of such allele in the Brazilian Blackbelly, which provides new insights into the genetic basis of this prolific hair breed. Other prolificacy-related genes, and , appear to have no functional role in locally adapted breeds, as initially hypothesized, considering genetic differences among European and tropical sheep. Allelic and genotypic variation in , , , and genes reflected differences between wool and hair sheep and between local and commercial breeds. Overall, the results indicate that the germplasm bank effectively preserves in situ diversity. In conclusion, the reduced SNP panel efficiently genotyped Brazilian sheep for prolificacy and coat color SNPs, confirming which markers are present and segregating in these breeds. However, its utility could be improved by removing markers of limited relevance in the targeted breeds. - Source: PubMed
Publication date: 2026/07/01
Rodrigues Camila SouzaFaria Danielle Assis deAzevedo Hymerson CostaSilva Kleibe de MoraesFacó OlivardoSantos Sandra AparecidaBraga Ramayana MenezesCaetano Alexandre RodriguesMoraes José Carlos FerrugemSouza Carlos José Hoff dePaiva Samuel RezendeMcManus Concepta - Junken meat sheep exhibit a characteristic postnatal coat-color transition, in which the initially black fleece gradually fades and develops into a white-trunk phenotype; however, the transcriptional basis of this developmental change in follicular pigment output remains unclear. In this study, three Junken meat sheep lambs showing a natural postnatal black-to-white coat-color transition were sampled longitudinally at the newborn black-fleece stage and the 179-day white-trunk stage, generating three matched biological pairs for RNA-seq analysis. Representative candidate genes were further validated by RT-qPCR. Differential expression analysis identified 1657, 400, and 1086 differentially expressed genes in the C11 vs. C1, C22 vs. C2, and C33 vs. C3 comparisons, respectively. Functional enrichment analysis indicated that these genes were mainly associated with tyrosine metabolism, ECM-receptor interaction, focal adhesion, Phosphoinositide 3-kinase-Akt signaling pathway (PI3K-Akt), arachidonic acid metabolism, estrogen signaling, and immune-related pathways. Integrated analysis of shared downregulated genes and expression patterns highlighted candidate genes related to pigmentation, the ECM/follicular microenvironment, and regulatory or metabolic processes. Pigmentation-related genes, including , , , , and , were generally downregulated in 179-day white-trunk-stage skin, while changes in ECM- and metabolism-related genes suggested altered follicular microenvironmental regulation. These findings identify candidate transcriptional features associated with developmental coat-color fading in Junken meat sheep and support a follicular microenvironment-melanogenesis expression axis as a transcriptome-based framework for further investigation. - Source: PubMed
Publication date: 2026/06/30
Xi BinpengZhao SanchuanYu QianZhou HuaqianZhang WenzheChen YanCheng RuiqiWang ZhipengYang HuaLiu Jianbin - Fungal metabolites serve as a prolific source of structurally diverse bioactive compounds with significant potential for skin health and pigmentation regulation. In this study, two diastereomers of 11-hydroxycurvularin (compounds 1 and 2) and curvularin (compound 3) were isolated from and evaluated for their anti-melanogenic and immunomodulatory effects. The diastereomeric mixture of 11-hydroxycurvularins (HC mix) exhibited superior anti-melanogenic activity in α-MSH-stimulated B16F10 melanoma cells, surpassing the efficacy of the individual diastereomers, the parent compound 3, and the positive control arbutin, without inducing cytotoxicity. Mechanistically, the HC mix exerted dual regulatory effects by inhibiting tyrosinase enzymatic activity and downregulating the transcription of core melanogenic genes (Tyr, Tyrp1, and Tyrp2). Furthermore, the HC mix attenuated LPS-induced reactive oxygen species (ROS) production and selectively regulated inflammatory gene expression in RAW 264.7 macrophages and primary murine splenocytes, downregulating IL-1β and IL-6 while upregulating TGF-β. These findings highlight that hydroxyl substitution at C-11 is critical for enhancing biological potency. Collectively, the HC mix represents a potential candidate for managing pigmentary and inflammatory skin disorders, warranting further validation in human models. - Source: PubMed
Publication date: 2026/07/02
Seo Ja-HunKoo Hyun-SuMai Van-HieuKim Su-BinSeong Gi-HyeonNguyen Thuong T TSeon Jeong-EunChoi Ha-RimLee Hyang BurmOh Won-KeunKang Hyung-Sik