Human Interleukin 8,IL-8 ELISA KIT
- Known as:
- Human Interleukin 8,Interleukin-8 Enzyme-linked immunosorbent assay test KIT
- Catalog number:
- csb-e04641h
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Cusabio Elisa
- Gene target:
- Human Interleukin 8 IL-8 ELISA KIT
Related genes to: Human Interleukin 8,IL-8 ELISA KIT
- Gene:
- CXCL8 NIH gene
- Name:
- C-X-C motif chemokine ligand 8
- Previous symbol:
- IL8
- Synonyms:
- SCYB8, LUCT, LECT, MDNCF, TSG-1, IL-8, NAP-1, 3-10C, MONAP, AMCF-I, LYNAP, NAF, b-ENAP, GCP-1, K60, GCP1, NAP1
- Chromosome:
- 4q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2016-10-05
- Gene:
- CXCR1 NIH gene
- Name:
- C-X-C motif chemokine receptor 1
- Previous symbol:
- CMKAR1, IL8RA
- Synonyms:
- CKR-1, CDw128a, CD181
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-09
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2 NIH gene
- Name:
- C-X-C motif chemokine receptor 2
- Previous symbol:
- IL8RB
- Synonyms:
- CMKAR2, CD182
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-19
- Date modifiied:
- 2016-03-14
- Gene:
- CXCR2P1 NIH gene
- Name:
- C-X-C motif chemokine receptor 2 pseudogene 1
- Previous symbol:
- IL8RBP, CXCR2P
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- pseudogene
- Date approved:
- 1992-11-27
- Date modifiied:
- 2016-03-14
Related products to: Human Interleukin 8,IL-8 ELISA KIT
Related articles to: Human Interleukin 8,IL-8 ELISA KIT
- Myocardial injury in severe community-acquired pneumonia (SCAP) is often under-recognized, and interpretation of high-sensitivity cardiac troponin I (hs-cTnI) may be complicated by renal dysfunction and critical illness. We evaluated whether admission interleukin-8 (IL-8) and soluble suppression of tumorigenicity 2 (sST2) could support early risk stratification of guideline-consistent myocardial injury in patients with SCAP. - Source: PubMed
Publication date: 2026/07/30
Liu ShanshanLiu LuDong Jian - The complexity of pancreatic ductal adenocarcinoma (PDAC) progression, coupled with the lack of effective immunotherapy, underscores the imperative to deepen our understanding of its mechanisms and identify suitable immune-targeted interventions. The G protein alpha subunit 15 (GNA15) is significantly upregulated in PDAC and correlates with poor prognosis in patients with PDAC. Mechanistically, our study demonstrates that TET3 upregulates GNA15 expression through demethylation in PCs, and the highly expressed GNA15 activates the phosphorylation of STAT3 via the GP130-JAK signaling pathway, thereby promoting the expression and release of CXCL8. Subsequently, CXCL8 released by PCs binds to CXCR1 or CXCR2 in macrophages to promote M2 polarization. Additionally, high GNA15 expression was associated with Gemcitabine resistance, and the combination of Reparixin and Gemcitabine has shown favorable antitumor efficacy in PDAC. Collectively, we elucidated that GNA15 drives PDAC progression and M2 macrophage polarization via the STAT3-CXCL8 axis and established targeting GNA15-STAT3-CXCL8 as a novel strategy to improve PDAC therapies. - Source: PubMed
Publication date: 2026/07/30
Guo WeihuiQian ZhenyuanWang LeiXu WeilangWeng YuxinJiang KaiYe ZaiyuanXu JiSong Guangyuan - Breast cancer (BC) is a highly heterogeneous malignancy, and current treatments often suffer from toxicity, limited selectivity, and high cost. This study aimed to integrate transcriptome-level data, multi-layered network analysis, and drug repositioning strategies to identify candidate diagnostic and prognostic biomarkers for BC and propose potential repositioned drug candidates. - Source: PubMed
Publication date: 2026/07/24
Aydin BusraOkutan Beyza NurSara Fatmanur ElifGulseren GulcihanSinha Raghu - Lnk is an adaptor protein that attenuates cytokine receptor signaling in hematopoietic and immune cells, but its role in the behavior of CD8 T cells within solid tumors is not well defined. Using a murine melanoma model, we compared tumor growth and immune infiltration in Lnk-deficient mice and in wild-type controls and evaluated CD8 T cell trafficking toward chemokine signals produced by melanoma cells. Lnk-deficient mice developed smaller tumors containing greater numbers of intratumoral CD8 cytotoxic T cells. Tumor chemokine profiles, including high levels of interleukin-8 family signals such as CXCL2, were comparable between groups, yet CD8 T cells lacking Lnk showed enhanced migration toward melanoma-derived cues and accumulated more effectively within tumors . Pharmacologic inhibition of CXCR1/2 abolished this migratory advantage. Upon stimulation with interleukin-8 family chemokines, Lnk-deficient CD8 T cells exhibited increased activation of STAT3 and ERK signaling pathways. Moreover, antisense-mediated downregulation of Lnk in wild-type T cells resulted in enhanced accumulation within melanoma tumors following adoptive transfer into wild-type hosts. These findings identify Lnk as a negative regulator of CXCR1/2-dependent trafficking of CD8 T cells in melanoma and suggest that modulating this intracellular checkpoint may improve T cell trafficking into solid tumors and enhance the effectiveness of adoptive cellular immunotherapies. - Source: PubMed
Publication date: 2026/07/01
Derdikman Ofir YaelAswad MiranHayun MichalPechkovsky AntoninaKheshaiboun GhazalGhanayiem NarmeenKhier YasmineZohar YanivOfran YishaiLouria-Hayon Igal - Colorectal cancer (CRC) progression from benign polyps to malignant adenocarcinomas is a complex process involving the abnormal proliferation and differentiation of colon epithelial cells. Colorectal adenomas (CRAs), the precursors to most CRCs, are histologically classified into tubular adenomas (TAs), tubulovillous adenomas (TVAs), and villous adenomas (VAs). Despite new findings, the molecular signatures and pathways specific to each adenoma type remain poorly understood. This study aimed to identify specific biomarkers and pathways associated with the progression of TA, TVA, and VA to CRC. - Source: PubMed
Publication date: 2026/07/28
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