Monkey CD320 antigen(CD320) ELISA kit
- Known as:
- Monkey CD320 antigenic(CD320) Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- e09c1485
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Blue gene shanghai
- Gene target:
- Monkey CD320 antigen(CD320) ELISA kit
Related genes to: Monkey CD320 antigen(CD320) ELISA kit
- Gene:
- CD320 NIH gene
- Name:
- CD320 molecule
- Previous symbol:
- -
- Synonyms:
- 8D6, 8D6A
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-02-09
- Date modifiied:
- 2016-01-15
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- Disorders affecting the spinal cord (myelopathies) can cause severe disability. Despite diagnostic advances, approximately 12% to 18% of myelopathy cases continue to elude an etiological diagnosis, hampering effective treatment. - Source: PubMed
Publication date: 2026/08/17
Pluvinage John VAcero-Garces DavidGreco GiacomoMoseley Carson ESidhu SukhmanZorn Kelsey CKondapavulur SravaniMohan SonamNeely JohnMasciocchi StefanoBusinaro PietroSarreón Alexis GarcíaGifreu Fraixinó AriadnaMcCutcheon KristaCaspar ColetteDela Rosa RichardZamecnik ColinTubati AsrithaAsencor Andoni ITugizova MadinaChow FeliciaGalati AlexandraMina YairToro CamiloKang MinGuo Chu-YuehWesley Sarah FKvam KathrynLee SydneyAbdelhak AhmedMartin ThomasHuang Yun-HanBerman Sarah BLinnoila JennyEngstrom JohnMcCaddon AndrewGreen Ari JGreen RalphCree Bruce A CHauser Stephen LDeRisi Joseph LPleasure Samuel JGelfand Jeffrey MBravo Gary ÁlvarezGastaldi MatteoPardo Carlos AWilson Michael R Richie MeganDouglas VanjaShah MaulikGuterman Elan LNath AvindraSuen Catherine GLouine MartineauZuroff LeahGerdts JosiahKaralius MaryNylander AlyssaBevan CarolynLiu MaxDaghlas IyasSuleiman LeenaNguyen ToddMeyer BenjaminIbarra Karen - CD320, also known as the transcobalamin receptor, is a key receptor that mediates the cellular uptake of circulating vitamin B bound to transcobalamin. In humans, CD320 abnormalities cause metabolic and neurological disorders. Previous biochemical studies indicate that the CD320 is a monomeric receptor. In this study, we conducted molecular and cellular experiments in human embryonic kidney 293 cells to examine biosynthesis and molecular forms of human CD320. We found that CD320 was present on the cell surface in an oligomeric form, which consisted of five homomers interconnected via disulfide bonds, possibly in one or both low-density lipoprotein receptor (LDLR)-like domains. Deletion of the LDLR-like domains prevented CD320 oligomerization and cell surface localization, thereby impairing cellular uptake of vitamin B. By analyzing biochemical forms of CD320 in intracellular compartments, we showed that CD320 oligomerization occurred in the endoplasmic reticulum (ER) and that this process required the transmembrane domain but not N- or O-glycosylation of CD320. Moreover, we showed that the CD320 ΔE88 variant, identified in infants with abnormal vitamin B metabolism, did not prevent CD320 oligomerization but delayed CD320 trafficking out of the ER, resulting in low levels of CD320 oligomers on the cell surface. Together, our findings provide important insights into the biochemical nature and cellular mechanisms underlying the function of CD320 and associated pathologies in vitamin B metabolism. - Source: PubMed
Publication date: 2026/07/16
Guo WenjunQiu RenpingZhao XiaotongZhou TiantianLiu MengDong NingzhengWu Qingyu - Autoimmune diseases arise when B and T lymphocytes lose tolerance to self. Yet in most disorders, the underlying molecular determinants, including autoantibodies, epitopes and lymphocyte clones that drive tissue injury remain undefined. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation and autonomic dysregulation (ROHHAD) is a rare and often fatal pediatric neuroendocrine syndrome with strong evidence of antigen-driven paraneoplastic autoimmunity, including association with the intracellular autoantigen ZSCAN1. However, the effector immune circuit and the epitope-level determinants operating within the hypothalamus and brainstem have remained unknown. To address this challenge in ROHHAD and more broadly in autoimmune disease, we developed the Autoimmune Epitope and immunoGlobulin/Immune-receptor identification System (AEGIS), an integrated framework that links immune repertoires to their cognate self-epitopes. AEGIS combines B cell and T cell receptor profiling from sites of tissue injury with high-resolution epitope mapping, direct sequencing of antigen-specific autoantibodies, antibody-antigen folding, selection, and T cell antigen discovery. Applied to a deeply phenotyped child with ROHHAD, AEGIS revealed a compartmentalized, clonally restricted immune response in which brain-deposited IgG and expanded cerebrospinal fluid B cell and CD4 T cell clonotypes converged on shared ZSCAN1 epitopes, resolved to minimal determinants and peptide-MHC ligands. These findings provide a clone- and epitope-linked mechanistic map of ROHHAD autoimmunity and establish a generalizable framework for identifying candidate pathogenic clones and antigens across diverse autoimmune diseases. - Source: PubMed
Publication date: 2026/05/11
Bodansky AaronAhyong VidaDayao MonicaAsaki JamesVanasupa ShiLuDandekar RaviChen ShiniSabatino JoeKlauer SamKnudsen GiselleValenzuela Carlos LizamaMcCutcheon KristaZorn KelseySidhu SukhmanYu DavidGarcia SamanthaQuandt ZoeWang Chung-YuRojas Bryan CastilloTilton IrisCitron Y RoseSharathchandra AkshayGerungan ChloeTomko StuartRobbins Nathaniel MMcKeon AndrewCooper TiffanyHarms MeaganGomez RefujiaFancy Stephen P JGreen Ari JCaliskan IlayCadwell Cathryn ROstrem Bridget ElKaralius MaryBraun LindsayGupta SashaFrancisco CarlaPeng GretaReddy Alyssa TNash KendallPleasure Samuel JMandel-Brehm CaleighArnold Thomas D Anderson Mark SGerdts JosiahWilson Michael RDeRisi Joseph L - Pregestational obesity increases the risk of vitamin deficiencies in mothers, yet its impact on neonatal status and placental transporters is unclear. This study investigates the association between pregestational obesity and neonatal folate and vitamin B12 levels, as well as their biomarkers and the expression of placental transporters. This cross-sectional study included women with pregestational overweight or obesity (Body mass index [BMI]>25 kg/m²; Overweight/Obesity [Ob] group) and healthy weight (BMI<25 kg/m²; healthy weight [HW] group). In mothers and newborns, folate status was measured in plasma and red blood cells using liquid chromatography-tandem mass spectrometry to identify six chemical forms, and total vitamin B12 was quantified by electrochemiluminescence immunoassay, holotranscobalamin by chemiluminescent microparticle immunoassay, methylmalonic acid by liquid chromatography-tandem mass spectrometry, and total homocysteine by high-performance liquid chromatography with fluorescence detector in plasma. Placental folate receptor alpha (FOLR1) and transcobalamin receptor (TCblR/CD320) were determind using RT-qPCR reaction and Western blot. A P value <.05 was considered statistically significant. Women in the Ob-group had lower red blood cell folate status than those in the HW-group. Newborns of Ob-groups had decreased folate forms, total vitamin B12, holotranscobalamin, and higher methylmalonic acid. Female newborns of the Ob-group exhibites greater folate and vitamin B12 depletion than females in the HW. Placental expression of FOLR1 (protein) and TCblR/CD320 (mRNA) was lower in the Ob-group. Conversely, FOLR1 and TCblR/CD320 (mRNA and protein) were higher in female compared to male placentas (P<.05). Maternal obesity is associated with decreased neonatal folate and vitamin B12 levels, as confirmed by functional biomarkers. Altered placental FOLR1 and CD320 expression suggests impaired vitamin transport in obesity. The sex-specific differences may indicate an adaptive response in the female placenta, but further studies of mechanisms are warranted. - Source: PubMed
Publication date: 2026/05/05
Castaño-Moreno ErikaCarrasco-Negue KarinaDíaz de la Garza RocíoTreviño VíctorYajnik Chittaranjan SLamers YvonneGarmendia María LRonco Ana MCasanello Paola - Glioblastoma multiforme (GBM) remains a lethal brain tumor characterized by poor response to chemotherapy and limited blood-brain barrier (BBB) permeability. Nitrosylcobalamin (NO-Cbl), a nitric oxide (NO)-releasing cobalamin analog, was developed to selectively deliver cytotoxic NO to tumors through the transcobalamin II receptor (CD320). - Source: PubMed
Publication date: 2026/04/02
Bauer Joseph ASysel Annette MDunphy Michael J