Monkey apelin 36(AP36) ELISA kit
- Known as:
- Monkey apelin 36(AP36) Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- e09a1567
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Blue gene shanghai
- Gene target:
- Monkey apelin 36(AP36) ELISA kit
Related genes to: Monkey apelin 36(AP36) ELISA kit
- Gene:
- APLN NIH gene
- Name:
- apelin
- Previous symbol:
- -
- Synonyms:
- apelin, XNPEP2
- Chromosome:
- Xq26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-01
- Date modifiied:
- 2016-10-05
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- Apelin is a secreted peptide hormone involved in vasodilation, fluid homeostasis, and angiogenesis, and is therefore considered an important regulator of cardiovascular physiology. The APLN T-1860C (rs56204867) polymorphism is a genetic variation in the promoter region of the apelin gene (APLN) that is associated with increased susceptibility to cardiovascular risk factors. This study aimed to elucidate the relationship between the apelin gene -1860T>C single-nucleotide polymorphism, plasma apelin levels, and the risk of coronary artery disease (CAD) in a Syrian population. - Source: PubMed
Publication date: 2026/06/26
Abd-Alkareem Maisaa HassanShibli Hussam Eddin MohammedAlquobaili Faizeh Ali - Exerkines are bioactive molecules released in response to physical exercise and are considered important mediators of systemic adaptations. While previous research has largely focused on the effects of exercise modalities, the role of exercise intensity in regulating exerkine responses remains unclear. This narrative review summarizes findings on the effects of different exercise intensities on nine circulating exerkines with sufficient available data in healthy populations, including irisin, follistatin-like 1, myostatin, fibroblast growth factor 21, follistatin, leptin, adiponectin, apelin and brain-derived neurotrophic factor, without systematically covering all known exercise-responsive molecules. Given the narrative design of this review, the findings should be interpreted as descriptive and hypothesis-generating rather than as definitive evidence of intensity-dependent effects. The included studies show that acute exercise is associated with changes in several exerkines, with some direct within-study comparisons reporting larger responses under higher-intensity exercise conditions, whereas others exhibit increases, decreases, or no measurable changes across intensities. In contrast, studies examining chronic exercise interventions report changes in some studies and no measurable differences in others. Overall, the current evidence in this review suggests that exercise intensity may influence exerkine responses under some conditions, particularly during acute exercise, although the available findings remain limited and inconsistent across studies. - Source: PubMed
Publication date: 2026/06/10
Zhao YanqiWang TutuZhang XinuanWang WangeFu YuLaher IsmailLi Shunchang - To investigate the effect of inhibiting miR-503 on myocardial infarction (MI) and clarify its upstream regulatory factors and downstream effector pathways to identify potential therapeutic targets for MI. - Source: PubMed
Li JinHe YijieBi FangfangChen JunxinFan ZhenyanZhang YuChen EnyuXiao HongwenWu YunTian HuaZhou Yuhong - In modern dairy systems, sustained milk production over the lifetime of a cow depends critically on maintaining reproductive efficiency across repeated lactation cycles. However, repeated lactation and advancing parity impose cumulative metabolic and inflammatory stress that often compromises fertility and shortens productive lifespan. Increasing evidence suggests that immune dysregulation contributes to parity-associated reproductive decline, raising the possibility that sustained milk production requires adaptive immune regulation. We hypothesized that cows achieving reproductive longevity exhibit parity-dependent immune remodeling that supports continued reproductive function and extended milk production. To test this hypothesis, we profiled blood transcriptomes from 131 Holstein cows spanning parities 1-9. Analysis of 17 422 expressed genes identified six distinct parity-associated expression trajectories, revealing coordinated transcriptomic remodeling with increasing reproductive history. Differential expression analysis identified 1 405 parity-associated genes enriched in immune- and stress-related pathways, including MAPK and Rap1 signaling. Weighted gene co-expression network analysis further identified immune-regulatory modules strongly correlated with parity and key reproductive indicators, suggesting a central role of immune adaptation in sustaining reproductive efficiency. Machine learning analysis of 256 genes in significantly enriched pathways with P-adjusted < 0.05 prioritized PDE4C, APLN, and CDH15 as potential key predictors of reproductive persistence. Integration with co-expression networks demonstrated that these genes may function as highly connected hub nodes within immune- and stress-responsive modules. Collectively, these results indicate that coordinated immune signaling networks are associated with reproductive persistence and thereby contribute to extended milk production in dairy cows. This study provides molecular insight into the immune mechanisms underlying productive longevity and identifies candidate biomarkers with potential applications in genomic selection and precision herd management. - Source: PubMed
An ZhenjiangJiang YingyingLi WenjieChen KunlinDing QiangHuang JinmingLi JianbinWang HuiliXia ShuwenLi HuixiaShen Yangyang - Infantile hemangioma (IH) is the most common benign vascular tumor in infancy, characterized by rapid proliferation followed by spontaneous involution. Despite propranolol being established as first-line therapy, the cellular basis of this biphasic behavior and the mechanisms underlying propranolol efficacy have remained incompletely understood. Single-cell RNA sequencing (scRNA-seq) has recently enabled high-resolution dissection of IH tissue composition, revealing a previously uncharacterized cellular heterogeneity that advances our understanding of both disease pathogenesis and drug action. Here we systematically review these advances. Within the vascular compartment, APLN-positive endothelial cells with tip cell characteristics and CENPF-positive proliferative pericytes are identified as IH-specific subpopulations enriched in the proliferating phase and suppressed by propranolol treatment. CD146-positive mural cells, which constitute the predominant cell population in IH, exhibit a dynamic proangiogenic-to-adipogenic transition that may underlie the spontaneous proliferation-to-involution switch. Beyond vascular cells, macrophages, mast cells, and telocytes within the stromal microenvironment contribute to lesion progression and modulate drug response. These findings support a model in which IH progression is governed by dynamic shifts in dominant cellular subpopulations rather than endothelial hyperproliferation alone, and suggest how propranolol may act across multiple cell types. These insights may inform efforts to predict treatment response, assess rebound risk, and refine therapeutic strategies for IH. - Source: PubMed
Publication date: 2026/05/13
Chen MengLiu JunMeng JiaxinChen Qiang