Canine acylated ghrelin (AG) ELISA kit
- Known as:
- Canine acylated ghrelin (AG) Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- e08a1308
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Blue gene shanghai
- Gene target:
- Canine acylated ghrelin () ELISA kit
Ask about this productRelated genes to: Canine acylated ghrelin (AG) ELISA kit
- Gene:
- GHRL NIH gene
- Name:
- ghrelin and obestatin prepropeptide
- Previous symbol:
- -
- Synonyms:
- MTLRP, ghrelin, obestatin
- Chromosome:
- 3p25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2006-01-05
- Date modifiied:
- 2016-08-10
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- This study aims to investigate the influence of age and gender on the efficacy of metabolic surgery in patients with obesity with type 2 diabetes mellitus (T2DM). - Source: PubMed
Publication date: 2026/07/27
Ma BoDong YangfanLi TaoWang JunMa HuaShang Shaohua - This study evaluated the effects of live and heat-killed HP7 on intestinal motility, host physiological responses, and gut microbiota in a mouse model of delayed intestinal transit. BALB/c mice were treated with live HP7 (HP7L), heat-killed HP7 (HP7K), or bisacodyl following loperamide administration. HP7L and HP7K improved intestinal motility-related parameters, including fecal output, stool consistency, fecal moisture content, and charcoal meal transit. HP7 treatment also modulated circulating gastrointestinal hormones and inflammatory cytokines, with changes in serotonin, ghrelin, peptide YY, IL-6, and IL-17A. In intestinal tissues, HP7 regulated the expression of genes related to neuroendocrine signaling, water transport, mucus production, and tight junction integrity, including and . Histological analysis further showed reduced colonic tissue alterations and improved structural parameters. Microbiota analysis revealed that HP7L exerted broader effects on microbial community structure, whereas HP7K induced more selective taxonomic changes. Predicted functional profiling suggested that both HP7L and HP7K were associated with shifts in carbohydrate metabolism-related pathways, with HP7K showing additional predicted enrichment of pathways related to redox-associated metabolism, lipid metabolism, and microbial substrate utilization. These findings suggest that heat-killed HP7 retains biological activity and has potential as a postbiotic candidate for regulating intestinal motility. - Source: PubMed
Publication date: 2026/07/01
Gwon HyeonjunKim HyeonjiKim Joo-YunShim Jae-JungLee Jae-Hwan - Colorectal cancer (CRC) and non-Hodgkin lymphoma (NHL) are among the most prevalent cancer types globally by incidence and mortality. Both types are influenced differentially by chronic inflammation. Central to this inflammation are inflammatory genes that are meticulously regulated by nuclear factor kappa B (NF-κB) and tumor necrosis factor-α (TNF-α). NF-κB is negatively regulated by IκBα (encoded by ), while TNF-α's actions can be modulated by ghrelin (encoded by ). We investigated four single nucleotide polymorphisms (SNPs) in (rs4648068), (rs2233406), (rs1800629), and (rs1629816) as biomarkers for CRC and NHL risk in a cohort of Kuwaiti individuals. DNA samples from patients and controls were collected and genotyped for all SNPs, and their association with CRC or NHL risk was assessed. While rs4648068 showed a modest association with increased CRC risk, it had no significant impact on NHL risk. Conversely, rs2233406 increased NHL risk without affecting CRC risk. Interestingly, while rs1800629 showed a protective effect against NHL, it showed an increased risk for CRC. Finally, rs1629816 was associated with greater NHL but not CRC risk. Our findings suggests that variations of these inflammatory genes may be useful indicators for predicting cancer risk but might have unpredictable effects on cancer susceptibility, depending on the cancer type. - Source: PubMed
Publication date: 2026/05/23
AlSrayea SaraAlrashid Maryam HBastaki Nasmah KAl-Barrak Jasem - With the ongoing integration of offshore wind power and marine aquaculture, increasing attention has been paid to the potential biological effects of continuous low-frequency noise generated during wind farm operations on surrounding fish species. In this study, juvenile black scrapers (Thamnaconus modestus), a demersal species with low auditory sensitivity, were exposed to 500 Hz noise at low, medium, and high intensities (root-mean-square (RMS) sound pressure levels (SPLrms): 95 ± 5, 115 ± 5, and 135 ± 5 dB re 1 μPa) for 14 days to investigate physiological responses and molecular regulatory mechanisms. Low-intensity noise primarily suppressed the expression of feeding and digestion genes (Ghrl, Prss1) and activated oxidative stress and neuroprotective pathways. Medium-intensity noise caused dysregulation of lipid metabolism genes (Gba1, Degs2), significantly elevated malondialdehyde (MDA) content, and downregulated the expression of key genes in the neutrophil extracellular trap formation pathway (Ncf1, Ncf2, Ncf4). High-intensity noise disrupted the expression of circadian clock genes (Bmal1, Per2) and upregulated cholesterol synthesis pathway genes (Sqle, Cyp51a1, Dhcr24). Collectively, long-term low-frequency noise exposure during operation induced dose-dependent physiological stress on juvenile T. modestus, affecting digestive function, redox balance, lipid metabolism, immune responses, and circadian rhythm regulation. These findings contribute to understanding the potential impacts of low-frequency noise from offshore wind farms on marine fish and suggest that low-frequency noise should be incorporated as a key assessment criterion in the siting of marine ranching and fishery resource conservation. - Source: PubMed
Publication date: 2026/06/09
Song ShiqiShan Xiujuan - Reproductive efficiency in Nellore heifers is fundamental to the profitability and sustainability of beef production in tropical regions, where environmental stress can cause genotype-environment (G×E) interactions that affect fertility. Using 200,258 and 299,885 phenotypic records for heifer early pregnancy (HP) and heifer rebreeding (HR), respectively, we investigated the genetic basis of reproductive plasticity via single-step genomic reaction norms across a continuous environmental gradient (EG) defined from yearling weight records as a proxy for environmental quality. Genomic analyses included 22,556 animals (21,456 females and 1,100 sires) with genotypes imputed to 409,617 single-nucleotide polymorphisms (SNPs). We then performed genome-wide association analyses of the reaction norm intercept (genetic merit) and slope (environmental sensitivity), followed by multi-trait summary analyses and Bayesian fine-mapping of significant loci using imputed whole-genome sequence variants within ±100 kb windows around lead SNPs. - Source: PubMed
Publication date: 2026/06/08
Mota Lucio F MArikawa Leonardo MSantos Daniel J ABrito Luiz FFonseca Larissa F SOliveira Henrique NAlbuquerque Lucia G