Guinea pig Leukocyte elastase ELISA kit
- Known as:
- Guinea pig Leukocyte elastase Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- e05h0255
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Blue gene shanghai
- Gene target:
- Guinea pig Leukocyte elastase ELISA kit
Related genes to: Guinea pig Leukocyte elastase ELISA kit
- Gene:
- SERPINB1 NIH gene
- Name:
- serpin family B member 1
- Previous symbol:
- ELANH2
- Synonyms:
- EI, PI2, anti-elastase
- Chromosome:
- 6p25.2
- Locus Type:
- gene with protein product
- Date approved:
- 1993-07-27
- Date modifiied:
- 2016-04-06
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- Jalili syndrome (JS) is an autosomal recessive disorder with cone-rod dystrophy and amelogenesis imperfecta caused by CNNM4 variants. This study describes salivary proteome patterns observed in a small female JS cohort to characterize the oral molecular environment. - Source: PubMed
Publication date: 2026/03/24
Rattanapornsompong KhantiSriwattanapong KanokwanGavila PatcharapornRinkrathok MawikaSriwangyang KanokratJung Han SungPorntaveetus Thantrira - Immune dysregulation is central to the pathogenesis of sepsis, yet the underlying immunomodulatory mechanisms in pediatric sepsis remain insufficiently defined. This study aimed to elucidate key immune-related gene signatures and cellular features associated with pediatric sepsis. - Source: PubMed
Publication date: 2026/02/20
Shi JiaJiang JianzeYe JinDai Wei - Perivascular macrophages play a significant role in the pathogenesis of hypoxia-induced pulmonary hypertension via crosstalk to pulmonary artery smooth muscle cells (PASMCs) to stimulate their proliferation and pulmonary vascular remodeling. However, whether hypoxia exposure of macrophages affects cellular crosstalk remains entirely unclear. This study aimed to decipher the effects of hypoxia on macrophages' crosstalk to PASMCs and elucidate the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/01/07
Hao JiajinFang GuangyaoLi XiuchuanWang TingPeng KeLiu JinchengYang DachunKang XiaWang QiangYang YongjianLan Cong - Porcine deltacoronavirus (PDCoV) is an emerging porcine enteric coronavirus in China, with the risk of cross-species transmission and zoonotic infection. SERPINB1, serine protease inhibitor, is a potential therapeutic target. It is unclear whether its role in PDCoV replication. Our study found that PDCoV infection upregulates the expression level of SERPINB1, suggesting a potential role for SERPINB1 in the viral life cycle. Further investigation revealed that SERPINB1 is an essential factor for viral replication, and its RCL domain is the key region for its viral-promoting activity. Moreover, SERPINB1 interacts with accessory protein NS7a of PDCoV. Understanding the mechanism by which SERPINB1 targets viral encoded proteins to promote PDCoV replication can enrich the pathogenesis and immune mechanism of PDCoV, and provide new targets and important theoretical basis for the development of antiviral drugs. - Source: PubMed
Publication date: 2025/12/30
Yan JunfangLiu XinruZhu HuixinLi LiangPan HongyeBao RenjieLi QiutianSun JingSong HouhuiSu Mingjun - This study investigated the proteomic landscape of sound and carious coronal dentin to uncover the molecular signatures of host response, including tissue degradation, inflammation, and repair, across progressive stages of caries lesions. Dentin from deidentified human molars, grouped into 6 clusters of 3 teeth each, was pulverized to obtain ~1 g of tissue per cluster ( = 6). G1 and G2 protein extracts were obtained using guanidine before and after demineralization. Extracts from sound (S), distinct dentin caries (DDC), and extensive dentin caries (EDC) lesions were digested with trypsin and analyzed by label-free relative quantification via liquid chromatography-tandem mass spectrometry (LC-MS/MS). Spectral data were matched against the UniProt database using Mascot and Sequest HT in Proteome Discoverer. Statistical analysis using the package identified differentially expressed (DE) proteins (false discovery rate-adjusted < 0.05), and ingenuity pathway analysis revealed key pathways, regulators, and networks. A total of 320 proteins were identified, with differential expression observed in 80 for EDC × S, 16 for EDC × DDC, and only 3 for DDC × S. In the G2 × G1 comparison, 200 proteins exhibited differential recovery in at least 1 of the extracts. Proteins such as S100A8, S100A12, DEFA1, SERPINB1, MPO, and PRTN3 were upregulated in EDC compared with DDC and S. TIMP3, MMP20, DMP1, and other collagen and matrix-associated proteins showed higher coverage in G2 than in G1, revealing extract-specific profiles. Functional analysis highlighted enrichment in immune and inflammatory pathways, with strong activation of neutrophil degranulation, antimicrobial peptides, neutrophil extracellular trap signaling, and macrophage alternative activation in carious tissues. In conclusion, this study reveals stage-specific proteomic signatures in caries, reflecting a dynamic interplay between microbial-induced degradation and host-driven defense and repair. These findings offer new molecular insights into caries pathophysiology and may inform future diagnostic and therapeutic strategies. - Source: PubMed
Publication date: 2025/11/26
Vidal C M PRysavy OKulanthaivel SZeng ECavalcanti BCarrilho M RAraujo E M SCunha S R BDrake DXie X JBanas J