Guinea pig BET1 homolog(BET1) ELISA kit
- Known as:
- Guinea pig BET1 homolog(BET1) Enzyme-linked immunosorbent assay test reagent
- Catalog number:
- e05b0792
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Blue gene shanghai
- Gene target:
- Guinea pig BET1 homolog(BET1) ELISA kit
Related genes to: Guinea pig BET1 homolog(BET1) ELISA kit
- Gene:
- BET1 NIH gene
- Name:
- Bet1 golgi vesicular membrane trafficking protein
- Previous symbol:
- -
- Synonyms:
- hbet1
- Chromosome:
- 7q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-05
- Date modifiied:
- 2016-10-05
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- Aberrant lipid metabolism is a hallmark of hepatocellular carcinoma (HCC), yet the regulatory mechanisms governing lipid droplet (LD) dynamics and their contribution to tumor progression remain poorly understood. Here, we developed an ultrasensitive phosphoproteomic platform using high-affinity HPDA@Ti nanospheres to map LD-associated phosphorylation events across six HCC cell lines. By correlating phosphoproteomic signatures with LD morphology, we identified distinct regulatory signatures associated with LD size and abundance. Functional perturbation screens identified two distinct phosphoprotein modules controlling LD size: silencing , , , , and reduced LD size in Huh1 cells, whereas silencing , , , , , and enlarged LDs in Huh7 cells. Notably, we identified EPB41L3 as a critical metabolic-metastatic link; its loss decreased LD size and accelerated HCC migration and invasion, correlating with poor clinical prognosis. Crucially, we identified five key phosphorylation sites on EPB41L3 essential for its function; substituting these with alanine completely abolished its regulatory control over both LD size and HCC metastatic potential. Together, these findings delineate a phosphorylation-based regulatory network controlling the LD architecture and metastatic potential in HCC. Our study not only identifies potential therapeutic targets but also establishes a generalizable phosphoproteomic framework for interrogating lipid signaling in cancer metabolism. - Source: PubMed
Publication date: 2026/05/29
Mao Jian-WenXia YanLuo Xue-YangWang ShupeiGong JingyiXu JindianChen WeiweiWu JiaqiLi ZimengLuo JiahuiZhang HongyeLu QingWu DuojiaoWu Wei-ZhongWang JiaxiHuang Li-Hao - BET1 encodes a Golgi-associated membrane protein involved in vesicular transport from the endoplasmic reticulum (ER) to the Golgi apparatus. While the role of BET1 in cancer development remains poorly understood, its function in glioblastoma multiforme (GBM) has not been systematically investigated. In this study, we found that 15 out of 33 cancer types showed significant differential BET1 expression between tumor and normal tissues. Furthermore, survival analysis identified BET1 as an independent prognostic factor in GBM. Additional analyses revealed correlations between BET1 expression and the infiltration of immune cells, such as Tregs and CD4 + T cells, in GBM. Moreover, BET1 knockdown in glioblastoma cells reduced their proliferation and migration capacities. This study provides a comprehensive analysis of BET1, thereby advancing our understanding of its oncogenic potential in GBM. - Source: PubMed
Publication date: 2026/04/29
Li YuWu ChangmengXia YuhaoLin LiHe JuanXu LinlinXia YongJi Ling - Risperidone is a commonly used antipsychotic for treating psychiatric illness in children and adolescents. There is a large variability in risperidone response and discontinuation rates remain high. Pharmacogenomics offers the opportunity to improve risperidone outcomes, yet studies in pediatric populations are limited. We conducted a genome-wide association study (GWAS) to investigate genetic predictors of risperidone response in pediatric patients (n = 161) who received inpatient care at a pediatric hospital in a rural setting. Clinical, demographic, and treatment outcomes data, collected retrospectively, were incorporated into predictive models. While 41.0% of patients discontinued risperidone, patients remained on risperidone longer than other antipsychotics, with the exception of quetiapine. Female patients discontinued more quickly, as did patients in the acute program compared to residential. We identified nine genetic variants associated with risperidone outcomes: duration of risperidone treatment and frequency of risperidone discontinuation (rs10270303, intronic variant, PTPRN2), maximum risperidone dose (rs6014649, intergenic variant between CBLN4 and MC3R; rs56261530, synonymous variant, SHD), time to readmission (rs35722167, intergenic variant between UGT2A3 and UGT2B7; rs62382382, intronic variant, SGCD; rs62466698, intergenic variant between BET1 and GNG11; rs1152938, intronic variant, CPM), and duration of hospital stay (rs117426990, 3'-UTR variant, TMX3; rs5956073, intergenic variant between DOCK11 and LINC01285). Our study is the first GWAS of risperidone response in pediatric populations, which provides insights into the biological complexity of risperidone response, as well as moving toward precision antipsychotic treatment. Our study demonstrates the high value of conducting research in a community-based setting and highlights the need to expand research studies beyond academic medical centers. - Source: PubMed
Publication date: 2026/04/14
Staples Jack WKillam Shayna RBrown Karen EDalton RachelSather ElizabethChen QiangLoveland JoshuaSchwanke CorbinElias Abdallah FBigos Kristin LWoodahl Erica L - The filamentous fungus C1 has been developed into a highly productive protein production system for heterologous proteins like antibodies and vaccine candidates. While it is capable of secreting over 120 g/l of its native enzymes, monoclonal antibodies (mAbs) have been produced at titers exceeding 20 g/l, and strains engineered to produce human-type N-glycan structures have been developed. However, significant variability in mAb productivity and reduced production levels in glycoengineered strains limit the use of C1 as a widespread production host in the pharmaceutical industry. To address these issues, transcriptome analysis was conducted on strains producing five different mAbs with varying production efficiencies, as well as on mAb-producing strains with native and glycoengineered N-glycans. Genes related to protein folding and secretion, which are regulated in response to mAb production and glycoengineering, were over-expressed in a glycoengineered mAb producing C1 strain. In addition, genes identified based on previously described functions in the secretory pathway, including counterparts of human origin, were included in the study. - Source: PubMed
Publication date: 2026/04/02
Mäkinen MariAalto AnttiPakula TiinaWiebe Marilyn GHuuskonen AnneVitikainen MarikaValkonen MariHavukainen SamiEnglund EllinorKorja VeeraEmalfarb MarkValbuena Crespo NoeliaTchelet RonenSaloheimo Markku - The carapace of the Chinese soft-shelled turtle () is rich in collagen and stands as a crucial economic trait for assessing its quality, as well as a key indicator for selective breeding. However, current studies on the mechanisms underlying collagen deposition in the carapace remain severely limited, significantly hindering progress in selective breeding. Here, the gene of was molecularly characterized for the first time. Analysis of gene structure, phylogenetic tree, and amino acid sequence homology revealed that is relatively conserved among tetrapods but divergent from fishes. Collinearity analysis identified the BET1-COL1A2-CASD1-SGCE gene block shared across all 14 representative vertebrates and found that the is located on the Z chromosome of . Tissue expression analysis showed that was highly expressed in the heart, gonad, and lung. Additionally, expression levels markedly increased during carapace development, exhibiting a strongly positive correlation with the changes in collagen content of the carapace. In situ hybridization results revealed strong signal for the transcripts in fibroblasts of the dermal layer of carapace. Knockdown of the gene in the carapace cells of significantly reduced collagen content. Transcriptome analysis following knockdown identified several differentially expressed genes associated with collagen deposition, including , , and , as well as significantly enriched pathways such as the JAK-STAT signaling pathway, the apelin signaling pathway, and the Hippo signaling pathway. Our findings offer a molecular basis for elucidating the mechanisms of collagen deposition in the carapace of , while also supplying a potential target for the selective breeding of collagen-rich strains of . - Source: PubMed
Publication date: 2026/02/25
Zhu JunxianNing YingqiGao CaixiaChen ChenJi LiqinHong XiaoyouLiu XiaoliWei ChengqingZhu XinpingWang XuegengLi Wei