TNFSF13B Pre-design Chimera RNAi
- Known as:
- TNFSF13B Pre-design Chimera RNAi
- Catalog number:
- H00010673-R01
- Product Quantity:
- 20 nmol
- Category:
- -
- Supplier:
- Abno
- Gene target:
- TNFSF13B Pre-design Chimera RNAi
Related genes to: TNFSF13B Pre-design Chimera RNAi
- Gene:
- TNFSF13B NIH gene
- Name:
- TNF superfamily member 13b
- Previous symbol:
- TNFSF20
- Synonyms:
- BAFF, THANK, BLYS, TALL-1, TALL1, CD257
- Chromosome:
- 13q33.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-19
- Date modifiied:
- 2018-11-22
Related products to: TNFSF13B Pre-design Chimera RNAi
Related articles to: TNFSF13B Pre-design Chimera RNAi
- , which encodes B-cell-activating factor () and peptidylarginine deiminase 4 (), plays crucial roles in the pathogenesis of ANCA-associated vasculitis (AAV). This study investigated the associations of single-nucleotide polymorphisms (SNPs) in TNFSF13B/BAFF and genes with AAV susceptibility, clinical phenotypes, and disease activity in a Guangxi Chinese population. A case-control study included 324 AAV patients and 324 healthy controls. After propensity score matching (201 pairs), genomic DNA was genotyped for rs3759467 (formerly rs386492354) and rs1041569, and rs11203366 and rs874881 using multiplex PCR and high-throughput sequencing. Genetic associations were analyzed via logistic regression, subgroup, haplotype, and clinical correlation analyses. For each of the four SNPs separately, machine learning models (logistic regression, SVM, Random Forest, XGBoost) were built and evaluated via 5-fold cross-validation. No formal adjustment for multiple comparisons was applied due to the exploratory nature of this study. For , the rs3759467 C allele was protective (dominant model OR = 0.60, = 0.011; log-additive OR = 0.71, = 0.020; CA haplotype OR = 0.71, = 0.019), while the rs1041569 T allele was a risk factor (dominant model OR = 1.70, = 0.016). Subgroup analysis revealed stronger protective effects of rs3759467 in females, Han ethnicity, and MPA patients, and stronger risk effects of rs1041569 in Han ethnicity and MPA patients. Haplotype CA was protective (OR = 0.71, = 0.019), and TT was risk-associated (OR = 1.55, = 0.017). Both SNPs were associated with rash and hemoptysis incidence ( < 0.05). rs1041569 was also associated with RBC (red blood cell) count and HB (hemoglobin) levels ( < 0.05). For , rs11203366 and rs874881 showed no association with AAV susceptibility (all > 0.05). However, their genotypes were associated with disease activity (BVAS, Birmingham Vasculitis Activity Score), RBC count, and HB levels ( < 0.05). Although machine learning was applied to explore predictive patterns, its performance was suboptimal (AUC < 0.6), indicating limited clinical applicability. Accordingly, the primary findings rely on the genetic model analysis, and the machine learning results should not be overinterpreted as clinically actionable. SHAP analysis indicated that risk-associated genotypes contributed most to model predictions. gene polymorphisms rs3759467 and rs1041569 were associated with AAV susceptibility in this Guangxi cohort, influencing clinical manifestations like rash, hemoptysis, and anemia severity. polymorphisms rs11203366 and rs874881 are not associated with susceptibility but may correlate with disease activity and hematological parameters. These findings highlight the ethnic and clinical subtype specificity of genetic influences in AAV. Due to the lack of external validation, these findings are exploratory and require replication. - Source: PubMed
Publication date: 2026/06/20
Lu JiafuHuang SimeiWei ShuwenXue Chao - Accumulating evidence links dietary inflammatory potential to cancer, yet its association with lung cancer incidence and mortality remains inconsistent. This study aimed to examine the relationship between the Dietary Inflammatory Index (DII) and lung cancer risk, and to explore the underlying molecular mechanisms. - Source: PubMed
Publication date: 2026/06/21
Chen LingliFeng YiLiu MaolinAbulizi DilimulatiLiu SiqingGui DayingZheng XiangyuanZheng YafangWu JingxunWu XuanLiang WenhuaHou Xue - The bronchial epithelium acts not only as the primary physical barrier but also as an active sensor that responds to exogenous materials such as bacteria and viruses, by producing various cytokines including B-cell activating factor (BAFF). Although BAFF is a well-known protein in B-cell functions, its role in bronchial cell function remains undefined. Polyinosinic-polycytidylic acid (Poly (I:C)), a synthetic double-stranded RNA, serves as a model for viral infection that binds to toll-like receptor (TLR) 3 to trigger intracellular signal pathways. In this study, we investigated the effect of Poly (I:C)-induced BAFF expression on airway cell migration using Beas-2B human bronchial epithelial cells. Poly (I:C) increased BAFF expression and cell migration, along with the increased expression of N-cadherin, Vimentin and Slug (SNAI2), which are three primary markers for epithelial-mesenchymal transition (EMT). Cell migration was attenuated by small interfering RNA (siRNA) against BAFF, which also inhibited the expression of these EMT markers. Phosphorylation of c-Jun N-terminal kinase (JNK) was enhanced by Poly (I:C) and inhibited by SP600125, JNK inhibitor, leading to a decreased expression of BAFF and aforementioned EMT markers. Poly (I:C) increased reactive oxygen species (ROS), resulting in a ROS-dependent up-regulation of antioxidants (Catalase, superoxide dismutase (SOD)1 and heme oxygenase (HMOX)1) and Nrf2. Pre-treatment with N-acetylcysteine (NAC), ROS scavenger, inhibited Nrf2 activation and JNK phosphorylation. The increase in Nrf2 levels induced by Poly (I:C) was also attenuated by SP600125. Additionally, while NAC treatment inhibited BAFF expression, it caused little change in the expression of the three EMT markers. Increased BAFF expression was confirmed by Nrf2 binding to the BAFF promoter or an increase in the luciferase activity of BAFF promoter co-transfected with Nrf2 plasmids. Treatment with recombinant BAFF protein also increased cell migration and EMT marker expression. Taken together, our results demonstrate that Poly (I:C) promotes a regenerative migration of bronchial epithelial cells by inducing BAFF expression through the ROS-dependent JNK-Nrf2 signaling axis. - Source: PubMed
Publication date: 2026/05/11
Mani Yatham Naga SatyaYun Dae HeumMoon Eun-Yi - Clear cell renal cell carcinoma (ccRCC) exhibits extensive immune infiltration, yet the influence of immunological heterogeneity on clinical outcomes remains poorly elucidated. - Source: PubMed
Publication date: 2026/06/21
Chen YuanhongGuo ChunHuang ShaoangLing CaixiaLin WenxianLiang ZhengfangZhao JingjieMeng LingzhangTang YulianYe Kun - Despite medical advances, active tuberculosis (TB) remains difficult to diagnose, particularly in asymptomatic or paucibacillary cases lacking detectable pathogen evidence. Elevated oxidative stress is a hallmark of () infection, and the genes driving this process represent promising diagnostic biomarkers. Transcriptomic profiling captures dynamic host immune responses preceding clinical manifestations, while weighted gene co-expression network analysis (WGCNA) identifies functionally coherent gene modules. Integrating WGCNA with immune infiltration analysis, this study aimed to discover oxidative stress-related hub genes as robust biomarkers to address critical gaps in active TB detection and differential diagnosis. - Source: PubMed
Publication date: 2026/06/08
Shang XuetianJi XiuxiuDong JingYao SiyuZhang XinyueZhao YuehanJia HongyanHuang MailingWu YadongZhang LanyueZhu ChuanzhiZhang ZongdePan Liping