Bovine ITIH4 ELISA
- Known as:
- Bovine ITIH4 Enzyme-linked immunosorbent assay test
- Catalog number:
- kt-706
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Bovine ITIH4 ELISA
Related genes to: Bovine ITIH4 ELISA
- Gene:
- ITIH4 NIH gene
- Name:
- inter-alpha-trypsin inhibitor heavy chain 4
- Previous symbol:
- ITIHL1
- Synonyms:
- IHRP, H4P
- Chromosome:
- 3p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-30
- Date modifiied:
- 2019-03-08
Related products to: Bovine ITIH4 ELISA
Related articles to: Bovine ITIH4 ELISA
- Proteomics holds great promise for identifying potentially druggable effectors of common diseases, yet its application at population-scale across diverse ancestries, remains challenging. Here, we developed genetic imputation models for 2,594 plasma proteins using proteomic and genetic data from 54,219 UK Biobank participants, validating their performance across multiple ancestry groups and in an independent cohort. Plasma proteomes were then imputed for over 640,000 participants in the UK Biobank and the Research Program. To assess its aetiological value at population-scale, a further proteome-wide association study of cardiovascular diseases was performed across six genetic ancestries. We identified ∼9000 protein-disease associations across 89 cardiovascular conditions (PheCodes), the majority of which show consistent effects across ancestries and biobanks, with many comprising known targets of drugs either approved or under development. The associations reveal both shared and distinct proteomic signatures across cardiovascular conditions and defined clusters of distinct pathophysiology with shared underlying molecular pathways. Integration of data on tissue specificity and single-cell transcriptomics prioritised liver-derived proteins in circulation as candidate effectors of coronary artery disease, highlighting inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) as a putative effector. Using a liver-targeted CRISPR gene-editing platform, we show that disruption of ITIH4 reduces plasma cholesterol and pro-atherogenic lipid species in a preclinical model, consistent with a causal role in cardiovascular disease. Our study enables study of large-scale proteomics in diverse populations, provides a systematic map of protein associations of cardiovascular diseases, and demonstrates the utility of genetically imputed proteomes for target discovery and experimental validation. To facilitate proteomic analyses for the research community, the resultant models and association results have been made freely available through the OmicsPred platform. - Source: PubMed
Publication date: 2026/08/06
Xu YuLoesch DouglasTaylor Henry JKeating Michael FRitchie Scott CJiang XilinTran TamFoguet CarlesKhullar SaniyaYin JiayingPersyn ElodieManikpurage Hasanga DLiu YangBonglack EmmanuelaBen-Eghan ChiefGil LaurentPeng ZhongteHuang JianfengRoberts David JSun BenjaminRunz HeikoWood AngelaAngelantonio Emanuele DiWhelan Christopher DButterworth Adam SPetrovski SlavéDanesh JohnCollins Francis SNag AbhishekDrew Brian GDenny Joshua CPaul Dirk SLambert Samuel AInouye Michael - Alzheimer's disease (AD) pathogenesis involves widespread molecular alterations in both brain tissue and peripheral biofluids, yet the role of protein O-linked glycosylation in disease progression remains poorly characterized due to technical limitations in comprehensive O-glycoproteome profiling. - Source: PubMed
Publication date: 2026/06/26
Deng ZhenpengWang YanLiu LeiGuo XinZhu HaiyangDong MingmingGe YusongYu YongliangYe Mingliang - Tea consumption may be associated with skeletal muscle health, but longitudinal evidence based on repeated assessments remains limited. We examined the associations of tea intake and serum biomarkers with repeated skeletal muscle measures and explored whether these associations might be partly explained by multi-omics features. In this prospective cohort, 3408 adults were followed for approximately 12 years. Skeletal muscle mass was measured by dual-energy X-ray absorptiometry, handgrip strength by digital dynamometry, gut microbial taxonomic and functional profiles by shotgun metagenomic sequencing, serum proteins by data-independent acquisition mass spectrometry, and fecal metabolites by targeted UPLC-MS/MS metabolomics. Linear mixed-effects models examined longitudinal associations, and mediation analyses estimated indirect effects. In longitudinal analyses, higher tea consumption frequency was associated with greater appendicular skeletal muscle mass, appendicular skeletal muscle index, and handgrip strength (β: 0.037-0.140; 95% CI: 0.002-0.205). Higher circulating flavan-3-ols showed similar associations with these muscle-related outcomes (β: 0.085-0.174; 95% CI: 0.007-0.254), whereas no significant associations were observed with walking speed. Exploratory multi-omics analyses identified tea-related differences in gut microbial species and functional pathways, fecal metabolites, and circulating proteins, including Gemmiger formicilis, amino acid biosynthesis pathways, fructose 1,6-bisphosphate, VTN, CFI, CNDP1, and ITIH4. Exploratory mediation analyses identified statistical indirect associations involving multi-omics features, with estimated proportions mediated ranging from 4.5% to 19.0%. Overall, higher tea consumption and circulating biomarkers were associated with greater skeletal muscle mass and strength, accompanied by distinct multi-omics features that may provide potential biological links between tea exposure and muscle-related outcomes. - Source: PubMed
Publication date: 2026/08/14
Hong ZhenLu ZilongShi RuiqiZheng SitingLuo JielingChen JuXie ZhiyongZheng Ju-ShengChen Yu-MingZhang Zheqing - Osteoarthritis (OA) is a highly prevalent chronic joint disorder and a major cause of disability worldwide, yet effective disease-modifying therapies remain unavailable. We aimed to identify plasma proteins causally associated with OA risk to screen potential therapeutic targets. - Source: PubMed
Publication date: 2026/07/07
Huang XinyunChen HaoWang XianghanWang QianHuang PeiguanWang XiaoxuHe Chunrong - Alcohol use disorder (AUD) can progress to alcohol-associated liver disease (ALD), yet early-stage ALD (eALD) remains poorly defined at the molecular level. We performed plasma proteomic and peptidomic analysis in 42 adults (AUD = 10, eALD = 26, healthy volunteers = 6) using LC-MS/MS and pathway enrichment. Individuals with eALD exhibited greater alcohol burden, elevated liver injury markers (AST and ALT), and increased gut-immune dysfunction markers, including lipopolysaccharide, TNF-α, and K18M65, compared with AUD. Proteomic profiling identified 23 dysregulated peptides, with fibrinogen alpha (FIBA), fibrinogen beta (FIBB), COL1A1, and ITIH4 as key candidates. FIBB and COL1A1 were associated with AST, while FIBA and COL1A1 distinguished eALD from AUD. These findings identify circulating peptide biomarkers reflecting gut-immune-liver axis dysfunction and support their potential utility for non-invasive detection of early alcohol-associated liver disease. - Source: PubMed
Publication date: 2026/06/30
Kumari AnjaliSriwastva MukeshMerchant MichaelDolin ChristineArteel GavinWaigel SabineKong MaiyingSchwandt Melanie LVerster JorisSingal Ashwani KJala Venkatakrishna RMcClain Craig JVatsalya Vatsalya