Mouse Apo-H ELISA
- Known as:
- Mouse Apo-H Enzyme-linked immunosorbent assay test
- Catalog number:
- kt-7483
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Mouse Apo- ELISA
Related genes to: Mouse Apo-H ELISA
- Gene:
- APOM NIH gene
- Name:
- apolipoprotein M
- Previous symbol:
- -
- Synonyms:
- ApoM, G3a, NG20
- Chromosome:
- 6p21.33
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-02
- Date modifiied:
- 2016-10-05
- Gene:
- TNFRSF10A NIH gene
- Name:
- TNF receptor superfamily member 10a
- Previous symbol:
- -
- Synonyms:
- DR4, Apo2, TRAILR-1, CD261, TRAILR1
- Chromosome:
- 8p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-04
- Date modifiied:
- 2018-01-25
- Gene:
- TNFSF10 NIH gene
- Name:
- TNF superfamily member 10
- Previous symbol:
- -
- Synonyms:
- TRAIL, Apo-2L, TL2, CD253
- Chromosome:
- 3q26
- Locus Type:
- gene with protein product
- Date approved:
- 1998-12-04
- Date modifiied:
- 2017-03-02
Related products to: Mouse Apo-H ELISA
Related articles to: Mouse Apo-H ELISA
- Mesothelin (MSLN)-targeted chimeric antigen receptor (CAR)-T cell therapy shows an effective and long-lasting response in high MSLN-expressing tumors, but fails to treat tumors with heterogeneous levels of antigen expression. Here we describe an innovative approach where a stable tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) chimera, referred to as membrane-bound (MB)-TRAIL, is expressed on the cell surface of MSLN-specific (M28z) CAR-T cells. This potentiates their overall anticancer activity by overcoming heterogeneous antigen expression in tumor lesions. - Source: PubMed
Publication date: 2026/05/21
Volpe AlessiaZurita JuanShenker LarissaMane Mayuresh MAdusumilli Prasad SAleshin AlexanderRozanov DmitriPonomarev Vladimir - Gentiopicroside (GPS) has reported anti-inflammatory and neuroprotective effects. This research aimed to explore the reparative impacts and molecular mechanisms of GPS on brain injury in acute phase of middle cerebral artery occlusion (MCAO). - Source: PubMed
Publication date: 2026/05/21
Kui LingWang GuoyunZhang LiLiao QifengLi XiWang ShuangshuangChen TaoLeng BingfengHuang JinqunJiao YinmingYe QiaoyuanZeng QingqianXiong Kexu - Testicular germ cell tumors (TGCTs) are malignant neoplasms with a poor prognosis, and the absence of reliable biomarkers for patient stratification and diagnosis presents a significant challenge. - Source: PubMed
Publication date: 2026/04/28
Liu GuangminDu LinLv ShanshanLiu ZhizhongCao JianFan LiqingZhang ShushengXu KongrongXue Lei - Feline chronic gingivostomatitis (FCGS) is a debilitating oral disease characterized by immune dysregulation and chronic inflammation. We hypothesized that CD8 + T cells from FCGS cats exhibit exhaustion features with suppressed mitochondrial pathways, and that mesenchymal stromal cell (MSC) therapy post-extractions might restore these programs. RNA sequencing was performed on peripheral CD8 + T cells from cats with active FCGS before (disease group, D) and after (treated group, M) clinical remission following full-mouth extractions and MSC therapy, with specific-pathogen-free cats as controls (control group, C). CD8 + T cells from active disease displayed terminal effector differentiation and exhaustion-like signatures, including upregulation of cytotoxic markers (GZMB, GZMK, GZMA), differentiation markers (KLRG1, IL18R1/IL18RAP), and exhaustion-associated genes (EOMES, CD244, TNFSF10, CCR5, PRDM1, RGS16). Gene set enrichment analysis confirmed exhaustion-like CD8 + T-cell phenotype enrichment in active disease, which resolved after treatment. Pathway analysis revealed marked downregulation of mitochondrial respiratory chain components, ATP synthesis, and protein import pathways in active FCGS, with partial post-treatment resolution. Immunofluorescence of draining lymph nodes showed significantly increased CTLA-4 + CD3+ T cells in both FCGS groups versus controls, suggesting persistent immunoregulatory signaling despite clinical improvement. These findings identify overlapping T-cell exhaustion and mitochondrial dysfunction-associated transcriptomic signatures in FCGS, supporting therapeutic strategies targeting immune-metabolic pathways. - Source: PubMed
Publication date: 2026/05/06
Soltero-Rivera MariaWanakumjorn PatrawinChen YihongBarnum SamanthaCharpentier Luis Diego CastilloArzi BoazArzi Natalia VapniarskyKol Amir - Macrophage polarization and endoplasmic reticulum (ER) stress play critical yet incompletely understood roles in cancer progression and therapeutic resistance. - Source: PubMed
Publication date: 2026/04/30
Long ShengrongXiao KeweiHao Zhipeng