Mouse PAI1 ELISA
- Known as:
- Mouse PAI1 Enzyme-linked immunosorbent assay test
- Catalog number:
- kt-52470
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Mouse PAI1 ELISA
Related genes to: Mouse PAI1 ELISA
- Gene:
- SERPINE1 NIH gene
- Name:
- serpin family E member 1
- Previous symbol:
- PLANH1, PAI1
- Synonyms:
- PAI
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2019-04-23
Related products to: Mouse PAI1 ELISA
Related articles to: Mouse PAI1 ELISA
- This study aimed to explore the biological and clinical roles of polyamine-related genes (PRGs) in hepatocellular carcinoma (HCC) and to construct a PRG-based prognostic signature for prognostic assessment and precision therapy guidance in HCC. Twenty-two PRGs were retrieved from the Molecular Signatures Database. Transcriptome, clinical, and somatic mutation data of HCC were integrated from The Cancer Genome Atlas, International Cancer Genome Collaboratory, National Omics Data Encyclopedia, and Gene Expression Omnibus. Consensus clustering identified PRG subtypes, and gene set variation analysis screened differentially-expressed genes. Univariate Cox, Least Absolute Shrinkage and Selection Operator, and multivariate Cox regression analyses were used to construct a prognostic signature, validated in internal and 4 external cohorts. Immune infiltration was analyzed via single-sample gene set enrichment analysis, CIBERSORT, and ESTIMATE. The signature's predictive value for chemotherapy, transcatheter arterial chemoembolization, and immunotherapy was assessed with GDSC, tumor immune dysfunction and exclusion and relevant therapy cohorts, and its performance was compared with 4 published HCC signatures. The expression of signature genes was verified at the mRNA, protein, and single-cell levels. Two PRG subtypes were identified in HCC. Cluster A correlated with poor prognosis, high immune infiltration, and low metabolic activity. A 4-gene signature (KIF20A, SPP1, PON1, and SERPINE1) was established, effectively stratifying HCC patients into high- and low-risk groups with significantly different overall survival. It was an independent prognostic factor with better predictive performance than published signatures, and the high-risk group had a higher TP53 mutation rate, distinct immune infiltration patterns, and was predicted to have poor therapy responses. The 4 signature genes showed abnormal expression in HCC tissues at multiple levels. This study identified 2 PRG subtypes and a robust 4-gene prognostic signature for HCC, which accurately predicts prognosis, reflects tumor immune microenvironment features, and guides precision therapy selection, highlighting PRGs' potential as HCC biomarkers and therapeutic targets. - Source: PubMed
Shi WenjieShi WenxiangQiu Chenjie - To explore the potential benefits and risks of glucose-lowering drugs on cardiovascular-kidney-metabolic (CKM) syndrome outcomes using drug-target Mendelian randomization (MR). - Source: PubMed
Publication date: 2026/05/11
Lu JianSun ShuaigangShang XinruJiang ShiminDeng ZekaiWang ShunweiWei ChenpingHu JiaqiLi Wenge - Extreme cold causes myocardial injury; however, cold acclimation (CA) enhances myocardial tolerance. This study investigated whether brown adipose tissue (BAT)-derived extracellular vesicles (BAT-EVs) contribute to CA-induced cardioprotection. - Source: PubMed
Publication date: 2026/06/19
Zhang KaiHao YuweiLi NingxinMeng BingbingLiu ChangZhang XiaoyingLou JingshengFu QiangLiu YanhongCao JiangbeiQuan ChengMi WeidongLi Hao - Endometriosis (EMs) is a chronic, estrogen-dependent gynecological disorder characterized by the ectopic growth of endometrial tissue outside the uterus. Zinc Finger Protein 143 (ZNF143) is a DNA-binding transcription factor, yet its role in endometriosis remains unknown. Here, we report that ZNF143 is significantly upregulated in ectopic endometrial lesions. In vivo, we utilized PgrZfp143 mice, in which Zfp143 is deleted in both uterine epithelial and stromal cells since progesterone receptor expression in these compartments. We found that uterine-specific deletion of Zfp143 in this model markedly reduced lesion formation and growth. In contrast, epithelial-specific deletion using Sprr2fZfp143 mice, where Sprr2f is selectively expressed in uterine epithelial cells, showed no significant effect, indicating that ZNF143 primarily functions in endometrial stromal cells. In vitro, ZNF143 promoted stromal cell migration and invasion while knockdown of ZNF143 using siRNA transfection inhibit migration and invasion of hTERT-immortalized human endometrial stromal cells (T-HESCs) and primary human endometrial stromal cells (phESCs). ZNF143 deficiency also reduces collagen deposition in ectopic lesions, implicating it in fibrotic remodeling. Transcriptomic profiling identified Plasminogen Activator Inhibitor-1 (SERPINE1) as a key downstream effector mediating ZNF143-driven fibrosis, and SERPINE1 silencing attenuated these pro-fibrotic effects. Collectively, our findings establish ZNF143 as a critical transcriptional regulator especially in endometrial stroma that drives lesion progression and fibrosis in endometriosis, providing new mechanistic insights and highlighting a promising therapeutic target. - Source: PubMed
Publication date: 2026/06/18
Zhang KekeLi GuojingLi ChendiOuyang JingLuo LiujingYao YutongZhu ChenfengZhang PingLiang YanLin YuXu Hong - Doxorubicin (DOX) is a widely used chemotherapeutic agent, but its severe cardiotoxicity limits its clinical application. Many biological processes and molecular mechanisms have been implicated in DOX-induced cardiotoxicity. However, the mechanisms underlying DOX-induced cardiotoxicity remain largely unknown. This study aimed to identify key regulatory genes and select targeted drugs for DOX-induced cardiotoxicity. - Source: PubMed
Publication date: 2026/06/14
Mao CongZhang ZhuoXiao DabaoHe JunruLeng XuZhao WenzhenZeng MengyaZhong KeyanChen Yuewu