Human ICAM1 ELISA
- Known as:
- Human ICAM1 Enzyme-linked immunosorbent assay test
- Catalog number:
- kt-18646
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Human ICAM1 ELISA
Related genes to: Human ICAM1 ELISA
- Gene:
- ICAM1 NIH gene
- Name:
- intercellular adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- BB2, CD54
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-04-24
- Date modifiied:
- 2016-01-15
Related products to: Human ICAM1 ELISA
Related articles to: Human ICAM1 ELISA
- The ruminal epithelium maintains livestock health by absorbing nutrients while maintaining a tight barrier between the lumen and the plasma space. This study demonstrates that rumen organoid-derived 2D cultures approximate native tissue architecture and reach greater epithelial purity than primary cultures, particularly at later passages. For the initial transcriptomic and structural comparison, cells isolated from stratum basale by fractional trypsinization, were used to generate model epithelia on cell culture inserts either from early-passage primary cultures ( passage 3) or after organoid expansion ( passage 10). Transcriptomic analysis was used to compare the primary culture inserts, the organoid-derived inserts and the native tissues from which they had been derived. While both cell culture models yielded epithelial-like growth with barrier formation (TER >400 Ω×cm), transcriptomic analysis revealed higher expression of fibroblast-/mesenchymal stromal ECM markers () in the inserts from the primary cultures. Additionally, extracellular matrix (ECM)-remodeling genes () were upregulated in primary culture inserts, suggesting increased tissue remodeling activity in conjunction with the expression of inflammatory mediators (). Organoid-derived inserts showed less affected mitochondrial pathways (Cytochrome c oxidase (), synthase genes) and ribosomal machinery (), while maintaining epithelial purity with no detectable fibroblast or immune cell contamination. The expression of mRNA for numerous short-chain fatty acid (SCFA) transporters is confirmed, including MCT1, MCT4, DRA, PAT, SMCT1, AE2, and . This study establishes organoids as a physiologically relevant model for studying rumen epithelial physiology. - Source: PubMed
Publication date: 2026/06/02
Khomeijani Farahani SaeedLiebe FranziskaManna SubhakankhaWeiß FranziskaStumpff FriederikeGünzel Dorothee - Diabetic kidney disease (DKD) is characterized by tubular EMT and fibrosis. So far, the pathogenesis of DKD is still not fully understood. Pentraxin 3 (PTX3), an inflammatory regulator, is overexpressed in DKD due to hyperglycemia. PTX3 amplifies inflammation by promoting inflammatory cytokine release (TNF-α, IL-6) and activating the nuclear factor kappa-B (NF-κB) pathway. Subsequently, it triggers the c-Jun N-terminal kinase (JNK) signaling pathway, enhancing AP-1-mediated transcription of inflammatory genes (MCP-1, ICAM-1). JNK also upregulates EMT markers (α-SMA, N-cadherin) through increased transforming growth factor TGF-β1, accelerating renal fibrosis. Targeting the PTX3-JNK axis with neutralizing antibodies or inhibitors mitigates inflammation and EMT, suggesting PTX3 as a potential anti-fibrotic target in DKD. - Source: PubMed
Publication date: 2026/05/20
Ma XuezhenMa ChuntaoZhou XiaochunWang JianqinZhang WenkaiNiu QiaoqiaoLi XuanZhang Yaxin - To determine whether baseline immune activation and inflammation contribute to heterogeneity in SARS-CoV-2 vaccine-induced immunity in antiretroviral therapy (ART)-treated people with HIV (PWH) compared to HIV-negative controls. - Source: PubMed
Publication date: 2026/06/02
Moussaou Majdouline ElLadang AurélieMaes NathalieCavalie EtienneGenderini FrancescoeDahma HafidMartin CharlotteDauby NicolasDarcis Gilles - Autoimmune rheumatic diseases (ARDs) are characterized by excessive immune system dysregulation and a significant inflammatory milieu that provokes multiorgan damage. Inflammation holds a key role in the pathophysiology of cardiovascular disease (CVD), thereby explaining the increased cardiovascular risk of patients with ARDs. Among all cardiovascular risk factors, hypertension is the most prevalent one in patients with ARDs. The pathogenesis of hypertension in ARDs is multifactorial and the result of a complex interplay between several traditional cardiovascular risk factors, the sympathetic nervous system, autoimmune disease specific factors and genetic predisposition. Importantly, even though patients with ARDs and hypertension suffer a markedly increased cardiovascular risk, current guidelines lack a widely accepted risk prediction tool to accurately estimate CVD risk and provide a highly individualized approach. This review aims to analyse the prevalence and pathophysiology of hypertension in patients with ARDs and provide an overview of cardiovascular risk assessment in this high-risk group. - Source: PubMed
Publication date: 2026/04/30
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Publication date: 2026/05/30
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