TNF-alpha, Soluble (mouse recombinant)
- Known as:
- TNF-a, Soluble (mouse Rec.)
- Catalog number:
- tn-001
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- TNF-alpha Soluble (mouse recombinant)
Related products to: TNF-alpha, Soluble (mouse recombinant)
Related articles to: TNF-alpha, Soluble (mouse recombinant)
- To elucidate the therapeutic mechanism of Qufengzhitong Pills (QFZTP) in the treatment of rheumatoid arthritis (RA). - Source: PubMed
Li JieLi RongxueWang YuleRashed Marwan M AQi DejunHe YuanjieHe ChenghuiChang YanxuNian SihuiDuan HongHu HengguiZhai Kefeng - Psoriasis is a chronic skin disease that results in scaly patches and affects 2-3% of people worldwide. Therapeutic treatment targets the TNF-α/IL-17 axis to disrupt keratinocyte hyperproliferation and inflammation. While more is known about the role of dermal αß and γδ T cells in IL-17 production, less is understood about the role of resident epidermal T cells. Here, we examine how TNF-α modulates epidermal γδ T cell activation and function. We show that a subset of activated epidermal γδ T cells expresses TNFR2 with or without TNFR1. Stimulation with TNF-α induces epidermal γδ T cells to produce IL-17 family cytokines and chemokines. Epidermal γδ T cells do not require TNFR1 or 2 for development or homing to the skin. Instead, TNFR2 plays roles in epidermal γδ T cell function skewing them toward a Tγδ17 phenotype during psoriasis. Investigation of the mechanisms by which TNF-α associated inflammation impacts epidermal γδ T cell function may help identify new cellular targets for immunotherapy or mark them as early regulators of skin inflammation. - Source: PubMed
Publication date: 2026/06/23
Ahmed JasmineMatthews CarolynTulloch PatriciaLawler WilliamMendoza AlbertRhoiney MikaelaJameson Julie M - The health consequences of Plasmodium infections in wild great apes, particularly in asymptomatic animals, remain poorly understood. This study investigated the hematological and immune impacts of natural malaria infections in 27 semi-wild chimpanzees (Pan troglodytes troglodytes) from Gabon. Using PCR and qPCR to identify infected individuals, and MinION sequencing to determine the Plasmodium species involved, results showed a 48.15% overall Plasmodium infection rate, with frequent multi-species co-infections involving Plasmodium gaboni, Plasmodium reichenowi, and Plasmodium vivax-like parasites. In addition, infected chimpanzees were younger than non-infected individuals, although no significant association was detected between age and parasitemia levels, and this interpretation should be considered cautiously given the limited number of juvenile animals included in the study. Multi-species infections, particularly triple infections involving P. vivax-like parasites, were associated with higher parasitemia levels. Profiling of 15 hematological markers and 8 cytokines/chemokines known to be associated with malarial infections in humans revealed significant alterations in infected chimpanzees, including elevated urea, reduced creatinine, and increased systemic concentrations of pro-inflammatory (TNF, IL-1β, CCL3) and anti-inflammatory (IL-10) cytokines. Ex vivo PBMC stimulation yielded higher IL-10 in infected than non-infected individuals, indicating a regulatory-skewed cytokine response at the time of sampling. These results suggest that malaria in chimpanzees is associated with systemic immune modulation and accompanied by signs of physiological stress, including potential renal dysfunction. This study challenges the assumption that chronic Plasmodium infections are entirely benign in great apes and highlights the need to integrate immunological health indicators into conservation strategies. Broader immune profiling and longitudinal studies will be essential in the future to assess long-term health outcomes and resilience in these endangered populations. - Source: PubMed
Publication date: 2026/06/23
Nowakowski AnaisElguero EricPatterson KatieBoissière AnneDegrugillier FannySidobre ChristineArnathau CelineGrentzinger PaulineWillaume EricTalman Arthur MMalleret BenoitBoundenga LarsonNgoubangoye BarthelemyPrugnolle FranckWassmer Samuel CRougeron Virginie - Bletilla striata is highly regarded in traditional Chinese medicine and has also gained widespread attention as a valuable medicinal plant resource. However, the molecular composition and bioactive potential of its polysaccharides present a significant knowledge gap. Herein, a specific glucomannan fraction, designated as BSP60, was purified from Bletilla striata tubers and subsequently subjected to structural, rheological, and biological evaluations. Comprehensive characterization via methylation-GC-MS, monosaccharide composition analysis, and 1D and 2D NMR techniques demonstrated that BSP60 possesses a β-(1 → 4)-linked backbone featuring alternating mannosyl and glucosyl units, with the mannose moieties exhibiting partial O-acetylation at their C-2 or C-3 positions (with an acetylation rate of 23.54%). Rheological studies showed that BSP60 aqueous solutions exhibit shear-thinning behavior and form an elastic-dominated viscoelastic network, with higher viscosity and storage modulus than dextran of comparable molecular weight, indicating enhanced intermolecular interactions. Biological assays revealed that the BSP60 effectively decreased the level of NO, IL-6, and TNF-α in LPS-triggered macrophages (RAW264.7). Furthermore, the scavenge ability of BSP60 to superoxide anion (O) and ABTS radicals are significantly higher than that of hyaluronic acid. This study systematically characterizes the structural features of glucomannan derived from Bletilla striata, thereby establishing a robust scientific basis for its expanded utilization in the development of biomedical materials and functional cosmetic ingredients. - Source: PubMed
Publication date: 2026/06/23
Li XuanGu QinghuiHu QileDeng TuoLuo LanCai JianpingDong XudongWu ChunhuaWu Mingyi - The gut-lung axis is a bidirectional communication network linking intestinal and pulmonary homeostasis through shared immunological and molecular mechanisms, conceptually consistent with the traditional Chinese medicine theory of "lung-intestine combined treatment." Polygonatum cyrtonema Hua is an edible medicinal plant with reported anti-inflammatory and antioxidant properties, yet its role in intestinal inflammation-associated lung injury remains unclear. - Source: PubMed
Publication date: 2026/06/23
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