Polyclonal PIST (CT)
- Known as:
- Polyclonal PIST (CT)
- Catalog number:
- pc-556
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Polyclonal PIST ()
Related genes to: Polyclonal PIST (CT)
- Gene:
- GOPC NIH gene
- Name:
- golgi associated PDZ and coiled-coil motif containing
- Previous symbol:
- -
- Synonyms:
- dJ94G16.2, PIST, FIG, GOPC1, CAL
- Chromosome:
- 6q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-29
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal PIST (CT)
Related articles to: Polyclonal PIST (CT)
- Infection of the large yellow croaker () embryo cell line YCE1 with megalocytivirus strain FD201807 leads to accumulation of capsid-deficient viral intermediates within intracellular vesicles at 48 h post-infection (a phenotype associated with non-lytic egress), which coincides with the initial peak of viral genomic copies. To characterize the host molecular response during this critical stage, we performed time-course RNA sequencing at 24, 48, 96, and 144 hpi. Integrated analysis identified 6661 differentially expressed genes (DEGs) and 1138 differential alternative splicing (DAS) events affecting 892 genes, with DAS event abundance peaking at 48 h. DAS genes in autophagy and Golgi vesicle transport pathways, both integral to animal innate immunity, were significantly enriched exclusively at this timepoint, featuring novel mutually exclusive exon (MXE) isoforms in (Golgi-associated PDZ and coiled-coil motif containing) and (RAD50 interactor 1). Weighted gene co-expression network analysis (WGCNA) of DEGs identified (mitogen-activated protein kinase 9) and (microtubule-associated protein 1 light chain 3 alpha) as hub genes within modules enriched for autophagy-related functions. Separate co-expression analysis of DAS genes revealed , , and as hub genes, with exhibiting only a single linkage to . These findings implied concurrent transcriptional and virus-induced host splicing regulation of vesicle-associated innate defense pathways and suggest that splicing-derived features may serve as potential candidates for diagnostics or prevention against megalocytivirus disease in . - Source: PubMed
Publication date: 2026/04/20
Zheng ZaiyuChi HongshuLiu XiaodongChen XiuxiaPan YingGong Hui - Declining in smoking prevalence may not correlate with reduced economic burden. This study aimed to estimate Hong Kong's economic burden of smoking using actual territory-wide public healthcare expenditure data. - Source: PubMed
Publication date: 2026/04/04
Chen TingtingWang BoyuanLee Ming HinChan Ka HungChan Sophia Siu CheeLi XueChui Sze Ling CelineLai Francisco Tsz TsunChan Esther Wai YinWong Ian Chi KeiWan Eric Yuk Fai - TCOF1 is a nucleolar protein involved in ribosome biogenesis, DNA damage response, and mitotic regulation. Germline mutations are associated with Treacher-Collins syndrome, a rare congenital disorder characterized by craniofacial abnormalities. Clear cell renal cell carcinoma (ccRCC), the most prevalent form of kidney cancer, exhibits pronounced nuclear and nucleolar pleomorphism, which correlates with tumour aggressiveness. The ccRCC grading system relies on microscopic evaluation of nuclear and nucleolar features. Here, we hypothesized that TCOF1 contributes to ccRCC tumorigenesis. - Source: PubMed
Publication date: 2026/03/17
Grzanka MałgorzataPopławski PiotrWiśniewski Jacek RIwanicka-Nowicka RoksanaKossowska HelenaKoblowska MartaRybicka BeataBiałas AlexPiekiełko-Witkowska Agnieszka - This study evaluated the quality and quantity of Goals of Patient Care (GoPC) documentation amongst older adults admitted under General Surgery at a tertiary hospital, comparing standards before and after integration of proactive geriatric medicine input via the Older Adult Surgical Inpatient Service (OASIS). - Source: PubMed
Kumarasinghe Anuttara Panchali WLeung LianneYoung DarciePugliese MatthewTrivedi AnandFoster Amanda - ALK and ROS1 fusions are key drivers of infant-type hemispheric gliomas (IHG). With diverse gene partners, the impact of ALK and ROS1 oncoprotein heterogeneity on glioma biology remains unknown. We developed an integrative phospho-proteomic and transcriptomic approach to discover biological functions regulated by five IHG-associated fusions: CCDC88A::ALK, PPP1CB::ALK, GOPC::ROS1, CLIP1::ROS1, and KIF21A::ROS1. Here, we report fusion-specific oncogenic functions conferred by the 5' gene partner, including increased cell motility driven by microtubule-interacting fusions CCDC88A::ALK and CLIP1::ROS1. All studied fusions converge on STAT3 activation. Using affinity purification mass spectrometry, we identified SHP2 in direct interaction with all three ROS1 oncoproteins but with none of the ALK oncoproteins, which in turn interact with SHC1/SHC3. ROS1 fusions phosphorylate SHP2 to a greater extent than ALK fusions, and analyses of downstream pathways suggest MAPK-independent, non-canonical SHP2-driven functions. Our findings reveal both common and fusion-specific dependencies, offering opportunities to optimize therapeutic strategies for pediatric gliomas. - Source: PubMed
Publication date: 2026/03/05
Postlmayr AndreasSanchez Bergman AstridTorrejon Diaz JacobCiraulo BernardYan ShenHofmann NinaCarbajal SamantaDobler RosalieMachaalani CharbelSchönholzer Marc TPriego Gonzalez LauraDe Micheli Andrea JBerenjeno-Correa ErnestoBaroncini LucaGrotzer Michael ATabori UriHawkins CynthiaAyrault OlivierZuckermann MarcBaumgartner MartinGuerreiro Stücklin Ana S