Polyclonal TLR10 (IN)
- Known as:
- Polyclonal TLR10 (IN)
- Catalog number:
- pc-459
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Polyclonal TLR10 ()
Related genes to: Polyclonal TLR10 (IN)
- Gene:
- TLR10 NIH gene
- Name:
- toll like receptor 10
- Previous symbol:
- -
- Synonyms:
- CD290
- Chromosome:
- 4p14
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-27
- Date modifiied:
- 2016-01-21
Related products to: Polyclonal TLR10 (IN)
Related articles to: Polyclonal TLR10 (IN)
- Metastasis is the primary cause of mortality in patients with breast cancer. This study aimed to develop a prognostic signature based on metastasis- and cancer-associated differentially expressed genes (M-CA-DEGs) and to identify potential novel therapeutic genes. - Source: PubMed
Publication date: 2026/05/11
Yao YuanZheng YunshengXie JiancongLiu HonghaoChen ChenCao JieYin Ting-Ting - Improving disease resistance in cattle relies on informed breeding and vaccine development, both depend on our understanding of immune mechanisms in cattle. However, transcriptomic studies of bovine immune responses often show considerable variability due to differences in tissue type, pathogen, time point, and experimental design, limiting the generalizability. Meta-analysis integrates multiple transcriptomic studies to identify consistent gene expression patterns and enhance statistical power. We integrated bovine RNA-seq datasets using immune-response specific keywords, species constraints, and high-throughput sequencing filters to prioritize biologically comparable and meta-analysis-ready studies. Specifically, in this study, we performed a meta-analysis of four bovine transcriptomic datasets to identify immune-related differentially expressed genes (DEGs) in Bos taurus. These datasets showed consistent results across analyses and represent immune responses related to mycobacterial infections (Mycobacterium bovis and Mycobacterium avium subsp. paratuberculosis), making them suitable for combined analysis. Our pipeline included FastQC, Trimmomatic, Bowtie2, SAMtools, FeatureCounts, DESeq2, and MetaRNASeq, identifying 28 DEGs (12 upregulated and 16 downregulated). We identified key immune-related genes (IL1A, RGS2, RCAN1, ZBP1, TIMD4, PPARG, TLR10, and ACP5) with known regulatory roles in immunity. KEGG enrichment analysis revealed involvement in necroptosis, osteoclast differentiation, oxytocin signaling, and cGMP-PKG signaling pathways, associated with inflammatory cell death, cytokine signaling, and immune cell differentiation. Using reproducible transcriptomic signals across systematically selected bovine immune datasets rather than relying on single-experiment analyses, we provide a robust meta-analytic framework. This meta-analysis enhances our understanding of conserved immune signaling mechanisms in cattle for identifying conserved immune mechanisms with broader biological and translational relevance. - Source: PubMed
Marimuthu Vennila Kanchana DeviMatheswaran KishoreThambiraja MenakaOnteru Suneel KumarYennamalli Ragothaman M - Bone regeneration requires tight coordination between mesenchymal stem cells (MSCs), immune signaling, and extracellular matrix remodeling. Yet, how atypical immune receptors contribute to this process remains unclear. Here, we identify Toll-like receptor 10 (TLR10) as a key regulator of osteogenic differentiation in human adipose-derived MSCs. Herein, ASC/TERT1 MSCs were engineered to overexpress or silence TLR10 using lentiviral vectors, and osteogenic differentiation (0-14 days) was assessed by metabolic assays-RT-qPCR of , and -Alizarin Red S staining, and quantitative mass spectrometry. Enhancing TLR10 expression promoted osteogenic gene programs, extracellular matrix organization, metabolic adaptation, and robust matrix mineralization, whereas TLR10 suppression maintained proliferative states and impaired osteoblast maturation. Proteomic analyses revealed that TLR10 selectively activates osteogenic, ECM-remodeling, and vitamin D-responsive pathways, while restraining programs antagonistic to differentiation. Notably, active vitamin D induced TLR10 expression and partially restored osteogenesis in TLR10-deficient cells, indicating that TLR10 is associated with vitamin D-driven bone formation. Together, beyond its established role in innate immunity, TLR10 emerges as a vitamin D-responsive regulator of mesenchymal stem cell osteogenesis, highlighting a potential therapeutic axis to enhance bone regeneration and osteogenic outcomes. - Source: PubMed
Publication date: 2026/04/15
Stierschneider AnnaNeuditschko BenjaminFischer IsabellaHellmann EstherZimmermann DanielProhaska KaterinaMilchram LisaHerzog FranzWiesner Christoph - Inflammation is an important pathogenic factor that leads to thyroid follicular epithelial cells injury after Hashimoto's thyroiditis (HT). Recent studies proposed relationships between pyroptosis and apolipoproteins in HT. However, the molecular signatures involved in the pathophysiological changes that occur during the course of HT remain ambiguous. - Source: PubMed
Publication date: 2026/04/16
Sun BaihuiTan JieYu ShitongGe JunnaWei ZhigangLei ShangtongLi Guoxin - Cold stress is a significant challenge to buffalo health; however, the molecular mechanisms underlying their adaptation remain insufficiently explored. This study employed quantitative real-time PCR (qRT-PCR) to evaluate the relative gene expression of Toll-like receptors (–) in peripheral blood mononuclear cells (PBMCs) of Murrah buffalo calves ( = 6) exposed to graded ambient temperatures (24 °C, 21 °C, 18 °C, and 15 °C). Progressive cooling induced notable physiological changes, including a gradual decline in rectal temperature and respiration rate. Transcriptional activation was first detected at 21 °C for , , and , and expanded to include all examined TLR genes at 18 °C. Peak expression occurred at 15 °C, with , , and demonstrating the most pronounced upregulation. Segmented regression analysis indicated a potential transcriptional intensification between 18 °C and 21 °C for several genes, although these observations should be interpreted cautiously due to the limited sample size. Among the targets, exhibited the strongest inverse correlation with ambient temperature. Collectively, these findings provide insights into the buffalo-specific innate immune response to cold exposure and identify several TLRs as promising molecular indicators for monitoring cold stress resilience. - Source: PubMed
Publication date: 2026/04/11
Sharma VanshKumari PriyambadaYadav BrijeshKumari ReetuSingh Shanker KMadan Arun KTiwari Manish