Polyclonal BIN-1
- Known as:
- Polyclonal BIN-1
- Catalog number:
- pc-405
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Polyclonal BIN-1
Related genes to: Polyclonal BIN-1
- Gene:
- BIN1 NIH gene
- Name:
- bridging integrator 1
- Previous symbol:
- AMPHL
- Synonyms:
- SH3P9, AMPH2
- Chromosome:
- 2q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-19
- Date modifiied:
- 2019-04-23
Related products to: Polyclonal BIN-1
Related articles to: Polyclonal BIN-1
- Tumor necrosis factor α-induced protein 3 (TNFAIP3)-interacting protein 1 (TNIP1) is a ubiquitin-binding protein and central repressor of cytoplasmic inflammatory signaling. We have previously shown that TNIP1 is an intrinsically disordered protein (IDP) and that endogenous TNIP1 can be found in cytoplasmic puncta. These TNIP1 protein traits led us to hypothesize that it is capable of liquid-liquid phase separation (LLPS). Here we report the ability of TNIP1 to redistribute the otherwise diffuse signal of EGFP to puncta when the TNIP1-EGFP fusion protein is transiently expressed in HaCaT keratinocyte skin cells. Formation of these puncta is independent of TNIP1 binding to polyubiquitin. The C-terminal region of TNIP1 (amino acids 410-636) contains many of the features of the full-length protein in regard to presence of intrinsic disorder, low complexity regions, and predicted droplet formation. It reversibly forms liquid droplets mainly dependent on electrostatic interactions. While this C-terminal region of TNIP1 contains the protein's ubiquitin-binding region, droplet formation was independent of interaction with polyubiquitin; this observation was mirrored in cells. This sets its in vitro performance apart from other polyubiquitin-binding proteins. These findings have helped newly identify TNIP1 as a phase separating protein. They support future studies to examine the contribution of puncta on the repressing ability of TNIP1 and will broaden understanding of biomolecular condensates in regulating cytoplasmic inflammatory signaling. - Source: PubMed
Publication date: 2026/05/26
Carman Liam ESamulevich Michael LAbeywickrama Chathura SMurray Dylan TAneskievich Brian J - Beyond conventional transcriptome profiling, RNA-sequencing (RNA-Seq) enables the discovery of variants within expressed genes linked to complex traits such as mastitis resistance or susceptibility. In this study, RNA-Seq was performed on milk somatic cells from uninfected Holstein cows with no history of mastitis (Neg, n = 9) or with subclinical intramammary infections (sIMI) caused by Prototheca spp. (P+ , n = 11) or Streptococcus agalactiae (Sa+ , n = 11). The objective was to identify transcriptome-derived sequence variants detectable under specific microbiological conditions that may contribute to the modulation of host transcriptional responses. By integrating these transcript-derived variants with quantitative trait locus (QTL) annotations and enrichment analyses, we aimed to highlight genomic regions functionally associated with mastitis susceptibility or resilience. - Source: PubMed
Publication date: 2026/05/17
Vanzin AliceBisutti VittoriaCánovas ÁngelaCecchinato AlessioGallo LuigiGiannuzzi DianaPegolo Sara - Psoriasis is an autoimmune disorder, and about 125 million people worldwide suffer from this chronic skin disease. It is a multifactorial disorder influenced by the combined action of many genetic factors and their interactions with environmental factors. Recently, significant advances in research have provided greater insight into the pathophysiologic mechanisms, highlighting the roles of genetic susceptibility loci such as HLA-C*06:02, IL12B, and TNIP1, as well as immune pathways involving IL-17, IL-23, and TNF-α. These discoveries not only provided a better understanding of psoriasis but also played a vital role in developing treatment strategies. This review highlights immunological and genetic insights of psoriasis, emphasising their translational relevance. The review also covers how genetic variations modulate the immune response, leading to disease occurrence and chronicity. Moreover, the article explores how these findings are shaping personalised diagnosis and treatment strategies. This strategy holds the promise of enhancing the treatment of individuals with psoriasis by transitioning from the traditional care paradigm to patient-centred care in dermatology. - Source: PubMed
Publication date: 2026/05/13
Sugumaran DineshwarYong Audrey Chee HuiHow Kang NienStanslas Johnson - Erectile dysfunction (ED) is a prevalent complication of type 2 diabetes mellitus (T2DM). However, the role of RNA N6-methyladenosine (m6A) methylation in T2DM-associated ED remains unclear. - Source: PubMed
Meng ChunyangJiang JunJiang Rui - Hepatolithiasis (HL) is a prevalent condition in hepatobiliary surgery, often complicated by hepatatrophia. This study aimed to identify gene mutations in HL specimens with hepatatrophia and construct a mutation landscape using whole-exome sequencing (WES). - Source: PubMed
Publication date: 2026/04/09
Tang DanGu XuanyuLiu DanYang JialiZhao Lijin