Polyclonal TEM8
- Known as:
- Polyclonal TEM8
- Catalog number:
- pc-401
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Polyclonal TEM8
Related genes to: Polyclonal TEM8
- Gene:
- ANTXR1 NIH gene
- Name:
- ANTXR cell adhesion molecule 1
- Previous symbol:
- -
- Synonyms:
- TEM8, FLJ21776, FLJ10601, ATR
- Chromosome:
- 2p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-27
- Date modifiied:
- 2018-05-10
Related products to: Polyclonal TEM8
Related articles to: Polyclonal TEM8
- Anthrax toxin receptor 1 (ANTXR1, TEM8) has been implicated in tumor angiogenesis and progression, yet its pan-cancer immunological role remains incompletely defined. - Source: PubMed
Publication date: 2026/06/06
Qiu YueYu ZhuLai WeikunXu WenqianYang JianZhou SijiangChen Junqiang - An ester group can serve as a covalent warhead to acylate amino acid residues around the active cavity of the target protein, thereby silencing its biological function. In this study, taking 8-(benzoyloxy) cycloberberine (1) as the lead, twenty-seven 8-esterified cycloberberine (CBBR) derivatives were continuously synthesized and evaluated for their anti-tumor activities. Among them, compound 8a exhibited an appealing potency against a variety of tumor cells with IC values ranging 1.91-5.09 μM, significantly outperforming the lead 1. Cell cycle analysis showed 8a-induced G2/M phase arrest, which suggested ANTXR1 as a candidate target via thermal proteome profiling (TPP) assay. Further cellular thermal shift assay (CETSA) and surface plasmon resonance (SPR) analysis identified ANTXR1 as a direct target of 8a (K = 2.88 μM). LC-MS/MS, molecule docking and molecular dynamics simulations (MD) demonstrated that the 8-adamantane acetyl in 8a could undergo an acylation reaction with Ser229 of ANTXR1, thereby inhibiting tumor cell proliferation. Therefore, compound 8a is a covalent inhibitor of ANTXR1, and introducing an ester group as the chemical warhead represents a highly effective structural modification strategy in medicinal chemistry. - Source: PubMed
Publication date: 2026/05/15
Tang JiaMa XicanWang XueleiXia GuiminZhang XintongYu ZhihuiZhu JingyangLi XinyiWu ZhiyunMeng RunzeNi YananFan TianyunLi YinghongSong Danqing - The TEM8 receptor (coded by ANTXR1) plays several roles in oncogenesis and novel oncolytic therapies, such as the SVV-01 virus, uniquely bind this protein in neuroendocrine tumor (NET) histologies, such as small-cell lung cancer (SCLC). Emerging pre-clinical data suggest that TEM8-targeting therapies may convert immunologically "cold" tumor microenvironments (TME) into "hot" milieu with greater responses to immune checkpoint inhibitors (ICIs). - Source: PubMed
Publication date: 2026/03/22
Kareff Samuel AKrause HarrisElliott AndrewSamec TimothyLopes GilbertoHosein Peter JJani Chinmay TLou EmilSoares HeloisaMagistri MarcoSumarriva DanielOberley MatthewChauhan Aman - - Source: PubMed
Publication date: 2026/04/16
Chen DengyunLin LipingWu YiboHuang KunboZhang HanhuiChen Qingqing - Inherited blood disorders (IBDs) are a major health concern in the Kingdom of Saudi Arabia (KSA), largely due to the high prevalence of consanguineous marriages. - Source: PubMed
Publication date: 2026/04/01
Younis Nancy SAlkabsh Rahma MNasser Alqahtani Shahad MAljuail HajerAlhashim Manar ABokhamsin Shahad AAlbaqshi Layla JAlqadhib Salsabil FAldandan Jumanah AAlshakhs Zahra AAltaweel Maryam HMohamed Maged E