Polyclonal CETP
- Known as:
- Polyclonal CETP
- Catalog number:
- pc-355
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Polyclonal CETP
Related genes to: Polyclonal CETP
- Gene:
- CETP NIH gene
- Name:
- cholesteryl ester transfer protein
- Previous symbol:
- -
- Synonyms:
- BPIFF
- Chromosome:
- 16q13
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-03-17
Related products to: Polyclonal CETP
Related articles to: Polyclonal CETP
- Elevated cholesterol levels are associated with the risk of the most socially significant cardiovascular diseases, such as atherosclerosis, ischemic heart disease, and myocardial infarction. - Source: PubMed
Publication date: 2026/06/02
Mamchur AleksandraBruttan MariaDaniel VeronikaKashtanova DariaZelenova ElenaDzhumaniiazova IrinaIvanov MikhailMatkava LorenaBlinova OlgaMitrofanov SergeyGolubnikova LiliyaKumar NaianaMaralova EkaterinaShingaliev AndreyEzhov MaratMeshkov AlekseyChubykina UlianaPogorelova OlgaTripoten MariiaBalahonova TatyanaViskova AlexandraKomarova MadinaGurtsiev TimurGomyranova NataliaVorobeva YuliaHotuleva AnastasiaKolyaskina MariaYudin VladimirMakarov ValentinKeskinov AntonKuzmina LyudmilaBoytsov SergeyYudin SergeySkvortsova Veronika - Industrial effluent and common effluent treatment plant (CETP)-associated samples from Navi Mumbai, India, were screened for indigenous lead-tolerant bacteria. Among 32 isolates, EP-L-21 showed the highest Pb tolerance, with growth at the highest tested concentration (>2,000 mg/L) Pb, broad pH tolerance (pH 4-10), and robust growth across 20-37 [Formula: see text]C, with consistent optical density at 600 nm (OD[Formula: see text]) values indicating broad temperature tolerance under Pb stress. VITEK 2 identification and whole-genome sequencing (WGS) assigned EP-L-21 to Klebsiella pneumoniae (K. pneumoniae) sequence type 86 (ST86). The draft genome (5.38 Mb; 57.3 mol% GC; 46 contigs) encoded metal-resistance and stress-response determinants, including resistance-nodulation-division (RND)-family efflux systems, P-type ATPases, oxidative stress-associated genes. In addition, enterobactin- and aerobactin-associated siderophore biosynthetic clusters were identified, which may contribute indirectly to metal-stress adaptation under iron-limited and metal-stressed conditions; no canonical czcCBA operon was detected. In Luria-Bertani (LB) broth containing a measured initial supernatant-associated Pb concentration of 88.40 ± 0.43 mg/L, residual supernatant-associated Pb decreased to 0.58 ± 0.43 mg/L after 72 h, corresponding to 99.34% removal, whereas abiotic controls showed negligible Pb loss. Pb reduction over time was statistically significant ([Formula: see text]). Mass-balance analysis indicated that >99% of removed Pb was associated with non-supernatant fractions, although surface-bound, intracellular, and precipitated pools were not independently resolved. EP-L-21 also exhibited tolerance to Ni, with intermediate resistance to Cr, Cd, and sensitivity to Hg at lower concentrations. Genome analysis predicted the presence of antimicrobial resistance (AMR) and virulence-associated determinants, therefore, the strain should be considered an environmental opportunist and is suitable only for contained bioreactor-based applications, with environmental release not recommended. These findings link high-level Pb tolerance with a predicted multimetal resistome and support further mechanistic validation in contained bioprocess systems. - Source: PubMed
Publication date: 2026/06/16
Kala Vineet D PTripathi Arpana RChavan Kartikey JGhorpade Rajeshri PNayak Shubhada S - Patients with cardiovascular disease have increased risk of chronic kidney disease progression. Low levels of high-density lipoprotein (HDL) or HDL dysfunction have been implicated in progressive deterioration of renal function. We investigated the impact on renal function of obicetrapib, a cholesteryl ester transfer protein (CETP) inhibitor that raises apolipoprotein A1 and HDL cholesterol (HDL-C) and improves HDL function. - Source: PubMed
Publication date: 2026/03/24
Vogt LiffertDavidson Michael HSzarek MichaelKling DouglasDicklin Mary RCurcio DanielleDitmarsch MarcHsieh AndrewWicks Douglas LOrtiz NancyKastelein John J P - Metabolic syndrome involves several lipid-related genes, including apolipoprotein A5 (APOA5), lipoprotein lipase (LPL), and cholesteryl ester transfer protein (CETP). Although individual SNP susceptibility has been reported, gene-gene interactions remain underexplored. To address this gap, we apply many-objective multifactor dimensionality reduction (MaODR)-previously developed by our group-to detect gene‒gene interactions in unbalanced newly identified MetS and non-MetS subjects. - Source: PubMed
Publication date: 2026/06/09
Lin Yu-DaLuo Kuei-HauChuang Li-YehChuang Hung-YiYang Cheng-Hong - CETP (cholesteryl ester transfer protein) plays an important role in lipid metabolism, facilitating the exchange of esterified cholesterol for triglycerides between lipoproteins. Genetic and cohort studies have demonstrated the presence of low CETP associates with lower rates of cardiovascular disease, diabetes, and neurodegeneration. However, early development programs of pharmacological CETP inhibitors proved disappointing with evidence of off-target toxicity, clinical futility, or marginal cardiovascular benefit with adipose tissue accumulation. Subsequent investigation of these programs and genomic studies has identified a pathway for drug development, in which promoting the ability of CETP inhibitors to lower levels of atherogenic lipids and lipoproteins and exerting a favorable impact on glycemic control may translate to reductions in cardiovascular risk, as opposed to the original motivation to raise HDL (high-density lipoprotein) cholesterol levels. Obicetrapib is a highly selective CETP inhibitor with evidence of favorable effects on atherogenic lipids and lipoproteins, glycemic control, and biomarkers of beta-amyloid pathology in preclinical Alzheimer disease. The ongoing potential for CETP inhibition as an effective tool in the prevention clinic and other emerging applications will be reviewed. - Source: PubMed
Publication date: 2026/06/04
Nicholls Stephen JRay Kausik KNelson Adam JKastelein John J