Polyclonal GFR alpha-1
- Known as:
- Polyclonal GFR a-1
- Catalog number:
- pc-072
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Polyclonal GFR alpha-1
Related genes to: Polyclonal GFR alpha-1
- Gene:
- RALGAPA1 NIH gene
- Name:
- Ral GTPase activating protein catalytic alpha subunit 1
- Previous symbol:
- GARNL1
- Synonyms:
- GRIPE, DKFZp667F074, KIAA0884, Tulip1, RalGAPalpha1
- Chromosome:
- 14q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-09
- Date modifiied:
- 2018-11-19
- Gene:
- SERPINA1 NIH gene
- Name:
- serpin family A member 1
- Previous symbol:
- PI
- Synonyms:
- AAT, A1A, PI1, alpha-1-antitrypsin, A1AT, alpha1AT
- Chromosome:
- 14q32.13
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
- Gene:
- TMED11P NIH gene
- Name:
- transmembrane p24 trafficking protein 11, pseudogene
- Previous symbol:
- -
- Synonyms:
- p24alpha1, p24a1
- Chromosome:
- 4p16.3
- Locus Type:
- pseudogene
- Date approved:
- 2009-01-06
- Date modifiied:
- 2015-08-11
Related products to: Polyclonal GFR alpha-1
Related articles to: Polyclonal GFR alpha-1
- Dental enamel proteomics provides access to molecular information from time periods far beyond the reach of ancient DNA, offering a powerful means to investigate evolutionary dynamics in deep time. Here we present the first large-scale enamel proteomic dataset for 55 cave bears to date, analysing fossils spanning the Early to Late Pleistocene across southwestern Europe, including key specimens from Atapuerca sites. Using a non-enzymatic demineralization workflow and LC-MS/MS analysis we consistently recovered rich enamel proteomes and identified taxonomically informative peptides alongside two previously unknown amino acid variations in AMBN-249 and SERPINA1-341 positions. Phylogenetic analyses are consistent with a basal position of Ursus dolinensis within the speleoid clade, providing new molecular evidence relevant to its debated taxonomy. Together, these findings show that enamel proteomes preserve phylogenetic structure and lineage-specific molecular signals, highlighting the potential of palaeoproteomics to inform evolutionary relationships within the speleoid clade across the Pleistocene. - Source: PubMed
Publication date: 2026/06/24
Gutiérrez-Carbajal AmandaSantos ElenaLizano EstherMarques-Bonet TomasFong-Zazueta RicardoGrandal-d'Anglade AuroraAlba David MGarcía-Vázquez AnaGómez-Olivencia Asierde Alvarado Mónica VillalbaPandolfi LucaRook LorenzoSanz MontserratDaura JoanZilhão JoãoArsuaga Juan Luisde Castro José María BermúdezMartinón-Torres María - COVID-19 has been closely associated with coagulation abnormalities. However, existing biomarkers, including D-dimer and fibrin degradation products (FDP), exhibit limited accuracy in stratifying disease severity and predicting long-term clinical outcomes. - Source: PubMed
Publication date: 2026/06/21
Zhou ZizhenLiu QiweiMa ShuangshuangShi AnkeTao YuzhiHu TianpengYan ShengtaoChen YinongJi XiaofanSun LuZhang HongSong WanluZhang ZhuYang PeiranZhai Zhenguo - Proteomic profiling offers thorough insights into protein structure and function, as well as it acts as an essential approach for analyzing molecular changes at the tissue level. However, because of the proteome's diversity and dynamic nature, biomarker discovery remains challenging. By combining proteomics with bioinformatics, the level of understanding in relation to molecular interactions and disease processes can be improved. Through an integrative approach, few limitations can be addressed, thereby promoting proteomic profiling for the discovery of new therapeutic targets and novel biomarkers for a variety of disorders. - Source: PubMed
Publication date: 2026/06/18
Rao Bounika EsvanthNair Anju MRamesh PreethiRamshankar VijayalakshmiGopinath SAbhinand P ANdkoraj ArtnoraMazur MartaWarnakulasuriya SamanCatakapatri Venugopal Divyambika - This study aimed to investigate the effect of inactivated SARS-CoV-2 vaccines and booster shots on serum glycan profiles and protein N-glycosylation, specifically how vaccination influences glycan synthesis over time, how booster shots differentially impact populations with varying antibody titers, and which specific glycoproteins exhibit altered glycosylation. The goal was to explore a novel mechanism by which COVID-19 vaccines might exert antiviral effects through indirect inhibition of host glycosylation. - Source: PubMed
Zhou YufengChen YanDai TianqinJia XingwangYang ShuangLiu Qing - Leptospirosis is a globally neglected zoonotic disease caused by pathogenic species and characterized by diverse clinical manifestations. However, the molecular immune responses occurring in circulating human immune cells during acute infection remain incompletely understood. Although several leptospiral virulence determinants have been investigated, a detailed characterization of host immune signaling during human infection is still limited. To characterize host molecular responses during acute leptospirosis, we performed integrated transcriptomic and proteomic profiling of peripheral blood mononuclear cells (PBMCs) from laboratory-confirmed leptospirosis patients and healthy controls. PBMCs were selected because they contain circulating immune cells involved in pathogen recognition and cytokine signaling, enabling focused analysis of host immune responses. Multi-omics network analysis was used to identify conserved immune pathways, and key host factors were further examined using human whole-blood infection models and infection of human macrophages and monocytes. Transcriptomic profiling identified over 5,800 differentially expressed genes, predominantly upregulated, and associated with inflammatory signaling, including tumor necrosis factor signaling, interferon responses, and cytokine-mediated immune activation. Proteomic analyses detected 362 differentially expressed proteins in clinical PBMC samples and 818 differentially expressed proteins in the experimental infection model, with overlapping proteins defining a conserved host response. Comparative analysis identified 16 consistently upregulated host factors enriched in pathways related to neutrophil activation, hemostasis, and cytokine signaling. Quantitative RT-PCR confirmed increased expression of and supporting their roles in inflammatory signaling and acute-phase immune responses. Together, these findings reveal conserved immune pathways activated during acute infection and provide molecular insights into host-pathogen interactions in human leptospirosis.IMPORTANCELeptospirosis is a globally important zoonotic disease caused by bacteria of the genus . It can lead to severe systemic complications such as kidney failure, lung injury, and multi-organ dysfunction in affected individuals. Accumulating evidence indicates that these severe clinical manifestations are closely associated with dysregulated host immune and inflammatory responses triggered during infection. However, the molecular mechanisms underlying these immune responses, particularly the transcriptional and proteomic alterations occurring in human immune cells during infection, remain incompletely understood. In this study, we analyzed immune cells from patients with leptospirosis and identified key host molecules and immune pathways activated during infection. Experiments using human blood and immune cell models confirmed the involvement of several inflammatory host factors. These findings improve our understanding of how the human immune system responds to infection and identify host-response molecules that may help guide future biomarker discovery and therapeutic strategies. - Source: PubMed
Publication date: 2026/06/15
Cp JusailVyas PallaviNoor HudaKavela SridharKodugade Mansoor AKammili NagamaniFaisal Syed M