Polyclonal IRAK2 (C2)
- Known as:
- Polyclonal IRAK2 (C2)
- Catalog number:
- pc-044
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Kamiya biomedical company
- Gene target:
- Polyclonal IRAK2 (C2)
Related genes to: Polyclonal IRAK2 (C2)
- Gene:
- AAR2 NIH gene
- Name:
- AAR2 splicing factor
- Previous symbol:
- C20orf4
- Synonyms:
- bA234K24.2
- Chromosome:
- 20q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-21
- Date modifiied:
- 2019-02-18
- Gene:
- AARSD1 NIH gene
- Name:
- alanyl-tRNA synthetase domain containing 1
- Previous symbol:
- -
- Synonyms:
- MGC2744
- Chromosome:
- 17q21.31
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-15
- Date modifiied:
- 2018-05-03
- Gene:
- ABCA2 NIH gene
- Name:
- ATP binding cassette subfamily A member 2
- Previous symbol:
- ABC2
- Synonyms:
- -
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-03-16
- Date modifiied:
- 2016-10-05
- Gene:
- ABCB1 NIH gene
- Name:
- ATP binding cassette subfamily B member 1
- Previous symbol:
- PGY1, MDR1, CLCS
- Synonyms:
- P-gp, CD243, GP170, ABC20
- Chromosome:
- 7q21.12
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2015-11-13
- Gene:
- ABCB10 NIH gene
- Name:
- ATP binding cassette subfamily B member 10
- Previous symbol:
- -
- Synonyms:
- EST20237, M-ABC2, MTABC2
- Chromosome:
- 1q42.13
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2016-10-05
Related products to: Polyclonal IRAK2 (C2)
Related articles to: Polyclonal IRAK2 (C2)
- : Chronic myeloid leukemia (CML), essential thrombocythemia (ET), primary myelofibrosis (PMF), and polycythemia vera (PV) are myeloproliferative neoplasms (MPNs) that require precise molecular characterization. Although driver mutations such as BCR-ABL1 and JAK2 are diagnostically important, they do not fully explain disease heterogeneity. The NanoString nCounter system enables direct multiplex gene expression analysis without RNA amplification and is suitable for degraded bone marrow specimens. This study aimed to analyze cytokine gene expression in bone marrow mononuclear cells of patients with MPNs and controls using NanoString technology, identify differentially expressed genes (DEGs) among MPN subtypes, and investigate their biological significance. : Bone marrow aspirates were collected from 19 patients with MPNs (CML, ET, PMF, and PV) and 6 control patients. Mononuclear cells were isolated, and RNA expression of a 40-gene cytokine panel was analyzed using the NanoString nCounter system with strict quality control and normalization. DEGs were identified for each MPN subtype, followed by Gene Ontology(GO) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analyses. : CML and PV demonstrated 20 and 12 DEGs, respectively. In contrast, ET showed only one DEG (IRAK2), and PMF showed none. Functional analyses revealed enrichment of cytokine signaling, Toll-like receptor (TLR), and JAK-STAT pathways in CML, indicating immune and inflammatory dysregulation. PV DEGs were associated with TLR signaling, IL-17 pathways, and cytokine-cytokine receptor interactions, suggesting active cytokine-mediated inflammation. CML and PV exhibited distinct cytokine-driven transcriptional signatures, whereas ET and PMF exhibited minimal alterations. These findings support the clinical utility of NanoString technology for bone marrow specimens and highlight disease-specific immune pathways as potential diagnostic biomarkers in MPNs. - Source: PubMed
Publication date: 2026/06/03
Bae Jun-HyungBae Kyung-JinCho Chi-Hyun - Interleukin-1 receptor-associated kinase 2 (IRAK2) is essential for the Myddosome complex formation downstream of Toll-like receptors. We identify twelve patients with a homozygous loss-of-function copy number variant in IRAK2, designated IRAK2-∆ex2. Most patients present with recurrent infections, autoantibody production, and gastrointestinal ulceration. Two patients were clinically diagnosed with primary immunodeficiency, while the majority fulfill diagnostic criteria for autoimmune or autoinflammatory diseases. The IRAK2-∆ex2 protein fails to interact with IRAK4, leading to impaired activation of nuclear factor kappa B signaling via the Myddosome complex. An elevated type I interferon signature is observed in the patients, which is confirmed in bone marrow-derived macrophages from knock-in mice and knockout cell lines. Mechanistically, our data are consistent with engagement of a TRIF-dependent interferon pathway. Baricitinib attenuates the elevated interferon signature in patient-derived cells ex vivo and cell lines. Here, we show IRAK2 deficiency as a monogenic immune dysregulation disorder. - Source: PubMed
Publication date: 2026/05/21
Fei YudieLiu LinMa ShuangyueJin YingWang ShihaoZhang LiangYang JunLiu YiLu MeipingXue JingLi JingyiChen XiangWang JunYao YuhaoLiu ChenluZhang JiahuiHan XuFu JinjianKang ZhijuanWang YushaSun XiangweiZhang ChangmingHe TingyanLiu ZhihuiGuo LiChen ChengshunZhao HongmeiGao XingjianZhong HuaWen LihongYu XiaominLiu ZhihongZhou Qing - (), a spiral Gram-negative bacterium colonizing gastric mucosa, damages epithelial cells, driving chronic gastritis, peptic ulcers, and gastric cancer. Mechanisms of its malignant transformation remain unclear. - Source: PubMed
Publication date: 2026/02/13
Zhang MinglinHe XueZhao XuelinCai TingLiu XiaomingWang Fen - This study explores repetitive Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) sequences from the archaea and (), as well as from the bacterium (). These sequences are compared with human microRNA (miRNA) sequences to investigate potential genetic similarities and disease associations. - Source: PubMed
Ramezani ReyhaneBehbahani MandanaMohabatkar HassanSarraf Mamouri KimiaHejazi Fatemeh - Titanium and its alloys are widely used in dental implants owing to their excellent biocompatibility and corrosion resistance, despite their elastic moduli mismatch with bone and insufficient interfacial bioactivity which often restrict their osseointegration performance, particularly in the early stage after implantation. To address these limitations, a boronized Ti6Al4V/hydroxyapatite (HA) composite with improved structural and biological performance was developed. Scanning electron microscopy and atomic force microscopy confirmed a micro/nanostructured surface with increased roughness. RNA sequencing of osteoblasts cultured on the composite identified 683 upregulated and 838 downregulated genes relative to Ti6Al4V. Gene ontology enrichment revealed biological processes related to cell adhesion, extracellular matrix remodeling, and integrin-mediated signaling, whereas KEGG pathway analysis indicated activation of cell cycle, PI3K/Akt, and calcium signaling pathways. Gene set variation analysis further highlighted eight key upregulated genes-CYP1A1, CRLF2, HBEGF, IRAK2, DLL1, CYP1B1, BLOC1S5-TXNDC5, and TRIP13. Functional validation demonstrated that the TRIP13 expression correlated positively with osteogenic differentiation, in conjunction with activation of the PI3K/Akt signaling pathway. Collectively, these findings proved a TRIP13-associated transcriptional response linked to osteogenic regulation on the boronized Ti6Al4V/HA composite surface, offering a mechanistic insight into the design of bioactive titanium-based implants with improved osseointegration. - Source: PubMed
Publication date: 2026/01/17
Chen YihongChen XiaojieLiu BoyuXiong HengrongPeng ZhiweiPeng Qian