Ask about this productRelated genes to: 6G5 COMP
- Gene:
- COMP NIH gene
- Name:
- cartilage oligomeric matrix protein
- Previous symbol:
- PSACH, EDM1, EPD1
- Synonyms:
- MED, THBS5
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-24
- Date modifiied:
- 2016-10-05
Related products to: 6G5 COMP
(4S)_4_Cyclohexyl_[(4_phenylbutyl)phosp Fosinopril related comp(R)_glycolic acid, compound with (S)_1,2, (R)_glycolic acid, comp(R)_glycolic acid, compound with [S_(R,S (R)_glycolic acid, comp(RS)_9_Fluoro_2,3_dihydro_3_methyl_7_or Ofloxacin related comp(S)_glycolic acid, compound with (R)_1,2, (S)_glycolic acid, comp1H_benzotriazole, compound with morph 1H_benzotriazole, comp1_(4_(5_Cyclohexyl_1H_tetrazol_5_yl)butox Cilostazol related comp1_[(2_Chlorophenyl)(methylimino)methyl] Ketamine related comp2,4_diethylbenzenesulphonic acid, comp 2,4_diethylbenzenesulp2_(Diphenylmethyl)thioacetamide Modafinil related comp2_Aminoethanol, compound with bis[2_[2( 2_Aminoethanol, comp3,3_bis(4_hydroxyphenyl)phthalide, comp 3,3_bis(4_hydroxypheny3_(3,4,6_Tirhydroxyphenyl)_alanine Levodopa related comp4,_dimethylbenzenesulphonic acid, comp 4,_dimethylbenzenesulp4,_dimethylbenzenesulphonic acid, comp 4,_dimethylbenzenesulp Related articles to: 6G5 COMP
- The gastrointestinal tract (GIT) represents the functional link between food and energy for organisms. It also harbors the gut microbiome, protects against toxins, and eliminates waste, all of which mediate individual health and fitness. The form and function of the GIT can be dynamic, allowing organisms to respond to-and buffer against-rapid changes in their environment and energetic demands. However, knowledge of intraspecific trait variation (ITV) in the GIT is sparse among different taxa and traits (e.g., microstructural traits and physiology). Additionally, the actual mechanics of how these changes occur (e.g., cell proliferation, cellular redistribution) remain largely unknown. This systematic review summarizes the current state of knowledge on mammalian GIT ITV at multiple levels (macroscopic, microstructural, and physiological), speculates as to how global change drivers will affect ITV, and suggests new directions for future work. A comprehensive list of mammal species heretofore examined for GIT morphology and ITV from a total of 260 journal articles or book chapters identified 824 mammal species with quantitative GIT traits available (12% of all mammal species), but only 79 species (1.1%) investigated for GIT ITV. This highlights the increased need to preserve and collect trait data in standardized ways for mammalian GITs, a series of organs typically discarded or unused during specimen preparation. Understanding how wild species utilize GIT ITV to cope with energetic costs will be crucial to predicting how species may fare under rapidly changing environments. - Source: PubMed
Publication date: 2026/06/08
Chapman Olivia - In this work, we describe the development and application of a low-cost fluid interface visualizer referred to as the "Meniscope." The device works using a color-based surface gradient detector method that maps the gradient of an air-water interface to a specific color on a target pattern below using a converging lens. Sample experiments are outlined that showcase the working principle and functional versatility of the device, with direct connections made to related biological phenomena. The device and assembly instructions were piloted in a hands-on workshop, with pertinent feedback reviewed herein. The Meniscope is a low-cost device that is capable of producing striking visualizations of static and dynamic free-surface deformations while introducing users to free-surface measurement techniques in an accessible and hands-on manner. - Source: PubMed
Publication date: 2026/06/08
Harris Daniel M - Since the first publication in 2014 reporting that progesterone is detectable in whale baleen, numerous studies have confirmed that patterns of hormones in baleen can provide a multi-year time series of continuous endocrine information from individual whales. The field is poised to expand substantially in the near future, and thus it is an opportune time to review findings and identify current knowledge gaps and pathways for future research. A search of baleen-hormone literature reveals 30 publications that, in total, investigate eight steroid hormones and two thyroid hormones in baleen of ten species of mysticete whale, with the pygmy right whale representing the only mysticete family not yet studied. An early phase of methodological validations optimized the technique, including reduction of sample mass requirement and improvements in hormone yield. Steroid hormones have consistently passed technical and physiological validations; thyroid hormones, however, are still in need of physiological validations. Later literature has entailed a series of descriptive studies, which typically combine endocrine and isotope analyses to elucidate typical hormone ranges and patterns across years in relation to species, sex, age class, and reproductive state. Most descriptive studies have been limited to a small n of individuals (a consequence of the high n of subsamples per whale), yet have been highly informative nonetheless, revealing many unexpected findings (e.g., evidence suggestive of extended gestation, timing and location of breeding, reproductive senescence, early sexual maturity, pregnancy loss, and effects of stressors). Such case-study reports remain of considerable value, but the field is increasingly expanding to include hypothesis-driven research on ecological questions of broad significance, such as influences of oceanographic factors and anthropogenic stressors, and the physiological and behavioral plasticity of individual responses to such environmental drivers. Addressing such questions will require robust statistical frameworks and larger sample sizes of individual whales, a daunting task given that a single baleen specimen can generate > 150 samples requiring months of labor and associated costs. Thus, increased collaborations could be both fruitful and necessary (e.g., a baleen-hormone research consortium wherein datasets can be pooled across research teams). In sum, baleen hormone research has provided unique and invaluable insights into patterns of physiology across time in the great whales and has great promise to continue advancing understanding of the biology of these vulnerable, long-lived, enigmatic species. - Source: PubMed
Publication date: 2026/06/08
Hunt Kathleen EJelincic JenniferLysiak NadineStimmelmayr RaphaelaCase AllisonEvey RebeccaAjó Alejandro FernándezDillon DanielleReed JoshuaNew LeslieBuck C Loren - Osteoarthritis (OA) represents a significant unmet clinical need, where current management strategies primarily alleviate symptoms but fail to halt disease progression and are often associated with adverse effects. Curcumin, a natural polyphenol, has emerged as a promising therapeutic candidate. To systematically evaluate its efficacy and mechanisms, we conducted a systematic review and meta-analysis of studies from databases including PubMed, Web of Science, CNKI, and Wanfang up to October 2025. Nineteen preclinical studies meeting the inclusion criteria were analyzed. The results demonstrated that curcumin significantly improved OARSI scores (MD = - 3.36), knee diameter (SMD = - 4.40), paw withdrawal threshold (MD = 4.36), and reduced apoptotic chondrocytes (SMD = - 9.50). Mechanistically, it enhanced antioxidant defense via SOD activity (SMD = 5.17) and suppressed the TLR4/NF-κB pathway, reducing key upstream signaling mediators (TLR4: SMD = - 1.41; NF-κB: SMD = - 3.72) and downstream pro-inflammatory cytokines (TNF-α: SMD = - 3.37; IL-6: SMD = - 10.19). Furthermore, it preserved cartilage metabolism by increasing type II collagen (SMD = 2.00) and decreasing MMP-13 (SMD = - 3.51) and COMP (SMD = - 2.95). These findings indicate that curcumin exerts multi-target protective effects in OA by mitigating oxidative stress, suppressing the TLR4/NF-κB inflammatory pathway, and reducing cartilage degradation, providing a theoretical foundation for its clinical translation. Future research employing standardized methodologies will be crucial to fully elucidate the mechanistic basis of curcumin's action and optimize its therapeutic potential for clinical applications. - Source: PubMed
Publication date: 2026/06/08
Liu HaoYe ZixiangWu ChenjiaCai ChennuoFang HuilingWang Qinglai - The ovary is continuously exposed to circulating corticosteroids, yet their physiological roles in oocyte physiology remain unclear. This study investigated how mineralocorticoids and glucocorticoids regulate nuclear maturation in bovine cumulus-oocyte complexes (COCs). COCs collected from 2 to 5 mm small antral follicles were subjected to 21 h of in vitro maturation (IVM). Immunohistochemistry and RT-PCR showed that the mineralocorticoid receptor (MR) and 11β-hydroxysteroid dehydrogenase type 2 (HSD11B2) were predominantly expressed in oocytes, whereas the glucocorticoid receptor (GR) was restricted to cumulus cells, specialized granulosa cells that surround and nourish the oocyte. Aldosterone increased the metaphase II (MII) rate at 50 nM but reduced it at 500 nM, with both effects abolished by the MR antagonist eplerenone. Cortisol at pharmacological levels (10 μM) similarly decreased MII%, and this inhibition was also reversed by eplerenone. To assess the protective role of HSD11B2, COCs were exposed to the HSD11B2 inhibitor 11-ketoprogesterone (11-kp) with or without cortisol (1 μM). Neither treatment alone altered MII%, whereas the combination significantly reduced MII%. These findings demonstrate that bovine oocytes are direct targets of mineralocorticoids and that both aldosterone and cortisol modulate nuclear maturation through MR. Moreover, HSD11B2 functions as a key protective mechanism preventing nonspecific MR activation by cortisol under physiological conditions. - Source: PubMed
Publication date: 2026/06/06
Kunori RyohdaiKashima AmiSakuma ChiakiTani NaokiTetsuka Masafumi