Ask about this productRelated genes to: 8H7 COMP
- Gene:
- COMP NIH gene
- Name:
- cartilage oligomeric matrix protein
- Previous symbol:
- PSACH, EDM1, EPD1
- Synonyms:
- MED, THBS5
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-24
- Date modifiied:
- 2016-10-05
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(4S)_4_Cyclohexyl_[(4_phenylbutyl)phosp Fosinopril related comp(R)_glycolic acid, compound with (S)_1,2, (R)_glycolic acid, comp(R)_glycolic acid, compound with [S_(R,S (R)_glycolic acid, comp(RS)_9_Fluoro_2,3_dihydro_3_methyl_7_or Ofloxacin related comp(S)_glycolic acid, compound with (R)_1,2, (S)_glycolic acid, comp1H_benzotriazole, compound with morph 1H_benzotriazole, comp1_(4_(5_Cyclohexyl_1H_tetrazol_5_yl)butox Cilostazol related comp1_[(2_Chlorophenyl)(methylimino)methyl] Ketamine related comp2,4_diethylbenzenesulphonic acid, comp 2,4_diethylbenzenesulp2_(Diphenylmethyl)thioacetamide Modafinil related comp2_Aminoethanol, compound with bis[2_[2( 2_Aminoethanol, comp3,3_bis(4_hydroxyphenyl)phthalide, comp 3,3_bis(4_hydroxypheny3_(3,4,6_Tirhydroxyphenyl)_alanine Levodopa related comp4,_dimethylbenzenesulphonic acid, comp 4,_dimethylbenzenesulp4,_dimethylbenzenesulphonic acid, comp 4,_dimethylbenzenesulp Related articles to: 8H7 COMP
- In this update we review new evidence on the rising prevalence of prior authorization rejections, delays and denials affecting US patients seeking access to branded prescription medications. We also examine a comparative study of cost-effectiveness thresholds cited in the USA and in countries designated as comparators under the Most-Favored-Nations Executive Order. - Source: PubMed
Publication date: 2026/08/27
Ramagopalan Sreeram VPannelay Annie Jullien - Integrative and Comparative Biology (ICB) seeks to explain biological diversity through the integration of form, function, development, physiology, behavior, and ecology across organisms and environments. Yet the field's history of synthesis has largely excluded Indigenous sciences, not because they lack empirical rigor, predictive capacity, or explanatory power, but because colonial scientific institutions have narrowly defined what counts as legitimate knowledge. Indigenous sciences are longstanding, place-based systems of inquiry grounded in careful observation, experimentation, interspecies relationships, and sustained intergenerational monitoring. They are not complementary supplements to Western science, nor alternative ways of knowing awaiting validation. They are autonomous scientific traditions that have generated sophisticated understandings of ecological processes over millennia. This paper argues that the exclusion of Indigenous sciences from ICB reflects broader histories of colonial knowledge production and the co-development of biological science with ethnological frameworks that marginalized Indigenous intellectual traditions. Drawing on Indigenous and decolonial science studies scholarship alongside canonical histories of comparative biology, this paper examines Indigenous salmon and fire stewardship as living scientific systems that continue to generate ecological knowledge while confronting state-imposed management regimes. Rather than asking how Indigenous sciences might be incorporated into existing biological frameworks, this paper asks what ICB can learn from scientific traditions that have long practiced integration across species, ecosystems, and generations, and what a genuinely reciprocal dialogue between sovereign scientific systems would require. - Source: PubMed
Publication date: 2026/08/26
Hernandez JessicaVereen Keon - Biological puncture systems span microorganisms, plants, invertebrates, and vertebrates, yet all must solve a common mechanical problem: creating a localized fracture in a protective barrier while avoiding failure of the penetrating structure and minimizing damage to the target. Living systems therefore provide diverse natural solutions to the same fundamental mechanical challenges faced by microneedles, making them useful comparators for bioinspired puncture design. This review examines representative biological puncture systems-including bacterial secretion needles, jellyfish nematocysts, insect stylets, snake fangs, plant trichomes, and drilling gastropods-through a unified mechanics-based framework encompassing biological context, geometry, materials, insertion dynamics, and functional integration. The comparative synthesis identifies that the apparent biological diversity collapses into a recurring mechanical design space governed by four recurring requirements: stress concentration, structural stability, interface control, and reduction of target resistance. Across taxa, successful puncture is achieved through convergent strategies including high-aspect-ratio geometries, localized reinforcement, material-property gradients, dynamic insertion mechanisms, lubrication, and multi-component architectures. Building on a mechanical definition of pain in which nociceptor activation arises primarily from tissue deformation, displacement, and shear rather than barrier fracture itself, we identify bioinspired principles for painless microneedle design. By comparing how biological systems achieve barrier breach while controlling structural failure and target disturbance, the review identifies design principles that can be translated to microneedles. The analysis suggests that the fundamental objective of biological puncture systems is not to maximize insertion force or penetration depth, but to create the required barrier breach while minimizing the volume of mechanically disturbed tissue. Key design implications include maximizing stress concentration, minimizing pre-fracture indentation, maintaining insertion stability, reducing friction, and limiting penetration to the depth necessary for barrier traversal. These findings provide a unifying biomechanical framework for translating biological puncture strategies into next-generation microneedles for minimally invasive drug delivery and diagnostics. - Source: PubMed
Publication date: 2026/08/26
Gurera DevBhushan Bharat - Determining the effects of chemicals used in agricultural pest control on non-target organisms such as parasitoids is crucial for biological control programs. The pupal endoparasitoid wasp Pimpla turionellae (Hymenoptera: Ichneumonidae) is an important biological control agent that relies on natural hosts, such as the greater wax moth Galleria mellonella (Lepidoptera: Pyralidae), to complete its development. This study aimed to evaluate the in vivo and in silico impacts of the antifungal agent terbinafine (TRB) on the oxidative stress markers and detoxification enzymes of adult P. turionellae. Host G. mellonella larvae were reared on artificial diets containing varying concentrations of TRB (0.001%, 0.01%, 0.1%, and 1%) until they reached the pupal stage, after which they were exposed to parasitism by P. turionellae. The results showed that the highest TRB concentration caused a statistically significant increase in PCO content and a significant decrease in cytochrome P450 monooxygenase (CYP450) activity in adult parasitoids. Conversely, high TRB concentrations (0.1% and 1%) induced a significant increase in glutathione S-transferase (GST) activity. To support these findings, using a publicly available RNA-seq dataset, a de novo transcriptome assembly was performed to predict candidate P. turionellae CYP450 and GST structures for molecular docking. TRB displayed strong binding affinities toward both CYP450 (-8.19 kcal/mol) and GST (-7.75 kcal/mol). In conclusion, TRB exposure via the host affects the oxidative status and detoxification enzymes of P. turionellae. However, the overall in vivo and in silico findings have strengthened the possibility of TRB being a suitable candidate for use in pest control. - Source: PubMed
Publication date: 2026/08/26
Çelik CihatAlkan ÇağrıŞenses Kerem MertBüyükgüzel EnderBüyükgüzel Kemal - NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors that detect pathogen-associated and damage-associated molecular patterns and mediate innate immune signaling in vertebrates. However, the genomic repertoire, evolutionary diversification, and infection-associated expression of NLR genes remain poorly defined in non-model amphibians. In this study, 66 NLR genes were identified from the Chinese spiny frog (Quasipaa spinosa) genome and designated as QsNLR1-QsNLR66. These genes were unevenly distributed across chromosomes and were classified into three phylogenetic groups, with most members exhibiting conserved motif architectures. Gene duplication analysis indicated that dispersed duplication was the main contributor to QsNLR expansion. Synteny analysis detected five conserved orthologous gene pairs between Q. spinosa and Pelophylax nigromaculatus, suggesting partial conservation of NLR genomic organization between the two amphibians. K/K analysis showed that several duplicated gene pairs, including NLRC3-like/QsNLR36 and NLRC3-like/QsNLR50, exhibited K/K ratios greater than one, suggesting potential sequence divergence after duplication. Spleen RNA sequencing (RNA-seq) after Aeromonas hydrophila challenge revealed enrichment of immune-related Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Weighted gene co-expression network analysis linked several QsNLRs to infection-associated modules, among which QsNLR57 was co-expressed with CYBB, ADAM17, SPI1, and HK2. RT-qPCR using time-matched phosphate-buffered saline (PBS) controls showed distinct temporal patterns, with stronger induction of QsNLR29, QsNLR57, and QsNLR66 and weaker or delayed responses of QsNLR50 and QsNLR56. These results characterize the NLR repertoire of Q. spinosa and identify infection-associated QsNLR candidates for future studies of antibacterial immunity in amphibians. - Source: PubMed
Publication date: 2026/08/26
Wang ZhigangXiao BoMo XichengZhang Ning