Ask about this productRelated genes to: MEM-259 CD63
- Gene:
- CD63 NIH gene
- Name:
- CD63 molecule
- Previous symbol:
- MLA1
- Synonyms:
- ME491, TSPAN30
- Chromosome:
- 12q13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-07
- Date modifiied:
- 2016-01-15
Related products to: MEM-259 CD63
0.5ml Screw Cap Tubes Screw Cap Assembled, Sterile0.5ml ScrewCap Tubes,Sterile0.5ml ScrewCap Tubes,Sterile Not Self-Standing, Caps On0.5ml ScrewCap Tubes,Sterile Not Self-Standing, Caps On259
25mm GLS MEM FILT HLDR GE# 1960-00225mm GLS MEM HLDR 50mlRES GE# 1960-03225mm SS MEM HLDR 25ml RES GE# 1960-0523'-phosphoadenosine 5'-phosphosulfate transporter,Adenosine 3'-phospho 5'-phosphosulfate transporter 2,C6orf196,CGI-19,Homo sapiens,Human,PAPS transporter 2,PAPST2,SLC35B3,Solute carrier family 35 mem47mm GLS MEM FILT HLDR GE# 1960-00447mm SS MEM HLDR 300mlRES GE# 1960-05490mm GLS MEM FILT HLDR GE# 1960-009AAAS AntibodyAAAS Mouse Monoclonal AntibodyAAAS Mouse Monoclonal Antibody (M02), clone 5A1 Related articles to: MEM-259 CD63
- While the presence of extracellular vesicles (EVs) and their cargo miRNAs is well established in human, cow and goat milk, their presence in infant formulae (IFs) was less documented. Particles whose EV nature was subsequently confirmed (size, microscopy) were isolated from whole goat milk powder (WGMP), from two IFs based on goat milk and from two based on cow milk using size exclusion chromatography. The qPCR analyses of RNA extracted from these EVs show that they contain mRNAs specifying major milk proteins and mammary epithelial cell markers, demonstrating the mammary origin of EVs. The miRNA profile and proteome of EVs were determined by small-RNA sequencing and TimsTOF Pro LC-MS, respectively. We identified a total of 1142 and 1162 proteins in goat and cow milk derived IFs, respectively, including EV-specific markers (as CD9, CD63) and proteins involved in vesicular trafficking. More than 350 miRNAs were identified and revealed that the expected milk miRNAs were among the most abundant in IFs. Among the 20 most abundant miRNAs, 16 were found in all IFs and WGMP, and 12 are described as the most abundant in human milk. They were predicted to influence cell life, protein and nucleic acid processes, or may be linked to inflammation. Differential analysis of miRNomes showed the type of milk (goat vs cow with 80 differential miRNAs) had the greatest impact, followed by the whey protein:casein ratio. This study demonstrates that EVs are present in milk-based IFs, which are a source of miRNAs. Further studies on their potential biological relevance for infants are warranted. - Source: PubMed
Publication date: 2026/05/22
Leroux CKrupova ZReyre MBevilacqua CHenry CAdamski FGallier SMartin P - To investigate whether mesenchymal stem cell-derived exosomes (MSC‑Exo) regulate ferroptosis by modulating the JAK2/STAT3 signaling pathway to alleviate hypoxia/re-oxygenation (H/R)-induced oligodendrocyte injury. - Source: PubMed
Meng Yuan-CuiWang ChaoZhu Yan-Ping - Spinal cord injury (SCI) is a severe condition with high disability. We aimed to explore the role and mechanism of M2-EVs in SCI-induced inflammation in rats, providing novel treatment methods for SCI. Primary macrophages were differentiated into M2 macrophages. M2-EVs were extracted, followed by morphology detection and measurement of CD63, TSG101, and Calnexin. SCI rats were injected with M2-EVs, followed by assessment of hind limb motor ability, pathological changes, nerve cell morphology, and proinflammatory factor expression. LPS-stimulated spinal astrocytes were treated with M2-EVs. Cell viability, ROS levels, LDH and MDA contents, the expression of lncRNA FTX, FTX, KDM3A, and KLF3, the binding of FTX to KDM3A, and KDM3A enrichment and H3K9me2 on the KLF3 promoter were detected. Results exhibited that M2-EVs treatment increased BBB score, recovered the damaged spinal cord structure, reduced neuronal loss and proinflammatory factor expression. M2-EVs treatment increased cell viability and decreased inflammation. Mechanistically, M2-EVs delivered FTX into cells. FTX bound to KDM3A and inhibited KLF3 expression via blocking H3K9me2 demethylation. KDM3A and KLF3 overexpression partially reversed the inhibitory effect of M2-EVs on inflammation in SCI. In conclusion, M2-EVs suppress SCI inflammation by delivering FTX into cells and inhibiting the KDM3A/KLF3 axis. - Source: PubMed
Publication date: 2026/06/16
Li JunjieLiang ShuhanLuo JinxinRao Yaojian - Dialyzer-associated anaphylaxis is an uncommon but serious complication of hemodialysis. Although severe anaphylaxis is rare, milder hypersensitivity reactions are likely underrecognized and frequently misattributed to cardiopulmonary or volume-related causes. In clinical practice, the diagnosis is often inferred indirectly from symptom resolution after dialyzer substitution rather than confirmed by immunologic testing. Serum tryptase is widely used as a marker of mast cell activation in anaphylaxis; however, its diagnostic utility is limited in patients with chronic kidney disease (CKD), in whom baseline tryptase levels may be chronically elevated due to reduced renal clearance. A patient with advanced CKD developed acute anaphylaxis with respiratory failure and hypotension during the initial hemodialysis session using a polysulfone-based dialyzer, requiring endotracheal intubation. Reexposure during a subsequent session reproducibly elicited the same reaction, strongly implicating dialyzer-associated anaphylaxis. Given the limitations of serum tryptase and the indirect nature of membrane substitution alone, a membrane-specific immunologic evaluation was pursued. Basophil activation testing (BAT) demonstrated polysulfone-specific basophil activation with upregulation of CD63 and CD203c, confirming immediate hypersensitivity. To our knowledge, this represents the first reported case in Korea of dialyzer-associated anaphylaxis immunologically confirmed by BAT. Using this case as a framework, we review the clinical spectrum and immunologic mechanisms of dialyzer-associated hypersensitivity and highlight the complementary diagnostic role of BAT in enabling definitive diagnosis and safe continuation of hemodialysis. - Source: PubMed
Publication date: 2026/06/11
Jung Ji YongMoon Da-HyeKim HyunsookChang Jae HyunKim Ae JinChoi Un JeongYe Young-Min - Tumor-produced extracellular vesicles (EVs) are key players in cancer progression by transferring their bioactive cargo (nucleic acids, lipids, proteins) to target cells leading to increase their proliferation, migration and invasive properties. EVs are involved in virus-associated carcinogenesis. Cervical cancer is due to a persistent infection with a high-risk human papillomavirus (HPV) whose integration into the cellular genome causes the continuous and deregulated expression of viral oncoproteins E6/E7, responsible for the carcinogenesis process. This study aimed to isolate EVs of HPV-infected cells, to explore their viral material content, to determine whether viral cargo can impact the proliferative status of HPV-lacking recipient cells. - Source: PubMed
Publication date: 2026/06/16
Arslan SergenBarbaud AlexandreBernauer JasonAvoscan LaureTissot MarionPrétet Jean-LucGobbo JessicaGarrido CarmenLascombe IsabelleFauconnet Sylvie