Ask about this productRelated genes to: 484D1 COMP
- Gene:
- COMP NIH gene
- Name:
- cartilage oligomeric matrix protein
- Previous symbol:
- PSACH, EDM1, EPD1
- Synonyms:
- MED, THBS5
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-24
- Date modifiied:
- 2016-10-05
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(4S)_4_Cyclohexyl_[(4_phenylbutyl)phosp Fosinopril related comp(R)_glycolic acid, compound with (S)_1,2, (R)_glycolic acid, comp(R)_glycolic acid, compound with [S_(R,S (R)_glycolic acid, comp(RS)_9_Fluoro_2,3_dihydro_3_methyl_7_or Ofloxacin related comp(S)_glycolic acid, compound with (R)_1,2, (S)_glycolic acid, comp1H_benzotriazole, compound with morph 1H_benzotriazole, comp1_(4_(5_Cyclohexyl_1H_tetrazol_5_yl)butox Cilostazol related comp1_[(2_Chlorophenyl)(methylimino)methyl] Ketamine related comp2,4_diethylbenzenesulphonic acid, comp 2,4_diethylbenzenesulp2_(Diphenylmethyl)thioacetamide Modafinil related comp2_Aminoethanol, compound with bis[2_[2( 2_Aminoethanol, comp3,3_bis(4_hydroxyphenyl)phthalide, comp 3,3_bis(4_hydroxypheny3_(3,4,6_Tirhydroxyphenyl)_alanine Levodopa related comp4,_dimethylbenzenesulphonic acid, comp 4,_dimethylbenzenesulp4,_dimethylbenzenesulphonic acid, comp 4,_dimethylbenzenesulp Related articles to: 484D1 COMP
- Stress response entails a complex array of interactions between the neuroendocrine system and physiological and behavioral effects. When a sensory stimulus is perceived as stressful, the brain triggers a response controlled by two key neuroendocrine systems: the sympathetic pathways for the "fight or flight" response, and the hypothalamus-pituitary-adrenal (HPA) axis, for a long-term stress response. Growing evidence suggests that nucleobindin (Nucb)-derived peptides nesfatin-1 and nesfatin-1-like peptide (NLP), two anorexigens and metabolic regulators, are also involved in stress regulation. Nesfatin-1 stimulates corticotropin-releasing hormone (CRH) in the hypothalamus to induce stress and satiety. Nesfatin-1 and NLP activate the stress axis, stimulating adrenocorticotropic hormone (ACTH) synthesis and modulating cortisol synthesis. Nesfatin-1 elicits stress behavior, such as anxiety and depression. Nesfatin-1 and NLP regulate both stress and metabolism, suggesting their role in interlinking these processes. This review discusses the involvement of nesfatin-1 and NLP in stress-related pathways in vertebrates, their mechanism of action, as well as existing knowledge gaps that warrant further research. - Source: PubMed
Publication date: 2026/06/12
Sethi PaalkiNasri AtefehUnniappan Suraj - Aquaporins (AQPs) are transmembrane channel proteins essential for water homeostasis and cellular stress responses. In marine bivalves, their roles in cold tolerance remain poorly understood despite frequent winter mortality events in aquaculture. Here, we identified nine AQP genes in the genome of the economically important noble scallop Chlamys nobilis. Phylogenetic analysis revealed strong conservation with other bivalve AQPs, and structural features, including conserved NPA motifs and ar/R selectivity filters, support their canonical water/glycerol transport functions. Tissue-specific expression profiling showed predominant enrichment in osmoregulatory tissues (gills, intestine) and gonads. Under both chronic and acute low-temperature stress from 23 °C to 9 °C, most CnAQP genes exhibited transient upregulation followed by suppression. Notably, CnAQP4 displayed sustained upregulation, implicating it as a key mediator of long-term cold adaptation. Promoter analysis further revealed abundant cis-elements linked to growth and development as well as immune regulation. Our findings provide the first comprehensive characterization of the AQP family in C. nobilis, highlighting its critical role in maintaining cellular integrity during cold stress and offering molecular targets for selective breeding of cold-tolerant scallop strains. - Source: PubMed
Publication date: 2026/06/09
He QiqiYan BeiyuLiu YaotingLiu ShitongLi YifanHu HaixinZhang HongkuanZheng Huaiping - The Class II myosin light chain (myl) genes in Chinese perch (Siniperca chuatsi) have not yet been systematically characterised, and relationships with muscle fibre specification, development, and injury-associated remodelling remain unclear. In this study, fast and slow muscle fibres were initially distinguished using myofibrillar ATPase histochemistry. Subsequently, genome-wide mining identified 16 Class II myl genes, comprising eight essential and eight regulatory light-chain subunits. Their conserved-domain features, chromosomal distribution, phylogenetic relationships and expression profiles were analysed. Transcriptomic profiling showed that summed myl transcript abundance was higher in fast muscle than in slow muscle, accounting for 67.2% of the pooled myl transcript pool across the two muscle types (paired t-test, raw P = 0.036). mylpfa, myl1 and mylz3 were the major fast-muscle-associated genes, whereas myl10, myl2b and myl13 were preferentially expressed in slow muscle at the transcript level. These patterns support these genes as candidate fibre-type-associated expression markers. Developmental profiling identified stage-associated myl expression patterns, including a possible expression shift between mylpfb and mylpfa. In the descriptive injury-repair time course (d0-d7), FPKM profiles indicated that fast-muscle-associated genes (mylpfa, mylz3 and myl1) were lower at d1 and recovered by d3, whereas several slow-muscle-associated genes showed biphasic transcript-level increases. The slow-muscle-associated RLC gene mylpfb showed a delayed expression peak at d7. Notably, the embryonic isoform myl6l showed a modest increase from approximately 2 FPKM at d0 to 4-5 FPKM after injury, suggesting a possible injury-associated expression pattern that requires further validation. Together, these findings provide a genome-wide description of the Chinese perch myl gene family and identify candidate fibre-type-associated genes and descriptive injury-associated isoform expression patterns. - Source: PubMed
Publication date: 2026/06/09
Fang YuhaoZhang LinxuanPan YaxiongZhu XinLi HonghuiBao LingshengChu Wuying - Mammary papillae are integral components of the mammary gland; however, they are frequently overlooked in pathological descriptions of the canine mammary gland, and dedicated studies focusing on these structures are scarce. The aim of this retrospective study was to characterize the most common mammary, cutaneous and developmental lesions affecting mammary papillae in dogs. A total of 173 mammary papillae with gross lesions were submitted from three veterinary diagnostic pathology laboratories for histopathological evaluation. Of these, 159 had microscopic alterations, yielding 167 histopathological diagnoses. Mammary lesions accounted for 122 (73.1%) diagnoses, while 45 (26.9%) were of cutaneous origin. Most lesions were neoplastic and corresponded to tumour types commonly affecting the mammary gland and skin. Developmental anomalies were identified in four papillae (2.3%). Canine mammary papillae had a broad spectrum of lesions involving both cutaneous and mammary components, most of which were malignant. Routine histopathological assessment of these structures is essential for comprehensive mammary diagnostics in veterinary practice. Comparative studies with human nipple pathology may further advance understanding of mammary papilla morphology and disease in veterinary medicine. - Source: PubMed
Publication date: 2026/06/12
Cassali Geovanni DSouza Fernanda RDos Reys Marina PWerner JulianaNakagaki Karen Y R - Neurogenesis takes place in the subventricular zone (SVZ) and in the dentate gyrus (DG) of the hippocampus of many adult mammalian species. Recent findings indicate that calpain-2 could participate in neurogenesis regulation through the truncation of the transcription factor, Myeloid Ecotropic Viral Integration Site 2 (MEIS2). The present study aimed to test the effects of calpain-2 inhibition/deletion on MEIS2 levels and neurogenesis in adult mice. - Source: PubMed
Publication date: 2026/06/09
Baudry MichelReece TristanShahi RoxanaTa KatelynBi Xiaoning