Ask about this productRelated genes to: 484D1 COMP
- Gene:
- COMP NIH gene
- Name:
- cartilage oligomeric matrix protein
- Previous symbol:
- PSACH, EDM1, EPD1
- Synonyms:
- MED, THBS5
- Chromosome:
- 19p13.11
- Locus Type:
- gene with protein product
- Date approved:
- 1994-05-24
- Date modifiied:
- 2016-10-05
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(4S)_4_Cyclohexyl_[(4_phenylbutyl)phosp Fosinopril related comp(R)_glycolic acid, compound with (S)_1,2, (R)_glycolic acid, comp(R)_glycolic acid, compound with [S_(R,S (R)_glycolic acid, comp(RS)_9_Fluoro_2,3_dihydro_3_methyl_7_or Ofloxacin related comp(S)_glycolic acid, compound with (R)_1,2, (S)_glycolic acid, comp1H_benzotriazole, compound with morph 1H_benzotriazole, comp1_(4_(5_Cyclohexyl_1H_tetrazol_5_yl)butox Cilostazol related comp1_[(2_Chlorophenyl)(methylimino)methyl] Ketamine related comp2,4_diethylbenzenesulphonic acid, comp 2,4_diethylbenzenesulp2_(Diphenylmethyl)thioacetamide Modafinil related comp2_Aminoethanol, compound with bis[2_[2( 2_Aminoethanol, comp3,3_bis(4_hydroxyphenyl)phthalide, comp 3,3_bis(4_hydroxypheny3_(3,4,6_Tirhydroxyphenyl)_alanine Levodopa related comp4,_dimethylbenzenesulphonic acid, comp 4,_dimethylbenzenesulp4,_dimethylbenzenesulphonic acid, comp 4,_dimethylbenzenesulp Related articles to: 484D1 COMP
- This study examines Moral Reconation Therapy (MRT) as a mandated narrative intervention focusing on how women on probation and MRT facilitators make sense of its emphasis on responsibility, honesty, and trust. Drawing on interviews with eight women on probation and two MRT facilitators at a Women Reentry Project, we conduct a dialogical narrative analysis. This approach examines how multiple, sometimes competing, voices emerge within the clients' accounts and those of the facilitators. Women frequently draw on institutional narratives of responsibility to account for compliance and credibility, while disclosures of trauma and addiction tend to surface later or remain only partially articulated. Facilitator narratives complicate dominant critiques of MRT by revealing how responsibility discourse is both enforced through authority and softened through care, community ties, and trauma-informed awareness. Rather than treating narrative contradictions as evidence of dishonesty or resistance, this analysis interprets them as dialogical tensions produced within a correctional storytelling regime. By centering collective storytelling, narrative competence, and power, this study moves beyond recidivism as the sole metric of effectiveness and offers a more nuanced account of MRT's impacts as multiple, contested, and relationally produced. - Source: PubMed
Publication date: 2026/08/14
Lynn VanessaConyers Addrain - Chitooligosaccharides (COS) has shown promising potential in enhancing the immunoprotective effects of Apostichopus japonicus. However, its intracellular distribution in within the coelomocytes of this species remains unclear. In this study, using fluorescein isothiocyanate (FITC) labeled COS technology combined with fluorescence microscopy and a microplate detection system, the uptake kinetics and subcellular distribution of FITC-COS in five types of coelomocytes (amoebocytes, fusiform cells, lymphocytes, hyaline cells and spherulocytes) were analyzed. The results indicate that the cellular uptake of FITC-COS was time- and dose-dependent, and exhibits distinct distribution patterns across various cell types: diffuse distribution in spherulocyte, polar distribution in fusiform cell, and early perinuclear punctate aggregation in lymphocytes. In all cell types, FITC-COS does not enter the nucleus. This study reveals the dynamic distribution patterns of COS in the immune cells of Apostichopus japonicus, providing cytological evidence for elucidating its immune-enhancing mechanisms and theoretical support for the development of COS as an aquatic immunostimulant. However, this study did not conduct co-localization experiments of COS with specific organelles, and its exact intracellular target remains to be further verified. - Source: PubMed
Publication date: 2026/08/13
Wang RongyueLiu JuanZhao GengtongNie XiaoyuZhang HuidongLi XiaofanWang XiaohangLi Ruijun - Acetyl-CoA carboxylase (ACC) and fatty acid synthase (FASN) are rate-limiting enzymes in the fatty acid biosynthetic pathway, yet their evolutionary relationships, sequence features, and expression profiles remain poorly understood in crustaceans, particularly in the economically important Chinese mitten crab (Eriocheir sinensis). Here, we identified and systematically analyzed ACC and FASN genes in E. sinensis using comparative genomic analyses across 43 species. ACC was highly conserved as a single-copy gene in invertebrates, in contrast to the multiple paralogs observed in vertebrates. Similarly, FASN was generally maintained as a single-copy gene across most taxa but exhibited lineage-specific expansion in certain insect groups. Phylogenetic and structural analysis revealed strong conservation of both genes within crustaceans, supported by multiple conserved motifs and canonical functional domains. Expression profiling showed predominant expression in the hepatopancreas and midgut, suggesting their potential involvement in crustacean lipid metabolism. During the molting cycle, ACC and FASN exhibited higher expression levels during stages C and D, suggesting an increased capacity for fatty acid biosynthesis before molting. In addition, dietary lipid levels experiment revealed that ACC and FASN expression responded dynamically to dietary lipid availability, with increased expression at moderate lipid levels but reduced expression under excessive lipid supplementation, indicating a possible adaptive transcriptional response to lipid status. Collectively, this study provides insights into the evolutionary conservation and expression dynamics of ACC and FASN and improves our understanding of lipid metabolic adaptation in crustaceans. - Source: PubMed
Publication date: 2026/08/13
Wei MaoleiDuan CunyuGu AoLi ShangZheng XiruiChen AqinWu Xugan - With the development and increased accessibility of diagnostic methods in veterinary medicine, the possibilities for early detection of proliferative lesions in the canine large intestine have expanded over the past decade. Since in human medicine, topoisomerase II alpha (Topo IIα) is considered a prognostic and predictive marker in various tumours, including colorectal carcinoma, we aimed to verify the role of this enzyme in proliferative epithelial lesions of the canine large intestine. In this study, we examined and compared the expression of Topo IIα in normal rectal mucosa, hyperplastic polyps, adenomas, and adenocarcinomas of the large intestine in dogs. Each type of lesion included 20 cases, in which the expression of Topo IIα was evaluated using immunohistochemistry. The median percentage of Topo IIα positive cells was 29.4% (IQR 24.9-37.1) in polyps, 30.3% (IQR 24.6-34.1) in adenomas, 36% (IQR 26.2-42.0) in adenocarcinomas, and 7.8% (IQR 5.9-10.6) in normal intestinal mucosa. Statistical analysis using the Kruskal-Wallis test followed by Dunn's post hoc tests with Bonferroni correction revealed significantly higher Topo IIα expression in hyperplastic polyps (p = 0.013, r = 0.62), adenomas (p = 0.033, r = 0.57) and adenocarcinomas (p = 0.002, r = 0.73) compared with normal rectal mucosa, with large effect sizes. Our results may serve as a preliminary basis for the potential use of anthracyclines in the treatment of canine colorectal adenocarcinomas, as well as in multiple adenomas or polyps when surgical options are limited. This study presents new insights of Topo IIα expression in canine large intestine carcinogenesis and could provide a valuable foundation for further clinical research. - Source: PubMed
Publication date: 2026/08/12
Fiedorowicz JoannaPaździor-Czapula KatarzynaKołodziejski Paweł AntoniOtrocka-Domagała Iwona - Human mucosal melanoma (hMM) is a rare but highly aggressive malignancy with poor clinical outcomes and limited responsiveness to current immunotherapeutic strategies. Unlike cutaneous melanoma, hMM is characterized by an ultraviolet-independent pathogenesis, low tumour mutational burden, and pronounced molecular and immunological heterogeneity, which collectively inhibit effective translational modelling and therapeutic development. Naturally occurring canine oral melanoma (cOM) shares key biological features with hMM, including spontaneous tumour development in immunocompetent hosts, low mutational burden, extensive structural genomic alterations, and a highly immunosuppressive tumour microenvironment. These shared characteristics support the positioning of cOM as a relevant comparative oncology model for investigating the mechanisms underlying tumour aggressiveness, immune evasion, and therapeutic resistance in mucosal melanoma. In this review, we synthesize evidence suggesting that hMM and cOM are driven less by single dominant oncogenic mutations than by a complex convergence of pathway-level dysregulation arising from pervasive copy-number alterations, structural variants, and epigenetic plasticity. We further highlight the influence of these molecular features on immune visibility and immune suppression, as well as their contributions to the limited efficacy of single-agent targeted therapies and immune checkpoint blockade. Insights from canine immunotherapy studies provide preliminary translational support for combination-based therapeutic strategies and biomarker development. By integrating molecular, epigenetic, and immunological perspectives across species, this review supports the use of cOM as a comparative and translational platform for advancing therapeutic innovation in mucosal melanoma. - Source: PubMed
Publication date: 2026/08/12
Kuo Chien-ChunChiu Chun-LungChung Cheng-ShuLin Lee-ShuanChen Ya-Mei