CCL11 Pre-design Chimera RNAi
- Known as:
- CCL11 Pre-design Chimera RNAi
- Catalog number:
- H00006356-R01
- Product Quantity:
- 10 nmol
- Category:
- -
- Supplier:
- Abno
- Gene target:
- CCL11 Pre-design Chimera RNAi
Related genes to: CCL11 Pre-design Chimera RNAi
- Gene:
- CCL11 NIH gene
- Name:
- C-C motif chemokine ligand 11
- Previous symbol:
- SCYA11
- Synonyms:
- eotaxin, MGC22554
- Chromosome:
- 17q12
- Locus Type:
- gene with protein product
- Date approved:
- 1996-04-24
- Date modifiied:
- 2016-10-05
Related products to: CCL11 Pre-design Chimera RNAi
Related articles to: CCL11 Pre-design Chimera RNAi
- Lung disease associated with systemic juvenile idiopathic arthritis (SJIA-LD) remains poorly understood. Evaluation of bronchoalveolar lavage fluid (BALF) may better reflect disease pathogenesis. The objectives of our study were to measure levels of cytokines and chemokines in BALF and their associations with clinical features and treatment in patients with SJIA-LD. - Source: PubMed
Publication date: 2026/07/17
Romankevych IvannaSproles AlyssaDo ThuyAuld LexiSabit TaskinChhaing RichardBaker ElizabethKumar AshishTrapnell BruceCarey BrennaBrewington John JTowe ChristopherGrom AlexeiSchulert Grant - Infection by the Zika virus (ZIKV) results in a broad spectrum of disease ranging from mild to severe neurological complications. The clinical features of ZIKV human infection are similar in pregnant women compared with nonpregnant women, though symptomatic infection is more frequent during pregnancy. However, little is known about the profile of systemic immune mediators during ZIKV infection in pregnant women. To characterize immunological mediators in ZIKV infection during pregnancy, we measured the levels of circulating cytokines, chemokines, and growth factors by multiplex immunoassay in 32 pregnant women, categorized according to trimesters of pregnancy. ZIKV-infected pregnant women presented higher levels of the cytokines IL-1β, IL-6, TNF-α, IL-12, IFN-γ, IL-17, IL-1Ra, IL-4, IL-5, IL-9, and IL-10 than healthy women. Moreover, a set of pro-inflammatory biomarkers, including IL-1β, IL-6, TNF-α, IL-12, IFN-γ, CCL11, and G-CSF, showed significant increased levels in the gestational second trimester than in the first trimester, which remains elevated throughout the third trimester. In conclusion, our findings indicate that ZIKV human infection during pregnancy triggers a strong and broad systemic inflammatory response, and during the viral infection, their kinetics of the production varied according to the gestational age. - Source: PubMed
Publication date: 2026/02/05
Teixeira-Carvalho AndréaAntonelli Lis Ribeiro do VallePontes Gemilson SoaresPrado Roberta OliveiraFrias Bruna Stefânia Dinizde Carvalho Kétyllen Reis AndradeCampi-Azevedo Ana CarolinaCoelho-Dos-Reis Jordana Grazielado Nascimento Valdinete AlvesMonteiro Dana Cristina da Silvada Silva Marineide SouzaAbdalla Lígia FernandesSantos João Hugo AbdallaGomes Matheus de SouzaAmaral Laurence RodriguesAlpoim Patrícia NessrallaGodoi Lara CarvalhoDusse Luci M SNaveca Felipe GomesMartins-Filho Olindo Assis - Allergic airway inflammation involves complex neuro‑immune interactions, yet the role of α2A‑adrenergic receptors (α2AR, encoded by Adra2a) in Tfh development and type 2 immunity remains poorly defined. HDM‑induced asthma model was established in C57BL/6 mice. RNA‑sequencing, correlation analysis, flowcytometry, immunofluorescence, and pharmacological interventions were used. Il33 knockout mice and T‑cell‑specific Adra2a or Akt1 knockout mice were generated. GEO datasets were analyzed for Tfh cell signatures. We found that HDM challenge significantly upregulated Adra2a in lung and lymph nodes. Adra2a expression was strongly correlated with type 2 chemokines Ccl11, Il33, and Ccl17. In Il33KO mice, Adra2a was among the top downregulated genes, and Il33 deletion broadly suppressed type 2 inflammation genes. Catecholamine‑metabolizing enzymes showed differential correlations: Maoa positively correlated with Adra2a and asthma genes, whereas Maob and Ddc were negatively correlated. α2AR was highly expressed on Tfh cells, especially on GC‑Tfh cells. α2AR activation aggravated airway inflammation, increased Tfh and germinal center B cells, promoted type 2 cytokines and IgE, and AKT phosphorylation. Conversely, T‑cell‑specific Adra2a knockout or Akt1 knockout attenuated these effects. α2AR is a key regulator linking neuro‑immune crosstalk to type 2 airway inflammation. It promotes Tfh cell differentiation and allergic responses via AKT signaling. Targeting α2AR may represent a novel therapeutic strategy for asthma. - Source: PubMed
Publication date: 2026/07/13
Lan GeleiDu JuanChen JieXie ShitaoLai XiaoyunZhao YueLiu YahuiHuang ChunrongDu XueqingSun YidanShi GuochaoSu Xiao - Adenomyosis, a common gynecologic condition of the uterus, affects women with diverse symptoms including pain. Traditionally evaluated pathologically, advanced imaging modality has led to more diagnoses including asymptomatic women. This noninvasive diagnosis has raised questions about disease progression and symptom development. This study aimed to investigate the cellular and molecular patterns associated with adenomyosis and adenomyosis-related pain, focusing on inflammatory processes. We employed an integrative, retrospective bioinformatic design combining publicly available bulk RNA-sequencing data from adenomyotic and control endometrium and myometrium with single-cell RNA-sequencing data from adenomyosis patients stratified by the presence of pain. - Source: PubMed
Publication date: 2026/07/08
Kwon KanghyunKwon Ji YoungSheen KisungYu SanghyeonKim Ye-AhYoo Eun HeeLee KiwonKim Man S - Aging entails complex physiological changes, yet large-scale evidence among older Japanese individuals, especially those with comorbidities, remains limited. We analyzed serum and plasma samples from approximately 3800 Japanese aged 40 years and older to identify age-associated proteins and lipids, focusing on reproducibility and robustness. Chemokines CXCL9 and CCL11 and phosphatidylcholines PC 31:0 and PC 32:0 were positively associated with age across five cohorts, whereas lysophosphatidylcholines LPC-LA and LPC-AA showed negative associations. These molecular relationships were consistently reproduced across serum and plasma matrices and replicated in independent cohorts. Cross-platform consistency was confirmed between Olink Target 96 (relative NPX) and Target 48 (absolute quantification), with direct validation in Cohort 2. To our knowledge, this is the largest study to demonstrate reproducibility of age-associated molecular biomarkers in a comorbidity-enriched Japanese population. The principal contribution is technical─defining a set of robust, cross-platform, cross-matrix biomarkers of aging in older adults. Unlike previous Western studies which focused on younger or healthier populations, this work establishes reproducibility and generalizability in real-world aging. These validated biomarkers provide a valuable reference for clinical and translational research, including risk stratification and biological age assessment in comorbidity-enriched settings. - Source: PubMed
Publication date: 2026/07/03
Tokuoka Suzumi MHamano FumieKobayashi AyakoNatsume TohruSugiyama MasayaMatsuda KoichiOda Yoshiya